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1.4.1.1 Formation of Unsymmetrical Biaryls from Arylzinc Compounds

DOI: 10.1055/sos-SD-207-00423

Gosmini, C.; Corpet, M.Science of Synthesis: Cross Coupling and Heck-Type Reactions, (20131624.

Biaryl compounds play an important role in industrial chemistry and can be found in commercially attractive targets ranging from liquid crystals to pharmaceuticals. The ability of arylzinc species to accommodate functional groups both on the arylzinc compound (nucleophilic substrate) and on the aryl halide (electrophilic substrate) provides considerable flexibility in the process.

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