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3.4.1.1 Metal-Complex-Mediated Conjugate Reduction

DOI: 10.1055/sos-SD-206-00122

Mase, N.Science of Synthesis: Water in Organic Synthesis, (20121155.

Enals, enones, and α,β-unsaturated esters 1 are chemoselectively reduced to the corresponding saturated carbonyl compounds 2 by an octacarbonyldicobalt(0)water system at reflux (Scheme 2).[‌8‌] More convenient and cost-effective reduction of enones and α,β-unsaturated esters 1 is accomplished using a magnesiumzinc(II) chloride system under aqueous conditions, in which exothermic reductions are completed within 1 hour (Scheme 2).[‌9‌]

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References