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8.4 Conclusions and Outlook

DOI: 10.1055/sos-SD-206-00612

Kobayashi, S.Science of Synthesis: Water in Organic Synthesis, (20121865.

In the above three examples, the reactions only proceed in aqueous media or the optimal selectivities are observed only in aqueous media. In each case, water plays a key role in the reactivity and selectivity. On the other hand, the role of water is not yet clear. Looking back on more than 100 years of the history of organic chemistry, almost all investigations have been carried out in organic solvents. Now that unique reactivities and selectivities have been discovered in water/aqueous media, more extensive studies on organic reactions in water are necessary.

While many basic and advanced textbooks entitled Organic Chemistry are now published, these can now be read as Organic Chemistry in Organic Solvents. New textbooks entitled Organic Chemistry in Water will and should be established. This Science of Synthesis volume may be a milestone, and furthermore, future books will cover many enzymatic reactions and amino acid and carbohydrate chemistry, which may lead to a real understanding of organic reactions in water. The new world of organic chemistry is waiting.