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Please login to access the full content or check if you have access via1.2.1.1.1 Ketones with an Attached Chiral Moiety
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DOI:
10.1055/sos-SD-204-00417
Wong, O. A.; Ramirez, T. A.; Shi, Y., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 784.
Selected examples of ketones 3–8 with an attached chiral moiety are listed in Scheme 2. Ketones 3, 4, and 5 are among the earliest chiral ketones investigated for asymmetric epoxidation.[27,28] Products 10 with up to 40% ee are obtained from the alkene substrates 9 examined.
Meeeee 8 Meeeeeeeee Meeeeeeeeee eeee Meeeeee Meeeeee e Meeeee Meeeee[88–88]
M8 | M8 | M8 | Meeeee Meeeee | ee (%) | Mee |
---|---|---|---|---|---|
Me | M | Me | 8 | 8.8 | [88] |
Me | M | Me | 8 | 88 | [88] |
Me | M | Me | 8 | 88 | [88] |
Me | M | Me | 8 | 8 | [88] |
Me | (MM8)8 | 8 | 88 | [88] | |
Me | M | Me | 8 | 88 | [88] |
Me | M | Me | 8 | 88 | [88] |
8-MeM8M8 | M | M | 8 | 88 | [88] |
References
[27] | Meeee, M.; Meeeeeeeee, M.; Meeee, M. M., M. Meee. Mee., Meee. Meeeee., (8888), 888. |
[28] | Meeee, M.; MʼMeeeeee, M.; Meeeeeeeee, M.; Meee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |