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DOI: 10.1055/sos-SD-204-00129

MacMillan, D. W. C.; Watson, A. J. B.Science of Synthesis: Asymmetric Organocatalysis, (20121313.

The iminium DielsAlder reaction is a highly accessible new method for the asymmetric catalytic synthesis of enantioenriched carbo- and heterocycles.[‌30‌,‌32‌] Perhaps the most notable aspect of this method is the remarkable tolerance to reaction conditions (e.g., air, water) and substrates (e.g., those with certain heteroatom functionality) that can otherwise limit the effectiveness of conventional Lewis acid catalysis. A variety of α,β-unsaturated substrates participate in this transformation, which is mediated by a growing collection of catalyst scaffolds, several of which are commercially available.

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