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1.2.1.1.7 Synthetic Applications of (3aR,4′S,7aR)-2,2,2′,2′-Tetramethyldihydrospiro[[1,3]dioxolo[4,5-c]pyran-6,4′-[1,3]dioxolan]-7(7aH)-one

DOI: 10.1055/sos-SD-204-00417

Wong, O. A.; Ramirez, T. A.; Shi, Y.Science of Synthesis: Asymmetric Organocatalysis, (20121808.

(3aR,4S,7aR)-2,2,2,2-Tetramethyldihydrospiro[[1,3]dioxolo[4,5-c]pyran-6,4-[1,3]dioxolan]-7(7aH)-one (39), a catalyst with a broad substrate scope, is readily available, and both enantiomers can be synthesized. In recent years it has become widely used in complex molecule synthesis and some applications of ketone 39 in organic synthesis are highlighted in this section.

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