You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via2.2.4.15 Pictet–Spengler Reaction
Please login to access the full content or check if you have access via
DOI:
10.1055/sos-SD-205-00205
Hof, K.; Lippert, K. M.; Schreiner, P. R., Science of Synthesis: Asymmetric Organocatalysis, (2012) 2, 383.
In the presence of a protic or Lewis acid, the reaction of β-arylethylamines with carbonyl compounds leads to ring closure and thus to the formation of tetrahydroisoquinoline derivatives. This reaction was published by A. Pictet and T. Spengler in 1911 and is thus called the Pictet–Spengler reaction.[133]
Meeeee–Meeeeeee eeeeeeeee eeeeeeeee ee eeeeeeee eeeeeeeeeee eeee eeeeeeeeeeee eeeeeee ee eee eeeee eeeeeeeee ee (+)-eeeeeeeee ee eeeeeeeeeee ee eeeeeee eeeeeee[888] (eee eeeee) eee (+)-eeeeeeeee, eeee eeeeeeeee ee Meeeeeee eee ee-eeeeeee.[888]
References
| [133] | Müeee, M.; Meeeó, M., Meeeeeeee Meeeeeeeeeee ee Meeee Meeeeeeee ee Meeeeee Meeeeeeee: Meeeeeeeee eee Meeeeeee Meeeeeeee, Meeeeeee: Meeeeeeee, (8888). |
| [268] | Meeeee, M. M.; Meeeee, M. M.; Meeeeeee, M. M.; Meeeeeee, M. M., M. Me. Meee. Mee., (8888) 888, 88888. |
| [269] | Meeeeee, M. M.; Meeee, M. M.; Meeeeeee, M. M., Mee. Meee., (8888) 88, 888. |
Return to Top