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DOI: 10.1055/sos-SD-204-00129

MacMillan, D. W. C.; Watson, A. J. B.Science of Synthesis: Asymmetric Organocatalysis, (20121326.

Seven-membered ring construction via [4+3] cycloaddition offers an attractive method for the preparation of medium-sized carbo- and heterocycles.[‌56‌] Asymmetric transformations are typically carried out in a stoichiometric fashion, under a variety of conditions, with a general catalytic approach yet to be realized.

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Meeee Meeeeeee Meeeeeeeee Meeeeeeeee Meeeeee Meeee (eeee/eee) ee (%) Meeee (%) Mee
Meee Meeee
8 MM8Me8 (8.88M), 88°M eeee eeee 88 88 [‌88‌]
8 MM8Me8 (8.88M), 88°M eeee eeee 88 88 [‌88‌]
8 MM8Me8 (8.88M), 88°M 8.8:8 88e 88 [‌88‌]
8 MeMM8, 88°M eeee eeee 88e 88 [‌88‌]

e Meeee (eeee/eeeee) 8:8.

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Meeeee 8 Meeeeeeeee eeee e Meeeeee Meeeeeeeee eee Meeeeeeeeeeee ee Meeeeeeeeeee Meeeee[‌88‌]

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(8M,8M)-8-Meeee-8,8-eeeeeeee-8,8,8,8-eeeeeeeeee-8,8-eeeeeeeeeeeeeee[e]eeeeeee (88):[‌88‌]

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