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2.7.1.10 Arylation of Alkanesulfonamides

DOI: 10.1055/sos-SD-208-00380

Marsden, S. P.Science of Synthesis: Cross Coupling and Heck-Type Reactions, (20132615.

Sulfonamides are important substructures found in many commercial pharmaceuticals, and hence there is significant advantage in being able to effect arylation of alkanesulfonamides. The arylation of phenylmethanesulfonamides can be achieved using identical conditions to those used in the arylation of sulfones in Scheme 82 (Section 2.7.1.9), although the scope of this transformation is not clear as only two examples are reported (Scheme 84).[‌101‌]

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