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2.2.4.15 Pictet–Spengler Reaction

DOI: 10.1055/sos-SD-205-00205

Hof, K.; Lippert, K. M.; Schreiner, P. R.Science of Synthesis: Asymmetric Organocatalysis, (20122383.

In the presence of a protic or Lewis acid, the reaction of β-arylethylamines with carbonyl compounds leads to ring closure and thus to the formation of tetrahydroisoquinoline derivatives. This reaction was published by A. Pictet and T. Spengler in 1911 and is thus called the PictetSpengler reaction.[‌133‌]

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