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1.1.1.1.1 Traditional Cross-Coupling Reactions

DOI: 10.1055/sos-SD-207-00004

Guram, A. S.; Milne, J. E.; Tedrow, J. S.; Walker, S. D.Science of Synthesis: Cross Coupling and Heck-Type Reactions, (201319.

The use of arylboronic acids as coupling partners in metal-catalyzed C—C bond-forming processes has become a mainstay in organic synthesis. These ubiquitous reagents are used across a variety of fields including pharmaceutical, agrochemical, fine chemical, and materials research. In many cases, arylboronic acids are crystalline, air-stable solids that are commercially available (or can be readily prepared) and serve as superb aryl-transfer reagents in palladium-catalyzed Suzuki–Miyaura coupling processes. As a testament to the value of these and related reagents, the 2010 Nobel Prize for chemistry was awarded to Richard Heck, Ei-ichi Negishi, and Akira Suzuki for the development of palladium-catalyzed cross-coupling reactions for C—C bond formation.[‌1‌,‌2‌]

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