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2.6.1 C—F Coupling Reactions with Electrophilic Fluorinating Reagents

DOI: 10.1055/sos-SD-208-00368

McMurtrey, K. B.; Sanford, M. S.Science of Synthesis: Cross Coupling and Heck-Type Reactions, (20132551.

Electrophilic fluorinating reagents (F+ reagents) are the most common fluorine sources used in transition-metal-catalyzed fluorination reactions. These reagents are believed to act as oxidants and to promote fluorination through reactive high-valent late transition metal intermediates [e.g., palladium(III), palladium(IV), silver(II), or silver(III) compounds]. Due to the scarcity of methods for efficient C—F bond formation, both stoichiometric and catalytic transformations mediated by transition metals have considerable synthetic utility. Thus, both are discussed in detail in the following sections.