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3.4.2.4.3 Metal-Free Catalytic Addition of Carbonyl Compounds

DOI: 10.1055/sos-SD-206-00122

Mase, N.Science of Synthesis: Water in Organic Synthesis, (20121176.

Organocatalytic conjugate addition reaction of carbonyl compounds to various electron-deficient alkenes in the presence of variable amounts of water, from substoichiometric to a large excess, has seen recent advances. The main focus of this section is the application of this methodology to the synthesis of valuable compounds through organocatalytic enamine or iminium catalysis.[‌72‌]

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