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Hof, K.; Lippert, K. M.; Schreiner, P. R., Science of Synthesis: Asymmetric Organocatalysis, (2012) 2, 382.
In 2008, Zhang and co-workers reported the 1,3-dipolar cycloaddition of azomethine ylides with nitroalkenes catalyzed by a cinchona alkaloid thiourea derivative.[266] Moderate enantiomeric excesses of 46–65%, diastereomeric ratios from 85:15 to >99:1, and yields in the range 49–77% are obtained.
Meeee ee 8888, eee Meee eeeee eeeeeeeee e eeeeee eee eee eeeeeeeeeeeeeeee 8,8-eeeeeee eeeeeeeeeeeee ee eeeeeeee 888 ee eeeeeeeeeeee 888.[888] Mee eeeeeeee ee eeeeeeeee ee e eeeeeeeeeee-8,8-eeeeeee-eeeeeee eeeeeeee 888. Meee eeeeeeeeeeee eeeeeeee ee 88–88% eee eeeeeeee, eeeeee eee ee e eeeeee eeeeeeee eeee (88% ee). Mee eeeeee eee ee eee eeeee 88–88%. Meeee ee eee eeee eeeeeee eee eeeee ee Meeeee 88.
Meeeee 88 Meeeeeeeeeeeeeee 8,8-Meeeeee Meeeeeeeeeeee ee Meeeeeee ee Meeeeeeeeeee Meeeeeeee ee e Meeeeeeeeee-8,8-eeeeeee-Meeeeee Meeeeeee[888]
M8 | M8 | Meeee (%) | ee (%) | Mee |
---|---|---|---|---|
8-MeMM8M8 | Me | 88 | 88 | [888] |
Me | Me | 88 | 88 | [888] |
8-MeM8M8 | Me | 88 | 88 | [888] |
8-Mee | Me | 88 | 88 | [888] |
Me | Me | 88 | 88 | [888] |
8-MeM8M8 | Me | 88 | 88 | [888] |
Me | (MM8)8Me | 88 | 88 | [888] |
Meeeeeeeeeee Meeeeeeee
8-Meeee-8-eeeeeeeeeeeeeeeeeeee 888; Meeeeee Meeeeeeee:[888]
M eeeeeee ee eee eeeeeee 888 (8.8 eeee), eeeeeeee 888 (8.8 ee, 8.88 eeee, 88 eee%), eee 8-Å eeeeeeeee eeeeee (88 ee) eee eeeeeee ee eeeeeeeeeee e-MeMMe (8.8 eM) ee 8 °M. Mee eeeeeeeeeee 888 (8.88 eeee, 8.8 eeeee) ee e-MeMMe (8.8 eM) eee eeeee ee eee eeee eeeeeeeeeee. Meeee 8 e, eee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeee eee, MeMMe/eeeeeeeee eeeee 8:88). Mee eeeeeeeeeeee eeeeee eee eeeeeeeeee ee eeeeee MMMM eeeeeeee (Meeeeeeee MM ee MM ee Meeeeeeee MM ee MM, eeeeee/eMeMM, 8.8 eM · eee−8, λ = 888 ee).
References
[266] | Mee, M.-M.; Meeee, M.-M.; Meee, M.-M., Meeeeee, (8888), 888. |
[267] | Me, M.; Mee, M.-M.; Mee, M.; Meee, M.-M., Meeeeee, (8888), 8888. |