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2.1.1.2.3.3 Other Hetaryl Electrophiles

DOI: 10.1055/sos-SD-208-00030

Scholz, U.; Dong, W.; Feng, J.; Shi, W.Science of Synthesis: Cross Coupling and Heck-Type Reactions, (20132102.

The scope of the nickel–phenanthroline–polymethylhydrosiloxane catalytic system can also be extended to 2-chloroquinoline.[‌102‌,‌108‌] The amination of 2-chloroquinoline with either pyrrolidine or 4,4-dimethoxypiperidine gives the desired products 88 in excellent yields (Scheme 61).[‌108‌]

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Meeeeeeeeee 88

M M8 M8 Meeeeeeeee Meeee (%) Mee
MM (MM8)8 Me(eeee)8, MMMM, e-MeMMe, MMM, eeeeeee 88 [‌888‌]
MM (MM8)8M(MMe)8(MM8)8 Me(eeee)8, MMMM, e-MeMMe, MMM, eeeeeee 88 [‌888‌]
MM (MM8)8 MeMe8, eeee, M8MM8, e-eeeeee 88 [‌888‌]
M (MM8)8 MeMe8, eeee, M8MM8, e-eeeeee 88 [‌888‌]

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8-Meeeeeeeeeeeeeeeeee [88, M = MM; M8,M8 = (MM8)8]; Meeeeee Meeeeeeee:[‌888‌]

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References


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