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3.1.1.1.1.1.1.1 With Iodoarenes or Bromoarenes

DOI: 10.1055/sos-SD-209-00005

Andersson, C.-M.; Andersson, M.Science of Synthesis: Cross Coupling and Heck-Type Reactions, (201338.

In an early attempt to expand the breadth of applicability of palladium-catalyzed arylation reactions, methyl cinnamate derivatives were prepared using rather unreactive (electron-rich) aryl bromides,[‌3‌] and it was shown that the ligands on palladium, such as phosphines, have an important role in the reaction. By using suitable ligands, otherwise unreactive electron-rich arenes, such as bromophenols or bromoanilines, can be made to participate in the arylation reaction. The phosphines shown in Scheme 2 are still frequently used, even though more efficient ligands, such as trialkylphosphines or palladacycles, are available.

Meeeee 8 Meeeeee ee Meeeeeeeeeeeeee Meeeeee ee eee Meeeeeee ee 8-Meeeeeeeeee eeee Meeeee Meeeeeee ee Meeeeeeeeeeee[‌8‌]

Meeeeeeeeee 8

Meeeeeeee Meeee (M/Me) Meee (°M) Meee (e) Meeee (%) Mee
Me8M 8:8 88 8e 8 [‌8‌]
Me8M 8:8 88 88e 8 [‌8‌]
(8-Mee)8M 8:8 88 88 88 [‌8‌]
(8-Mee)8M 8:8 88 88 88 [‌8‌]
(8-Mee)8M 8:8e 888 8.8 88 [‌8‌]
(8-Mee)8M 8:8 888 88 88 [‌8‌]
eee-8-eeeeeeeeeeeeeeeee 8:8 888 88 8 [‌8‌]
(8-MeM8MM8M8)8M 8:8 88 88 8 [‌8‌]
(8-Me8MM8M8)8M 8:8 88 88 ~8 [‌8‌]
(8,8,8,8-Me8M8M)8M 8:8 88 88 88 [‌8‌]
(8,8,8,8-Me8M8M)8M 8:8 88 888 88 [‌8‌]
(8-MeM8M8)8M 8:8 88 88 88 [‌8‌]
(8-MeM8M8)8M 8:8 88 88 88 [‌8‌]
(8,8-eMe8M8M8)8M 8:8 88 88 88 [‌8‌]
(8,8-eMe8M8M8)8M 8:8 88 88 88 [‌8‌]
(8-Me-8-e-MeM8M8)8M 8:8 88 88 88 [‌8‌]
(8-Me-8-e-MeM8M8)8M 8:8 88 88 88 [‌8‌]
(8-Me-8-Me8MM8M8)8M 8:8 88 88 88 [‌8‌]
(8-Me-8-M8MM8M8)8M 8:8 88 88 88 [‌8‌]
(8-Me-8-M8MM8M8)8M 8:8 88 88 88 [‌8‌]
8,8-(MeM)8M8M8MMe8 8:8 88 8e 8 [‌8‌]
(MMMM8MM8)8M 8:8 88 8e eeeee [‌8‌]

e Me eeeeeeee ee eeeee eee eeeeeeee eeee eeeeee eeeeeeee eeeee.

e MeMe8{M(8-Mee)8}8 eee eeee eeeeeee ee Me(MMe)8; M/Me eeeee eeeeeeee eee eeeeeeeee ee eee eeeeeee.

Mee eeeeeeeeee eeeeeee ee eeeeeeeee eeeeeee eee eeeeeee eeeeeeeeeee ee eeeeeeeeee eeee eeeeeee eeeeee-eeeeeeeeeee eeeeeeeeeee (Meeeee 8). Meee eeee eeeee eeeeeee eeeeeeeeee, ee eee eeeeeeee ee eeeeeee ee e eeeeeeeee eeeeee, eee eeeeeeeeeeeee eeeeeeeeee (8- eee 8-eeeeeeeeee) eeee eeee eeeeee ee eee eeeeeeeee eeeeeeee ee eeeeeee eeeeeeee eeeee. Mee-8-eeeeeeeeeeeeee eee eeeeeee ee eee eeeeee ee eeeeee eee eee ee eeeeeeeeeee eeeeeeee eeeeeeeee eeeeeeeee eee ee ee eee eeeeee eeee eee eeee eeeeeee.

Meeeee 8 Meeeeee Meeeeeeeeeeeeeeee eee Meeeeeeee ee Meeeee Meeeeeee eeee Meeeeee Meeeeeee-Meee Meeeeeeeeee[‌8‌]

Meeeeeeeeee 8

Me8 Meeeeeeee Meeee (M/Me) Meee (e) Meeee (%) Mee
8-MMM8M8 Me8M 8:8 88 8 [‌8‌]
8-MMM8M8 (8-Mee)8M 8:8 88 88 [‌8‌]
8-MMM8M8 Me8M 8:8 88 8 [‌8‌]
8-MMM8M8 Me8M 8:8 8 88 [‌8‌]
8-MMM8M8 (8-Mee)8M 8:8 8 8 [‌8‌]
8-MMM8M8 (8-Mee)8M 8:8 8 8 [‌8‌]
8-MeMM8M8 (8-Mee)8M 8:8 88 88 [‌8‌]
8-MeMM8M8 (8-Mee)8M 8:8 88 88e [‌8‌]
8,8-(MeM)8M8M8 (8-Mee)8M 8:8 8 88 [‌8‌]
8,8-(MeM)8M8M8 (8,8-eMe8M8M8)8M 8:8 88 88 [‌8‌]
8,8-(MeM)8M8M8 Me8M 8:8 88 8 [‌8‌]
8,8-(MeM)8M8M8 (8-Mee)8M 8:8 8 88 [‌8‌]
8,8-(MeM)8M8M8 (8-Mee)8M 8:8 88 8 [‌8‌]
8,8-(MeM)8M8M8 (8-Mee)8M 8:8 88 88 [‌8‌]

e Meee 8 eee% Me(MMe)8.

Mee Meee eeeeeeee eeeee e eeeee eeeeeeeee ee eeeeeee eeeeeeeeee eeeeee eeee eeeeeeeeee eeeee eeee eeeeeeeee ee eeeee ee eeeeeeee eeeee eeeeeeeee.[‌8‌] Mee eeeeeeee eeeee ee Meeee 8 eeeeeeeeeee eee eeee eeeee ee eee eeeeeee eeeeeeeee eeeeeee. Meeeee eee eeeee eeeee ee eee eeeeeeeeeee ee eeeeeeeee-eeeeeeeee eeeeeeeee eeeeeeeee, eee eeee (eeeeeeeeeeeee ee eeeeeeeeeeeee) eeee eeeeee ee eee eeeeeee. Meeeeeee eeee eeeeeeee ee eeeee eeeeee, ee ee eee eeee eeeeee ee eee e eeeee eeeeeee eeeeeee eeee ee eeeeeeeeeeeeeeeee ee eeeeeeeeeeee. Meeeeee eeeeee 8-eeeeeeeeeeeee eeeeee eeeeeeee, 8-eeeeeeeeeeee eeee eeeee ee eeeeeeeee eeeeeee, eeeeeeee ee e eeeeee ee eee eeeeee eeeeeeeee eeeeee ee eee eeee eeeeee; eeee eee eeee eeeeeeeeeeee ee eeeeeee eeeeeee. Meee, eeeeeee, eeee eeeeeeeeeeee eee eeeeee eee eeeeeeeee eeeee eeeee eeeeeeeeeee ee M—M eeeeeeeeee/eeeeeeeee eeeeeeeee (eee Meeeeee 8.8.8.8.8). Meee eeeeeee ee eeeeeeeee eee eeeeeeeeee eeeee eeeeeeeeeeeee, Meee eeeeeeeee[‌8‌] eeee “eeeeeeeeeee eeeee eeeeee eeeeeeeeee eeeee, eeeeee eeeeee—eeeeee eeeeee eee eeeeee eeeee eee α,β-eeeeeeeeeee eeeeeeee eeeeeeeee eee eeeee ee eeeee eeeeeeee.”

Meeee 8 Meeeeeeee-Meeeeeeee Meeeeeeee ee Meeeeeeee eee Meeeeee Meeeeeeeee eeee Meeeeeeeeeeeee Meeee- ee Meeeeeeeee[‌8‌]

Meeee Me8 M M8 M8 M8 M8 Meeeeeeee (eee%) Me(MMe)8 (eee%) Meee (e) Meeeee (%) Mee
8 8-MM8MM8M8 Me MM8Me M M Me (8-Mee)8M (8) 8 8.8 88 [‌8‌]
8 8-MM8MM8M8 Me Me M M Me (8-Mee)8M (8) 8 8.8 88 [‌8‌]
8 8-MeM8MM8M8 Me MM8Me M M Me (8-Mee)8M (8) 8 8 88 [‌8‌]
8 Me Me MM8M M M Me (8-Mee)8M (8) 8 8.8 88 [‌8‌]
8 Me Me MM8Me M M Me (8-Mee)8M (8) 8 8.8 88 [‌8‌]
8 Me Me MM8M M M Me Me8M (8) 8.88 8e 88 [‌8‌]
8 Me Me MM8M M Me Me Me8M (8) 8.88 88e 88 [‌8‌]
8 Me Me MM8M Me M Me Me8M (8) 8 88e 88 [‌8‌]
8 Me Me MM8Me Me M Me (8-Mee)8M (8) 8 88 88e [‌8‌]
88 Me Me MM8Me Me M Me (8,8-eMe8M8M8)8M (8) 8 88 88e [‌8‌]
88 Me M MM8Me Me M Me eeee 8 88 88e [‌8‌]
88 8-MMMM8M8 Me MM8Me M M Me (8-Mee)8M (8) 8 88 88 [‌8‌]
88 8-MMM8M8 Me MM8Me M M Me (8-Mee)8M (8) 8 8 88 [‌8‌]
88 8-MeMM8M8 Me MM8Me M M Me (8-Mee)8M (8) 8 88 88 [‌8‌]
88 Me MM8Me M M Me (8-Mee)8M (8) 8 8.8 88 [‌8‌]
88 8,8-eMe8M8M8 Me MM8Me M M Me Me8M (8) 8 88 88 [‌8‌]
88 Me Me MMMM8 M M Me (8-Mee)8M (8) 8 8.8 88 [‌8‌]

e Meeeeeee eeeee.

e Me 888 °M.

e Me 888 °M.

e Meeeee 8-eeeeeeeeeeeeee eee eeeeee ee e eeeeeeeee (8–88% ee MMM).

Meeeeeeeeee ee eee eeeeeeeeeeee ee eee eeeeeee eeee eeeeeee, eeeee eeeeeeee ee eee eeeee eeee eeeeeee > eeee eeeeeeee > eeee eeeeeeeee, eee ee eeeeeeee ee eeeeeeeeeee eeeeee eeeeeeeeeeeeeee eeeeeeeeeeeeeeee, ee eeeeeeeeeee ee Meeeee 8.[‌8‌] Meee eeeeeeee eeeeeee ee eee eeee eeee, eeeeeee eeeeeeeeee eeeeeee eeeeeeeee eeeeeeee eeee eeeeee eeeeeeeee eeeee, eee eeeeeeeeeeeee eeeeeeeeeee eeeeeee eeee eeeeee eeeeeeeee, eee eeeeeee, eeeeeeeeeeeeeeee eeeeeeeee.

Meeeee 8 M Meeeeeeeeeeeee Meeeeeeeee Meeeeeeee ee e Meeee(eeee)eeeee[‌8‌]

Me eeeeeeeee ee eeee eeee ee eeeeeeeee eeeeeeeeee eeeeeeeee eeeeeeee ee eeeeeee eeeeeeee ee eeeeeee eeeeeeeeeeee, eeee ee 8-eeeeeeeeeeeeee-8(8M)-eee (Meeeee 8).[‌8‌] Meeeeeeee, ee eeeee eeeeee eeeeeeee ee eee eeeeeee eeeeeeeee, eeeeeee 8-eeeeeeeeeeee-8(8M)-eeee, eeee ee 8, eee ee eeeeeeee eeee eee eeeeeeeeeeeee eeeeee 8-(8-eeeeeeeee)eeeeeeeee eeeee eeeeeee eeeeee eeeeeeee eeeeeeeeee (Meeeee 8).[‌8‌]

Meeeee 8 Meeeeeeeeeeeeeee ee Meee Meeeeeeee ee Meeeeeeeee[‌8‌,‌8‌]

Meeeeee 8-eeeeeeeeeeee-8(8M)-eeee eee ee eeeeeeee ee eeeee ee e eeeeee Meee/Meeeeeee–Meeeeee eeeeeeee.[‌8‌] Me eeee eeeeeeee, eee eeeeeeee eeee ee eeeeeee eeee (8M)-8-(8-eeeeeeeeeee)eeeeeeeeee (8), eeeee, ee eeee, ee eeeeeeee ee eeeeeeeeeeeeee Meee eeeeeeeee ee eeeeeeeeee eeee 8-eeeee-8-eeeeeeeeeee. M eeeeee ee 8-eeeeeeeeeeee-8(8M)-eeee 8 eee ee eeeeeeee ee eeeeeeeeee eeeeeeeeeeeeeeeeee eeeeeeeee eee eeeeeeeeeeeeee M-eeeeeeeee ee e eee-eee eeeeeee (Meeeee 8). Meeeeeee ee eeeeeee eeee eeeeeeeee eeee eeeeeeeeeee eeee ee eeee eee eeeeeee eeeeeeeeeeee, eeeeeeee ee e eeeeee ee e eeee ee eeeeeeeeeeeeeeee. M eeeeee eeeeeeeeeee eee ee eeeeeeee eeeeeeeeee, eeee e eeeeee eeeeeee ee eeeeeeeeeeeeeeeeee eeeeeee eee eeeeeeeeeeeeeeeeee eeeeeee ee eee eeeeeee, ee eeeeeee eee eeee eeeeeeee. Meeeeeeeʼe eeeeeeee[‌8‌] {eee[μ-(eeeeeee-κMM′)]eee[8-(ee-8-eeeeeeeeeeeeee-κM)eeeeee]eeeeeeeeeee(MM)} ee eeee eee eee eeeeeeeeeeeeee eeeeeeeeeee ee 8-(8-eeeeeeeeeee)eeeeeeeeee.

Meeeee 8 Meeeeeeeeeeeee Meeeeeeee-Meeeeeeee Meeeeeeee ee 8-Meeeeeeeeeee-8(8M)-eeee[‌8‌]

Meeeeeeeeee 8

Me8 Meee (e) Meeeee (%) ee 8 eeee 8 Mee
8-MeMM8M8 88 88 [‌8‌]
8-MeMM8M8 88 88 [‌8‌]
88 88 [‌8‌]
8-MM8M8 88 88 [‌8‌]
8-MM8M8 88 88 [‌8‌]
8-M8MM8M8 88 88 [‌8‌]
8-MeM8MM8M8 88 88 [‌8‌]
8-MMMM8M8 88 88 [‌8‌]
88 88 [‌8‌]
8-MeM8M8 88 8 [‌8‌]
88 88 [‌8‌]
8-MeMMeM8M8 88 88 [‌8‌]
8-MeMMeM8M8 88 88 [‌8‌]
Me 88 88 [‌8‌]

e Meeeeeee eeeee.

Me eee eeeeeeeee ee eeeeee eeeeeeee eeee eeeeee 8-eeeeeeeeeeeee, eeeeeeeeeeeee ee eeeeeeee ee e eeeeeeeeeee eeee eeeeeeee.[‌88‌] Me eeeeeeeee eee eeeeeeee eeeeeeeeee, eeeeee eee eeeeee Meee eeeeeee ee eee eeeeeeeeeeeee eeeeeee eee ee eeeeeeee ee eeee eeeee eeeee eeeeeeeeeeeee ee eee eeeeee eeeeeee (Meeeee 8).

Meeeee 8 Meee Meeeeeeee ee Meeee 8-Meeeeeeeeeeeee[‌88‌]

Meeeeeeeeeeeee eeeeeeee eeeeeeeee eeeeeeeee eee ee eeee ee eeeeeee eeeee-eeeee eeeeeeeee ee eeeeee eeeeeeeeeeeeee eeeeeeeeeee, eeee ee eee eeeeeeeeeee eeeeeeeeee 8-[8-(8-{[(8-eeeeeeeeeeee)eeeeeeee]eeeee}eeeee)-8-(8-eeeeeeeeeeee)eeeeee]eeeeeeeee eeee (8) (Meeeee 8).[‌88‌] Mee eeeeeeeeee eeeeeeeeee ee eeee eee eeeee eeeeee ee eeeeeeee ee eeeeeeeeee eee eeee eeee eeeeeee eeeeeeeee eeeee eeeee eeeeeeeee-eeee eeeeeeeeee, eeeeeee eeeeeeee eeeeeee eeeeeee eee eeeeeeee ee e eeeeeeeee eeeeee, eeee ee e eeeeeeeee, ee eeeeeee eeeeeeeee eeeeeeee. Me eeee eeee, eeee 8.8% ee eee eeeeeeeee eeeeeeeeeeee ee eeeeee. Meeeeeeeeeeee, ee eeeeeeeeeeeee eeeeee, ee ee eeeeeeee ee eeeeeeee eee eeeeeee ee eee eeeeeee ee e eeeeeeeee, eeeeeeee ee eeeeeeeeeee ee eeeeeeeee eee eeee eeeeeeeeeee.[‌88‌]

Meeeee 8 Meeee-Meeee Meeeeeeeee Meee Meeeeeeee[‌88‌]

Meeeeeeeee ee eeeeeeeee eeee eeeeeeeeeeee eeeeeeeee 8-eeeeeeeeeeeeeeeeeeee eeeeeeeee eee ee eeeeeeeeeeee eeee e eee-eee eeeeee Meee–eee-Meeeeee eeeeeeee eee eeeeeeeeeeeee eeeeeeeee ee eeeeeee 8,8-eeeeeee-8,8-eeeeeeeeeeeeeee 8,8-eeeeeeee ee eeeeeeeeeeeeeee eeeeeeeee.[‌88‌] Meeeeeeeee eeeeeeeee ee eee eeeeeeeeee eeee ee eee ee eee eeeeeee eeeeeeeeee eeeeeeeeeeee eeeeeee MMMM88 eeeeeeee e eeeee eee eeeeeee eeeeeeeeeeeeeee ee eee eeeeeeee (Meeeee 8). Meeeeee eeeeee eee eeeee 88% eeeee eeeeeeeeeeee ee eeeeee eee eeeeeeeeeeeeee.

Meeeee 8 Mee-Mee Meeeeeeeeeeee Meeeeeee Meeeeeeee ee 8,8-Meeeeee-8,8-eeeeeeeeeeeeeee 8,8-Meeeeeee ee Meeeeeeeee Meee eee Meeeeee Meeeeeeee[‌88‌]

Meeeeeeeeee 8

M8 M8 M8 M8 Meeee (%) Mee
M eeeeeeeeeee (MM8)8M(MM8)8 88 [‌88‌]
M Me M 8-eeeeeee 88 [‌88‌]
M MMM (MM8)8 88 [‌88‌]

Mee eeeee ee eee Meee eeeeeeeee ee eee eeeee eeeeeeeee ee eeeeeee eeeeeee eeeeeeee ee eeeeeeeeeeee ee e eeeeeeeee ee eee eeeee-eeee eeeee eeeee eeeeeee ee eee eeeeeeeeee eeeeeeeeeeeeeeeeeee M (88) (Meeeee 88). Meeeeeeee ee eee eeeeeeeeee eeeeeeeeee 88 eeee eee eeeeeeeeeeeeee eeeeeeeee 88 eeeeeeeeeee eee eeeeee eeeeee ee eee eeeeeeee eeeeeeeeee eeee eee eeeeeeee eee eeeeeeeee.[‌88‌,‌88‌] Mee eeeeeeee eeeeeeee eeeeeeee ee eeee eeeee (88%), eeeeeee eee eeeeeeee ee eeeeeee eeeeeeeeeee eeeeeeeee eeeeeeeeee eeeeeeeeee eeeeee. Meee eeeeee eeeeeeeeee eeeeeeee eeeeee ee eee Meee eeeeeeeee ee e eeeeeee eeeeeee. Meee eeee eee eeeeeeeeeeeeee eeeeeeee eee eeeeeeeeeeee eeeeeeeeee eee eee Meee eeeeeeee.

Meeeee 88 Meeeeeeee ee eee Meeee-Meee Meeee Meeee Meee ee Meeeeeeeeeeeeeeeeee M ee e Meeeeeeee-Meeeeeeee Meeeeeeee[‌88‌,‌88‌]

Meeeeee eeeeeeeeeeee ee eee eee ee eee Meee eeeeeeee ee eee eeeeeeeeeee ee eeeeeee eeeeeeee eeeeeee eee eeeeeeeee ee eeeeeeeee eee eeeeeee eeeeeeeee ee eeeeeeee ee e eeeeeeeee-eeeeeeee eeeeeeeeeeeeee eeeeeeee eeeeeeee ee e Meee eeeeeeee ee e eee-eee eeeeeeeeeee ee eeeeeee eeeeeeeeeeeeee eeeeeeee eee eeeeeeeee eee ee eeeeeeeeee ee eeeeeeeeeeeeeeeee-8.[‌88‌] Me eeeeeee ee eeee e eeeeeeee ee eeeee ee Meeeee 88. Meeee eeeeeeeee-eeeeeeee eeeeeeeee, eeee ee eee Meeeeeeeeee eee Meeeee eeeeeeeee, eee ee eeee ee eee eeeee eeeeeeeeeeeeeeeee.

Meeeee 88 Meeeeee ee e Meeeeee Meeeeeeeeeeeee Meeeeeee eee Meee Meeeeeee eee eee Meeeeeeeeee ee e Meeeeee Meeeeeeeee[‌88‌]

M eeeeeee eeeeeee ee eee eeeeeeeeeee ee eee Meee eeeeeeee ee e eeee eeeeeee eeeeeee ee eeeeeeee ee eee eeeeeeee ee eeeeeeeeeee eeeeeeeee 8- eee 8-eeeeeeeeeeeeeee eeeeeeeeeee ee eeeeeeeeeeee eeeeeeeee eeeee eeee eeeeeeeee, eeeeeeee, ee eeeee eeeeeee ee eeee eee eeeeeeeeeeee eeeeeeeee eee eeeeeeeeee eeeeeee.[‌88‌] Meee eeee ee eeeeeeeeeeeeee ee eeee eeeeeeee ee eee eeee, eeeeeeeeeee eeeeeeeee, eeeeeeeeee eeeeee eeeeeee ee eee eeeeeeeeeeee eeeeeee. Me eeeeeee, eee eeeeeeeeee ee 88 eeee 88, ee eeeee ee Meeeee 88.[‌88‌]

Meeeee 88 Meee Meeeeeee ee ee Meeeeeeeeeeeeeee Meeeeeeeee[‌88‌]

M eeee eeeee ee eeeeee-eeeeee eeeeeeeee eeeeeee ee eeeeeeeee eee ee eeeeeeee ee 88–88% eeeee ee eee eeeeeeeeeeee ee eeeeeeeeee eeeeeeee eeeeeeeeeeeee, ee eeeeeeeeeee ee Meeeee 88.[‌88‌] Meeeeeeeee eee eeeeeee eee Meee eeeeeeeee, eee ee eeeeeeee eeeeeeee eeee ee eeeeeeeee eee ee eee eeeeeeee eeeeeeee ee eee eeeeeeee eeeeeee.

Meeeee 88 Meeeeeeee eeee e Meeeeeeeee Meeeeeee Meeeeeeeee[‌88‌]

Meeeeeeee ee eeee-eeeee eeeeeeee ee eee eee eeee ee eee eeeeeeeeeee ee ee eeeeeeee eeeeee ee eeeeeeeeee eeeeee eeeeeeeeeee,[‌88‌] ee eeeeeeeeeee ee Meeeee 88 eee eee eeeeeeeee ee 8-eeeeeeeeeeee 88. Meee eeeeeeee eeeeeeee eeeeeee eeeeeeee eee eee eeeeeeeee eeeeeeeeeee eeeeeeeeee ee eeeeeeeee eeeeeeee eeeeeeeee ee M—M eeeee ee eee eeeeeeee ee M—Me eeeee. Meee eeeeeeeee eeeeeeeee ee eeeeeeeeeeee eeeeee ee eeeeee eeeeeee ee eeee eeeeeeee eeeeeeee eeeeeeeeee (eeeeeeeee ee 88, Meeeee 88).[‌88‌] Mee eee ee eeeee ee eee eeeeeee ee e Meee-eeee eeeeeeee ee eeeeee eeeeeee.

Meeeee 88 Meeeeeeeeee ee eeee-Meeee (8M)-8-(8,8,8-Meeeeeeeeeeeeee)eeeeeeee eee (8M)-8-(8,8,8-Meeeeeeeeeeeeee)eeeeeee Meee[‌88‌,‌88‌]

Me eeeeeeeee-eeeee eeeee ee eeeee eeeee[‌88‌] eee ee eeee ee ee eeeeeeee ee eeeeeeeeeeee M eeeeeeeee, e.e. 88 (Meeeee 88).[‌88‌] Meeeeeee eeeeeeee ee eeee eeeeeeee eee eee eeeeeeeeee eeeeeeeeeeee ee eeeeeeeeeeee eeeeeeeee eeeeeeeeeeeee eeeeeeee eee eee eeeeeeeeeeeeeeee eeeeeeeeeeeee ee eee eee eeeeee eeeee.[‌88‌]

Meeeee 88 Meee Meeeeeeee eee Meeeeeeeeeeeeeee Meeeeeeeeeeee Me Meeee ee Meeeeeeeeeee M Meeeeeeee[‌88‌]

Mee eeeeeeeee ee eeeeeeeeee-8,88-eeeeeeeeeeeeeeeee, eeeeeeeeeee eeeeee ee eeeeeeeee M-eeeeeeeeee eeeeeee, eeeeeeeeee eeeeeee eeeeeee ee eee eee ee e eeeeee Meee eeeeeeeee.[‌88‌] Me ee eeeeeeeee, eeee eeeeeee eeeeeee eee eeeeeeee ee eeee ee eeeeeeee eeeeee eeeeeeeee ee eeeeee eeeeeeeeeeeee eee eeeeeeee ee eeeeeeee-eeeeeee eeeeee eeee eee eeeeeeeee eeee eee eeeeeeeee eeeeeeee ee eeeeeeeeeeeeeeee. Meeeeeee eeeeeee eee 8,88-eeeeeeee eeeeeeee eee eee 8,88-eee(eeeeeeeeeeeeeeeeeeeeeeeee) eeeee eee eeeeeeeeeeeee eeeeeeeee eeeeeeee, 8,88-eeeeeeeeeeeeeeeee (88) eee ee eeeeeee ee e eeeee eee ee eeeeeeeeeee eeeeeeee eeeeeee M-eeeeeeeeeeee ee e eeeeeeee eeeeeeee ee eeeeeeeee(MM) eeeeeee eee 8,8-eee(eeeeeeeeeeeeeeeee)eeeeeee. Me eeeeeee ee eeee eeeeeeee ee eeee eeeeeee eeeeeeee 88, eeeee eeeee eeeeeeeeee eeeeeeee ee eeee eeeeee, ee eeeeeeeee ee Meeeee 88.

Meeeee 88 Meeeeeeee ee ee Meeeeeeeee Meeeeeeeeeee ee e Meeeee Meee Meeeeeeee[‌88‌]

Meeeee (8-eeeeeeeeeee)eeeeeeee eee ee eeee ee e eeeeeee ee e eeeeee eeeeeee eeeeeeee ee eeeeeeeeeeeeeeeeee.[‌88‌] Mee eeeeeeeeeeee ee e eee(eeee-eeeeeeeeeeeeee)eeeee eeeee ee e eeeeeeee eeeeeeeeee eeeeeeeee eeee e eeeeeeeeee Meee eeeeeeeee eeeee eeeeeeee eeeeeeeeee eeeeeeee e eeee eeeee ee eee eeeeeeee eeeeeee ee M- eee M-eeeeeeee ee e eeeee ee 88:88. Meeeeeee eeee eeeeeeeee ee ee eeeeee eeeeeee, eee eeeeeeee eee eeeeeeeeeee eeeeee eeeeeeeeeeeee eee eeeeeee eeeeeeeee eeeeeeeeeeee.

M eeeeeee eeeeee eeeeeeee e eeeee- eee eeeeeeeeeeeeeee eeeeeee eeeeeeee ee eeeeeeee eeee eeeeeeeeeee,[‌88‌] ee eeeee eeee(eeeeeeee eeeeee) eee ee eeeeeeee ee e eeeeeee eeeeeeeee eeeeeee. Meee eeeeee ee eeeee eeeeeeee eee eeeeeeee, eee eee eeeeeeee eee ee eeeeeeee ee e eee-eee eeeeeeeeeee, ee eeeeeeeeeee ee Meeeee 88.

Meeeee 88 M Meeeeeee Meee Meeeeeeeee ee Meeeeeeee ee e Meeeeee-Meeeee Meeeeeee[‌88‌]

M eeeeeee eeeee ee eee-eeeeeee eeeee eeeee ee eeeeeeee ee Meee eeeeeeeee ee eeeee (eeeeeeeee)eeeeeeeee ee eeee eee eeeeeeeeeeeee eeeeeeeeeeee eeeee, eeeee eee eeee eeeeeeeeeeee, eeeeeee ee eee eeeeeeee ee e eeeeee eeeeeee eeeeeee. Me e eeeeeeeeeeeeee eeeeeee, eeee eeeeeeee ee eeee ee eeeeeee eee eeeeeeeee eeeeeeeeee eeeeeeee eeeeeeeeeeee eeee eeeee 88 (Meeeee 88), eeeee eeeeee ee eeeeeeee ee eee eeeeeeee Meeeeeeeee eeeeeeeeeeee.[‌88‌] Meee eeeeeeeee Meee eeeeeeeeeeeeee, eeeee eee ee eeeeeeeee ee e eeeee eeeee, eeeeeeee eeeeee 8-(eeeeeeeeeee)eeeeeeee (88) eee eee eeeeeeeee eeeee 88 (eeeeeeeeeee eeeeeee eeee ee ee eeeeeeeeeee eeeeeeeee eeeeee eeeee eeeeeee Meee eeeeeeeeee). Me ee eeeeeee eee eeee, eeee eeeeeeeeeee ee eeeeeeee. Meeeeeeeee eeeeeeeeeeeeeeee eeeeeeeeeeeee eeeeeeee ee eeeeeeeeee eeeee eee eeeeeee eeeee eeee 88 ee 88% eeeeeeeeeeee eeeeee. Meee eeee eeee eeeeeeeeeeeee-eeeee eeeeeeeeeee ee eeeeeeeee eeeee eeeeeeeeeeee eeeeeeeeee eee eee Meee eeeeeeee.

Meeeee 88 Meeee-Meeee Meeeeeeee ee 8,8-Meeeeeee-e-eeeeeeee eeeeeee e Meeeeeeee-Meeeeeeee Meeeeeeee ee Meeeee 8-(Meeeeeeeeee)eeeeeeee[‌88‌]

Meeeeeee eee Meee eeeeeeee ee eeee eeeeee eeee eeeeeeeeeeeeeee eeeeeeee eeeeeee, eeeeeeeeee eeee eeeeeee eeeeeee ee eeeeeeeeeeee eeee ee eeeeeee eeeeeeeeeeee. Meee ee eeeeeee eeeeeeeeeeeeeeee ee eeeee eeee eee eeeeeeeeeeeeeeeee ee eeeeee eeeeeeeeee eeee.[‌88‌] M eeeeeee eeeeeee ee eee eeeeeeeee eeeeeeeee ee ee eeeee 8-eeeeeeeeeeeeee ee eeeee ee Meeeee 88.[‌88‌] Meeeeeee e eeeeee ee eeeeeeeeeee eeeeee eee eeeeeeeee eeeeeeeee eeeeeee 88 eee ee eeeeeeee ee eeeeeeeeee eee eeeeeeee ee eee eeeeeee eeee, eeeeeeee ee eeeeeeee eee eeeeee eeeeeeee. Meeee ee ee eeeeeeee eeeee eeee eeeeeee ee eee eeee-eeeeeeeeeee, eeeeee eee eee eeeeeeee eeee ee eeeee ee eee eeeeeeee eeee eeeeeee eeeeeeeeeeee eeeeeeee eeee.

Meeeee 88 Meeeeeeee-Meeeeeeee Meeeeeeee ee Meeeeeeeeee eeee Meeee 8-Meeeeeeeeeeeee[‌88‌]

Meeeeeeeeee 88

Me8 Meee Meeeeeeeee (%) Meeee (88/88/88) Meeee (%) ee 88 + 88 Mee
8-MM8M8 MeMMe 88 8.8:8:8.8 88e [‌88‌]
8-MM8M8 Me8M 88 8.8:8:8.8 88e [‌88‌]
8-MM8M8 eMe8MMe 88 88:8:8.8 e [‌88‌]
8-MeM8M8 Me8M >88 88.8:8:8.8 88e [‌88‌]
8-MeMM8M8 Me8M 88 8.8:8:<8.8 88e [‌88‌]
8-M8MM8M8 Me8M 88 8.8:8:8.8 88e [‌88‌]
8-MeM8M8 Me8M >88 8.8:8:8.8 88e [‌88‌]

e Meeee eeeeeeeeeeee.

e Meeee eeeeee eeeeeeeeeeeeee.

e Meeee eee eeeeeeee.

Me eeeeeee eeeeeeeeeeee, eee eeeeeeeee ee eeeeeeee eeeeeeee ee eeeeeeee eeeeeeee ee ee eeee eeeeeee. Mee eeee eeeeeee ee eee eeeeeeeee ee eeeeeeeeeeeeeee.[‌88‌] Meeeeeee ee eeeeeeeeeeeee eeeeeeeee eeeeeee ee eee M- eee M-eeeeeee ee eeeeeeee ee eee eeeeeeeee eeee, eeeeeeeeee ee eee eeeeeee eeeeee ee ee eeeeeeeeeee ee eeeee eeeeeeeee. Me eeee eeeeeeee, eee eeeeeee eeeeee eee,eee,eee-8,8,8,8-eeeeeeee[(eeeeeeeeeeeeeeeee)eeeeee]eeeeeeeeeeee (Meeeeee) ee eeee eeeeeeeee eeee eeeee eeeeeeeeee eeee ee eeeeeeeeeeeeeeeeee.[‌88‌] Meee eeee eeeeeeeee ee eeeeeeee eeee eeeeee, eeee ee eeeeeeeeeeee, eeeeeeeeee eeeeeeee eeeeeeee ee eeeee- eee eeeeeeeeeeeee,[‌88‌] eeeeeee eeee eeeeeeeeee eeee ee 8-eeeeeeeeeeeeeee, eeeeeeeeee eeeeeee ee eee eeeeeeeeeeee eeeeeeeee ee eeeeee eeeeeeeee ee eee 8-eeeeeeee, eee eeeeee eeeeeee eee eeeee. Meee eeeeeeeeeee eee eeeeeee eeeeeeee eee ee eeee eeeeeeeeeeee ee eeee eeeeeeee, ee eeeeeeeeeee ee Meeeee 88.

Meeeee 88 Meeeeeeee ee Meeeee 8-Meeeeeeeeeeeeee[‌88‌]

M eeeeee ee 8-eeeeee M-eeeeeeee eeeeeeeee eee ee eeeeeeeeeee ee eeeee ee e eeeeeeeeeeeeee eeeeee Meee eeeeeeee–eeeeeeeeeeeee eeeeeee[‌88‌] ee e eeee ee eeeeee eeeeeee eeeeeeeee ee Meeee eee Meeee.[‌88‌] Me eeee eeeeeeee, 8-eeeeeeeeeee-8-eeeeeee eee eeeeeeee eeee eeeeeee 8-eeeeeeeeeee ee 8-eeeeeeeeee eeeeeeee ee eeee eeeeeeeeee eeee eee eeeeeeee eee eeeeeeeeee eeeeeeeeeeeee ee eeee. Meeeeee eeeeeeeeee eee eeee eeeeeeee eee 88 eee% ee eeeeeeeee(MM) eeeeeee, 8 eeeeeeeeeee ee eeeeee eeeeeeee eeeeeeeee, eee 8 eeeeeeeeee ee eeeeeeeeeeeeeeeeee eeeeeee ee eeeeeeeeeeeeeeeee (8.88 M) ee 88 °M eee 88 eeeee. Mee eeeeee eeeeeeeeee eee ee eeeeeeee eeeeeee eeeeeeeeee eeeeeeeee ee M-eeeeeeeeeeeeeeee eeee eeeeee eeeeeeeee. M eeeeeee eeeeeeee ee eeeee ee Meeeee 88.

Meeeee 88 Meeeeeeee ee e Meeeeeee Meeeeeee ee e Meeeee Meee Meeeeeee–Meeeeeeeeeeee Meeeeee[‌88‌]

Me e eeee eeeeeeeeeee eee eeeee eeeeeee eeeeeee eeee eeeee eeeee ee ee eeeeeee eeeeee (eeeee ee eeeeeee eeeeeeeeeeeeeeeee), eeeeeee eeeeeeee-eeeeeeeee eeeeeeeeee, eeee ee eeeeeeeeee, eeeeeeeeeeeeeeeeeee (eeeeeeeeee), ee eeeeeeeeee, eeeeeee eeeeeeeee ee eeee eeeeeeee ee M- eee M-eeeeeee.[‌88‌] Meeeeee, eeee eeeeeee eeeeeeeeee, eeee eeeeee ee eee eeeeeeee eeeeeeee eee eeeeeeee eeee eeeeeeeeee eeeeeeeeeeeee (M/M >8:8) eeee eee eeeeeeeee eee eeeeeeeee ee e eeeeeeee eeee ee 888 °M. Mee eeeeeeee ee eeee eeeeeeee eee eeeee ee Meeeee 88.

Meeeee 88 Meeeeeeee ee Meeeeeee Meeeeeeeeee eeeee Meeeeee Meeeeeeeee[‌88‌]

M eeeeeee eeeeeeeee ee eeee eeeeeeee ee eee eeeeee eeeeeeeee ee eeeeeeeee eee eeeeeee eeeeeeeeee. Me eeeeeeeeee eee eeeeeeeeee eee eeeee 8 eeeeeeeeeee ee eee eeeee eeeeeeeee, ee ee eeeeeeee ee eeeeee eeee eeeeee ee e eeeee ee 8,8-eeeeeeeeeeeeeee, ee eeeeeeeeeee ee Meeeee 88.[‌88‌] Mee eee ee eee eeeeeee eeee eeeeeeeeeeee(eeeeee)eeeee ee ee eeeeeeeee eeeeeee ee eee eeeeeeee, eeeeeee ee eeeeeeeee eeeeeee ee eeeeeeee eeee eeeeee eeeeeeeeeeeee ee eeeeeeeeeeeeeeee. Meeeeeeeeee eee ee eeeeeeeee eeeeeeeee eeeee eeeeeeeeeeeeeeeee ee eee eeeeeee.

Meeeee 88 Meeeee Meeeeeeee ee eeee-Meeee Meeeeeee ee Meeee ee eee Meeeeee[‌88‌]

M eeeeeeeeeee eee eeeeeeeeeee eeeeee eeee-ee-eeee eeeeeeeee ee eeeeeeeee eeeeee ee Meee eeeeeeeee eeeeeeeee eeeee-eeeeeeeeeee (e.e., 88), eeeeeeeee ee eee eeeee′ eeeeeee 88 ee eeeeeeee ee eee eeeee eeeeeee 88 (Meeeee 88).

Meeeee 88 8,8-Meeeeeeee Meeeeeeee ee Meee Meeeeeeee ee eeeee-Meeeeeeeeee[‌88‌]

Mee eeeee ee eeeee ee eeeee′ eeeeeeee ee eeee eeeeeeeee eee ee eeeeeeeeee ee eeeeeee eee eeeeeeeeee, ee eeeeeeeeeee ee eee eeeeeeee eeeee ee Meeee 8.[‌88‌]

Meeee 8 eeeee-ee-eeeee′ Meeeeeeee Meeeeeeee ee eee Meeeeeeee ee Meeee Meeeeeee eeee 8-Meee-8′-eeeeeeeeeeeeee[‌88‌]

Meeee Meeee Meeeeeee (Meeee) Meeeeeeeeee Meeeeee (eM) Meee (e) Meeeee (eeeee/eeeee′) Meeee (%) Mee
8 8 MMMMe, MeMMM8 MMM (8) 88 888:8 eeeee [‌88‌]
8 8 MMMMe, MeMMM8 MMM (8) 88 88:8 eeeee [‌88‌]
8 8 MMMMe, MeMMM8 MMM (8) 88 88:88 88 [‌88‌]
8 8 MMMMe, e-MeMM8Me MMM (8) 88 88:88 88 [‌88‌]
8 8 e-MeMM8Me MMM (8) 88 88:88 88 [‌88‌]
8 8 eeee (8 eee%), e-MeMM8Me MMM (8) 88 88:88 88 [‌88‌]
8 8 Me8M (88 eee%), e-MeMM8Me MMM (8) 88 88:88 88 [‌88‌]
8 8 eeee (8 eee%), MeMMe MMM (8) 88 88:88 88 [‌88‌]
8 8 eeee (8 eee%), MeMMe MMM (8) 88 88:88 88 [‌88‌]
88 8 eeee (8 eee%), e-MeMM8Me eeeeeee (8) 88 88:88 88 [‌88‌]
88 8 eeee (8 eee%), Me8M MMM (8) 88 888:8 88 [‌88‌]

e Meeeeee eeeeeeeeee: 8-eeee-8′-eeeeeeeeeeeeee (8.88 eeee), Me(MMe)8 (8.8888 eeee), eeee (8.8 eeee), MMMMe (eeeee eeeeeeeee; 8.88 eeee).

e Me MMM eeeeeeeeeeee.

Meeeeee eeeeeee eee eeee eeeeeeee ee (eeeeeeeeee)eeeeeeeee.[‌88‌] Meee eeeeeee eeeeeeee ee eeeee-ee-eeeee′ 8,8-eeeeeeeee eeeeeeeee eeee eee ee eeeeeeeee ee eeeeeeeeeee ee ee eeeeeeeeeee eeeeee ee eeeeeeeeee. Mee eeeeeeeeeeeee eee eee eeeeeeeeeeee eeeeeeee eeeeeeeee eeee eee eeeeeeeee MM eeeeeee. Meeeeee eeeeeee, eeee ee 8-(8-eeeeeeeeee)eeeee[e]eeeee ee 8-(8-eeeeeeeeee)-8-eeeeee-8M-eeeeee, eeee eeeeeee eeee eeeeeeeee eeeeeeee ee eeee eee eeeee′-eeeeeee eeeeeee eeeeee eeeeeeeeeee.[‌88‌] Meeee eeeeeeee, eeeee eeeeeeeeeee eeeee eeeeeee eeee ee eeeeeeeeeee eeeeee ee eee eeeeeeee eeeeeeee eeeee ee eeeeeeee eee eee Meee eeeeeeeee ee eeeeeee eeeeeee; eeee eeee eeeeeeeeeee eee eeeeeeeee ee eeeeeeeeee eeeee ee eeeeeeeee eeeeeeeee.

Meeeeeeeeeeeeeeee eee ee eeeeeeee ee eeeee eeeeeee-eeeeeeeee eeeeeeeee eeeeeeeee ee e eeeeeeeeee Meee eeeeeeeee eee Meeeeee eeeeeeee.[‌88‌] M eeeeeee ee eeeeeeeeeeeeeeeee eee ee eeeeeeee ee eeee eeeeeee eeeeee eeeee e eeeeeeee eeeeeeeeee ee eeeeeeeeeeeeee eeeee ee e Meeeeeeeee eeeee; ee eeeeeee ee eeee e eeeeeeee ee eeeee ee Meeeee 88. Mee eeeeeeee eee ee eeeeeeee ee eeeee 88 eeeee ee eeeeeeeeeee eeeeeeee eeeeeeeeee eee eeeeeeee (eeeeee eeeeeee eeeeee eeee e eeeeeeee eeeee eeee eee eeeeeeeeeeeeeeeee ee eee eeeeeee).

Meeeee 88 Meeeeeeeeeeeeeeee ee Meeeeeeeee Meee Meeeeeeee, Meeeeee Meeeeeeeeeeee, eee Meeeeeeeee[‌88‌]

Meee eeeeeee eee ee eeeeeeee ee eee eeeeeeeee ee (8-eeeeeeeee)eeeeee ee eeeeeeee eee eeeeeeeeeeee eeeeeeeeeee eeeeee eeeeeeeeee eee Meeeeee eeeeeeeeeeeee.[‌88‌] M eeeeeee ee eeeeeeeee eeeeeeeee eeeeeeeee eee eeeeeeeeee eee eeee eeeeeeee eee eeeeeeeeeeee eeeeeeeee.[‌88‌] Mee eee eee eeeeeee ee eeeeeeeee eeeeeeeee ee eeeeeeeeee eeeeeeeeeeeeee eeeeeeeee ee eeeeeeeee ee e eeeeee.[‌88‌]

Meeeeeeeeeee eeeeeeeee 88 (M8 = Me, Me, e-Me) ee 88 (M8 = Me, e-Me), eeeeeeeeee eeee eeeeeeeeee ee eeee eeeeee eeeee, eeeeeeeeeeee, eee eeeee eee eeee eeeeeeeee eeeeeeeee eee eee Meee eeeeeeee (Meeeee 88).[‌88‌‌88‌] Meeeeeeeeee eeee eee eeeeeeeee eeeeeeeeeee eee ee eeeeeeeeeeee eeeeeeeee eeee eee eeeeeeeeeeeee eeeee eeeeeeeeee ee e eeeeeeee eeeeeeeee ee eee eeeeeeeeeeeeeeeeeee 88 (M8 = Me) eeee eeee eeeeeeee eeeeeeee eeeeeee (Meeeee 88).[‌88‌]

Meeeee 88 Meeeeeeee ee Meeeeeeeeeee Meeeeeeee, eee Meeeeeeeeeeee ee Meeeeeeee Meeeeeeeee ee e Meeeeeeeeeeeeeeeeee ee eee Meeeeeeee ee Meeeeee Meee Meeeeeee eeee Meeee Meeeeeee[‌88‌,‌88‌]

Meeeeeeeeee 88

M [Me] (eee%) Meeee (°M) Meee (e) Meeeeeeeeee (%) Meeeee (%) MMMe Mee
Me 8.8888 888 88 88.8 88 888 888 [‌88‌]
Me 8.8888 888 888 88.8 88 888 888 [‌88‌]
Me 8.88888 888 88 88.8 88 8 888 888 [‌88‌]
Me 8.88888 888 888 88.8 88 8 888 888 [‌88‌]
Me 8.888888 888 88 88.8 8 8 888 888 [‌88‌]
MMM 8.88888 888 88 88.8 88 8 888 888 [‌88‌]
M 8.888 888 888 88.8 88 88 888 [‌88‌]
MMe 8.888 888 888 88.8 88 88 888 [‌88‌]
MMe8 8.88 888 88 88.8 88 8888 [‌88‌]
MM 8.88 888 88 88.8 88 8888 [‌88‌]
MM8 8.88 888 88 88.8 8 88 [‌88‌]
Me 8.88e 888 88 88.8 88 8888 [‌88‌]

e Meeeeee eeeeeeeeee: eeee eeeeeee (88 eeee), eeeeee (88–888 eeee), MeMMe (88 eeee), MMM (88 eM).

e Meeee ee eee eeee eeeeeee eeeeeeee, ee eeeeeeeeee ee MM/MM.

e Meeeeeeeee ee MM/MM.

e Meeeeeee eeeeee (eeeee eeeeeee/eeeee Me).

e Meeee eeeeeeee 88 (M8 = e-Me).

Mee eeeeee-eeeeeeeeee eeeeeeeeeeeee 88 (M8 = Me, e-Me), eeeeeeeee eeeeeee eeee eeeeeeee eeeeeeeeee (Meeeee 88), eee eeee eeeeee ee eeee eeeeeeeeeeee, eee, eee eeeee.[‌88‌] Meeee eeeeeeeee eeeeeee eeeeeeeee eeee eeeeeeeeee, eeeeeeeeeee, ee, eeeeeeeeeee, eeeeeee eeeeeeee-eeeeeeeee eeeeeeeeeeee. Meee eeeeeee eeeeeeeeee, eeeeeeee eeeeeee eeeeeeeee 8 888 888 eee eeeeeeeeee.

Meeeeee eeeeeeeeeee eeeeeee eee eeeee ee eeeeeeeeee eee eeeeeeeee eeeeeeeee. Me eeeeeee ee eeee e eeeeeeee ee eeeeeeeeeeeeeee eeeeeeeee eeeeeeee ee eeeeeeeee ee eeeeeeeee(MM)-eeeeeeeee eeeeeeee eeeee.[‌88‌] Mee eeeeeeee eeee eeeeeeeee ee eeeeeeee ee eeeeeeeeee eeeeeeee eeeee ee eeeee, eeeeeeeeee eeeeeeeeee eee eeeeeee eee 8 eeeeeee, eee eeeeeeee eeeeeeeee. Mee eeeeeeeee eeeeee ee eeeeee eee eeeee ee eeeee ee 88 °M. Meee eeeeeeee eeeeeeeeee e eeeeee ee eeeeeeeeeee eeeeeeeeeee eeee eee eeeeeeeeeeeee eeeee eeeeeeeeee eeee eeeeeeeee eeee eeeeeeeeeee (eeeeeeeee >88%) eee eeee eeeeee (88–88%). Me eeee eeee eeeeeeeeeeeee eeeeeee, eee eeeeeeeee eeeeeeee eeeeeee eeeeeeeee eeeeeee. Meeeeeeeeee, eee eeeeeeee eee ee eeeeeeeee eee eeeeeeee eeee eeee eeeee eeeeeeee ee eeeeeeeee. Meeeeeeeee eeeeeeeee Meeeee eeee eeeeeee eeeeeeeee eee eeee eeeeeeeee.[‌88‌]

Meeeeeee ee eeeeeeeeeeeeeee eeeeee (eeeee) eeeeeeeee eee eeeeeeeeee eee eeeee ee Meee eeeeeeeeee ee eeeeeee eeeeeeee. Me eee eeeeeee ee eeee e eeeeeeee, eee eeeeeeee-eeeeeee eeeeeeeee eeeeee eeeeeee 88 (Meeeee 88) eeeeeeeee eee eeeeeeeee ee eeeee ee eeee-eeeee eeeeeeee ee e eeeee eeeeeeeee.[‌88‌] Meeee eeeeeee eeeeeeeeee (eeeeeeeeeeeee eee eeeeeeeeeeeeeeeeee eeeeee ee 888 °M), eee eeeeeeeeeee eeeeeeeeeee eeeeeeeee eeeeeee 88 eeeee eeeeee eeeeee ee eeeeeeee eeee e eeeeeeeeee eeeeeeeee ee eeeeeeeeee.

Meeeee 88 Meeeeeeee ee eeee-Meeee Meeeeeee ee Meeee Meeeeeeeee e Meeeeeee-Meeeeee Meeeeeeee Meeeee Meeeeee[‌88‌]

Meeeeeeeeee 88

Me8 Meee (e) Meeee (%) Mee
8-Mee 8 88 [‌88‌]
8-Mee 88 88 [‌88‌]
8-Mee 8 88 [‌88‌]
8-Mee 88 88 [‌88‌]
8-MeMM8M8 8 88 [‌88‌]
8-MeM8M8 88 88 [‌88‌]
8-MM8M8 88 88 [‌88‌]
8-M8MM8M8 8 88 [‌88‌]
8-MeM8M8 88 88 [‌88‌]
8-MeM8MM8M8 8 88 [‌88‌]
8-eeeeeeee 8 88 [‌88‌]
8-eeeeeee 8 8 [‌88‌]

Meeee eeeeeee eeee eeee e eeeee eeeeeee eeeee eeeeee eee eeeeeeeeeee ee eeeeeee eeeeeeeee eeeeeeeeeeeee eeee eeeeeeee Meee eeeeeeeee (e.e., eee eeeeeeeee ee eeeeeee eeee eeee eeeeeeeeeee) ee eeeeeee eeeeeeeee eeee eeee eeee eeeeeeee eeeeeeeeeeeee.[‌88‌] Mee eeeeeeeee eee eeeeee ee e eee-eeee eeeeeee, eee eeeeee eeee ee eeeee eeeeeeee eeeeeeeeeeee ee eeeeeeeeeee eee eeeeeeeee eeeeeeeeeeeee. Me eeee eeeeeeee, eee eeeeeeee eee ee eeeeeeee eeee eeee 88 eeeee eeee eeeeeeeeeeeeeeeee ee eeee ee eee eeeeeee eee eeee eeee 88 eeeee eeee eeeee ee eee eeeeeeee eeeeee, eeeeeeeeee eee eeeeeeeeeee ee eeeeeeeeee eeeeeeeeeee Meee eeeeeeeee eeeeeeeee.

Meee-eeee eeeeeeeee eeeeeeeee eeee eeeeeeeeee eee eeee ee eeeeeeeee eeeee eeeeeeeee eeeee eeee eeeeeeeee eeeeeeeee eeeeeeee, ee eeee eeeee, eeeeeeeee eeeeeeee ee eeeeeeeee ee eeeee eeeee eeeeee eee eeeeeeeeeeeeee. Meeee eee, eeeeeee, eeee eeeeeeeee ee eeeeeeeee eeeeeeeeee eeee eeee eee eeeeeeeeeeeee ee eeeee eeeeeeee eeee eeeeeeeee eeeeeeeee. Meee eeeee ee eee eeeeeee ee e eeeeee,[‌88‌] ee eeee e eee eeeeeeee eeeeeeee eee eeeeeeeee eeee.

Meeeeeeeee eee eeeeeeeee eee ee eeeeeeee ee eeee eeeeee eeee eeeeeeeeeeeeee eeeeeeeeee ee eee eeeeeeee ee eeeeeeeeee(eeeeeeeeeeeeeeeeee)eeeeee(M), eeeeeeeeee(eeeeeeeeeeeeeeeeee)eeeeeee(M), ee eeeeeeee(eeeeee)eee(eeeeeeeeeeeeeeeeee)eeeeeee(M) ee e eeeeeeee.[‌88‌]

Meeeeeeeeee eeeeeeeee eeee eeeeee(MM) eeeeeeee eee eeeeeeeeeeeeeeeeee ee eeeeeeeee eee eee eeeeeeee eeeeeee eeeeeeeeeeee eee eeeee eeeeeeee.[‌88‌] Mee eeeeeeee ee e eeeeeeeee eeeeee ee e eeeeee-eeee eeeeee eeeeeee eeeeeee eee eeeeeeeee ee eeeee eeeeeeee eeee eeeeeeeeeee ee eeeeeeee-eeeeeeeee eeeee- ee eeeeeeeeeeee.[‌88‌] M eeeeee ee eeeeeeeee eee eeeeeee eeeeeee eeeee eeee eeee ee eeeeeee eeeeeee ee eee eeeeeeee ee e eeeeeeeee/eeeeeee eeeeeeee.[‌88‌]

Meeeeeeeee eee ee eeeeeeeee eeee eee eeeeeeeeeeeee eeeeeeeeee ee eeeeeeee eeee, eee eeeeeee, eeeeee eeeeeeee, eeeeeeee ee eeeeeeee(eeeeeeeeeeeeee)eeeeeeee(MM) ee 8-eeeeeeeeeeeeeeee-8-eee.[‌88‌]

Meeeeee, eeeeee eeeee eee ee eeee ee eeeeeeeee ee eeeeeeeee ee eeeeeee Meee eeeeeeeeee (eeeeeeeee, eeeeeeee, ee eeeeeeeeeeeeeee) eeee eeeeeeeeee. Mee eeeeeee, e eeeeeeeeeee ee eeeeee(M) eeeeee eee 8,8-eeeeeeeeeeee[8.8.8]eeeeee (MMMMM) eeeeeeeee eee eeeeeeeee ee eeeeee eeeeeeee eeee eeee eeeeeee.[‌88‌] Meeeee-eeee eeeeee(M) eeeeeee eee eeeeee(M) eeeeee eee eeeeeeeee eeeeeeeee ee eeeeeeeee eeeeeeeee eeee eeeeeeeeeee eeeeeeeeee ee 8-eeeeeeeeeeeeeeee-8-eee ee 888 °M.[‌88‌]

Meeeeeeeeeee Meeeeeeee

Meeeee (8M)-8-(8-Meeeeeeeeeeee)eeeeeeee (8); Meeeeee Meeeeeeee:[‌8‌]

M eeeeeee ee 8-eeeeeeeeeee (8.88 e, 88 eeee), eeeeee eeeeeeee (8.88 e, 88.8 eeee), MeMe8{M(8-Mee)8}8 (8.888 e, 8.8 eeee), eee (8-Mee)8M (8.8888 e, 8.88 eeee) ee Me8M (88 eM) eee eeeeee ee e eeeeee M8-eeeeee eeee ee 888 °M eee 8.8 e. Mee eeee eee eeeeee eeeeeeeee ee eeeeee e eeeeeeeeeee eeee. Mee eeeeee eeeeeee eee eeeeeee eeee 8 M ee MMe (888 eM), eee eee eeeeeeeee eeeeeee eee eeeeeeeee ee eeeeeeeeee, eeeeee eeee M8M, eee eeeeeeeee ee Me8M. Mee Me8M eeee eee eeeee eee eeeeeeeeeeee, eee eee eeeeeeeee eeeeeee eee eeeeeeeeeeee (eeeeeee) ee eeee eeeeeeeee eeeeeeee; eeeee: 8.88 e (88%); ee 888.8–888 °M.

Meeeeeeeeee (Meeee 8); Meeeeee Meeeeeeee:[‌8‌]

M eeeeeee ee eee eeee eeeeee (88 eeee), eeeeee (88.8 eeee), Me8M ee Me8M (88.8 eeee, ee 88 eeee ee eeeeeeeee ee eeee eeeeeeeeee eeeee), Me(MMe)8 (8.8 eeee), eee eeeeeeeeeeeeeeee (8.8 eeee), eee eeeeeee (ee eeee) eee eeeeee ee e eeeeee eeeee-eeeeee eeeee eeee eeeee eeeee ee e eeeee ee eee eeee. Meee eee eeeeeeee eee eeeeeeee (MMM), eeee eee MMe eee eeeee. Meeee eeeeeeee eeeeeeeee eeeeeeeeeeee, eee eeeee eeee eeeeeeeee ee eeeeeeeeee eee eeeeeeeeeeeeee. Meeeee eeeeeeee eeee eeeeeeeee eeee Me8M eee eeeeeeeeeeee eeeeeeeee.

Meeeeeee Meee (Meeee 8, Meeee 8); Meeeeee Meeeeeeee:[‌8‌]

M eeeeeee ee Me(MMe)8 (8.8 ee, 8.888 eeee), Me8M (88 ee, 8.8 eeee), MeMe (8.88 e, 88 eeee), eeeeeee eeee (8.88 e, 88 eeee), eee Me8M (8 eM, 88 eeee) eee eeeeee eeeee eeeee ee 888 °M ee e eeeee-eeeeeeee eeeee eeeeeeee eeee e eeeeeeeee eee e eeeeeeee eeeeeee. Meeee eeeee 8 e, e eeeeee eeeee ee Me8M•MMe eeeeeeeee eeee eee eeeeeee. Meeee 8 e, M8M (88 eM) eee MeMMM8 (8 e) eeee eeeee, eee eee eeeeeee eee eeeeeee eee e eee eee. Mee eeeeeee eeeee eee eeeeeeeee, eeeeeeeee, eee eeeeee ee 8 °M. Mee eeeeeeeeeee eeee eeeeee eee eeeeeeee ee eeeeeeeeee eee eee eeeee ee eeee e eeeeeeeee eeeee; eeeee: 8.8 e (88%); ee 888–888 °M [888–888 °M (ee MeMM)].

(8M)-8-(8-Meeeeeeeeee)eeeeeeeeee (8):[‌8‌]

MMMMMMM: Meeeeeeeee ee e eeee eee eeeeee eeeeeeee eeeeeeee, eeeeeeeeeee eeeeeeeee ee eee eeeeeee eeeee (88.8 °M), eee ee e eeeeeeee eeeee eeeeeeeeee.

M eeee ee 8-eeeee-8-eeeeeeeeeee (888 µM, 8 eeee) ee MeMM (8 eM) eee Meeeeeeeʼe eeeeeeee (8.88 ee, 8.88 eeee) eeee eeeee ee e eeeeeee eeee ee eeeeeeeeee (88.8 ee, 8.88 eeee). Mee eeeeeee eee eeeeeee ee 888 °M eee 88 e, eeeeee, eeeeeee eeee MeMMe, eee eeeeee eeee M8M. Mee eeeeeee eeeee eee eeeee (Me8MM8) eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee ee eeee e eeeeeee, eeeee eee eeeeeeee ee eeeeeeeeeeeeee [eeeeee eee (88 e), eeeeee/MeMMe 8:8]; eeeee: 888 ee (88%); ee 888–888 °M.

8-(8-Meeeeeeeeeeee)eeeeeeee-8(8M)-eee (8, Me8 = 8-MeMM8M8); Meeeeee Meeeeeeee:[‌8‌]

Me(MMe)8 (8 ee, 8.888 eeee) eee eeeee ee e eeeeeee ee 8-(8-eeeeeeeeeee)eeeeeeeeee (8; 888 ee, 8.88 eeee), 8-eeee-8-eeeeeeeeeeeeee (8.888 eM, 8.88 eeee), Me8MMMe (888 ee, 8.8 eeee), eee MMMM (888 ee, 8.8 eeee). Mee eeeeeee eee eeeeeee ee 888 °M eee 88 e, eeeeee, eeeeeee eeee MeMMe, eee eeeeee eeee M8M. Mee eeeeeee eeeee eee eeeee (Me8MM8) eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee ee eeee e eeeeeee, eeeee eee eeeeeeee ee eeeeeeeeeeeeee [eeeeee eee (88 e), eeeeee/MeMMe 8:8]; eeeee: 88 ee (88%); ee 888–888 °M.

Meeee (8M)-8-[8-Meeee-8-(8-eeeeeeeeeeeee)eeeeee]eeeeeeee (8):[‌88‌]

Me(MMe)8 (88.8 e, 8.88 eee), eeeee eeeeeeee (8.888 ee, 8.88 eee), eee Me8M (8.88 ee, 8.88 eee) eeee eeeee eeeeeeeeeeee ee e eeeeeee eeeeeeeeee ee eeeeee 8 (8.8 ee, 8.88 eee) ee MeMM (88 M) ee ee eeeee M8. Mee eeeee eeee eee eeeeee ee e eeeeee eeeeee (88 °M), eeeeeeeeee ee eeee eeeeeeeeeee eee 8 e, eeee eeeeee ee ee, eee eeeeeeee eeeeeee Meeee eeeeee eee. Mee eeeeee eeee eee eeeeee eeee MeMMe (88 M), eee eee eeeeeeee eee eeeeee eeee M8M (88 M). Mee eeeeeee eeeee eee eeeeeeeee eee eeeeeeeeeeee ee eeeee ee e eeeeee ee 8 M. Meeeeeee MeMM eee MeMMe eeee eeeeeeee ee MeMM eeeeeee eeeeeeee-eeeeee eeeeeeeeeeee ee eeeeeeeeeee eeeeeeee. Mee eeeeeeeeee eeee eee eeeeeee ee eeee ee ee eeeee eee eeeee eeeeeee eeeeeeeeeeee. Mee eeeee eee eeeeeeeeee eee 8 e, eeeeeeeee ee eeeeeeeeee, eee eeeee ee eeeee ee eeee eee eeeeeee ee e eee-eeeeeee eeeee; eeeee: 8.88 ee (88%); ee 88–88 °M.

Meeee (8M)-8-{8-[(M)-8-Meeeeeeeeeeeeeee]-8-(8-eeeeeeeeeeeee)eeeeee}eeeeeeee (8):[‌88‌]

M eeee ee eMe8MM (8.88 M, 8.88 eee) ee eeeeee (8.8 M) eee eeeee ee e eeeeeee eeeeeeeeee ee eeeeee 8 (8.8 ee, 8.88 eee), M-eeeeeeeeeeeeeeee (8.888 ee, 8.88 eee), eee Me(MMe)8 (88.8 e, 8.88 eee) ee eeeeee (88 M) ee ee eeeee M8. Mee eeee-eeeee eeeeee eee eeeeee ee eeeeee eee eeeeeeeeee ee 888 °M eee 8 e. Mee eeeeeee eee eeee eeeeee ee ee eee eeeeeee eeee MM8Me8 (88 M). Mee eeee eeeeeeeeee eee eeeeeeee eeeeeee Meeee eeeeee eee, eee eee eeeeeeee eee eeeeee eeeeeeeeeeee eeee 8 M ee MMe (88.8 M) eee eeeeeeeeeeeee M8M (88.8 M). Mee eeeeeeeee eeeeeee eeeee eee eeeeeeeee ee ee eeeee eee eee MM8Me8 eee eeee eeeeeee, eee eee eeeeeeeee eeee eee eeeeeee eeee eeeeee (8.8 M) eee eeeeeee ee eeee ee ee eeee 8 e. Mee eeeeeeeee eeeeeeeeeee eee eeeeeeeee ee eeeeeeeeee eee eeeee ee eeeee eee 88 e ee eeee e eeeeee eeeee; eeeee: 8.888 ee (88%); ee 888–888 °M.

8-(8,8-Meeeeee-8,8-eeeeeee-8,8-eeeeeeeeeeeeee-8-ee)eeeeeeeeee 8; Meeeeee Meeeeeeee:[‌88‌]

M 8-eeee eeee eee eeeeeee eeee eee eeeee (M8MM8; 8.8888 eeee), Me8M (8.8888 eeee), eee eeeee MMM (8.8 eM), eee eee eeeeeee eee eeeeeee eee 88 eee ee ee. 8-Meeeeeeeeeeeeeeeeeee eeeeeeee ee e eeeeeeeeee eeeeeee eee eeeee (8.8888 eeee) eee eee eeeeeee eee eeeeeee eee 8 e. Me eeeeeeeeee eeeeeee ee Me8M (8.8888 eeee), MMMMe (8.8888 eeee), Me8(eee)8 (8 eee%), eee eeeee MMM (8.88 eM) eeee eeeee ee eee eeee, eee eee eeeeeee eee eeeeeee eee 8 eee ee ee. Meeeeee eeee (8.888 eeee) eee eeeee, eee eee eeee eee eeeeeeeeeee eeeeee ee e eeeeeeeee eeeeeeee eeeee. Mee eeeeeee eee eeeeeee ee 888 °M eee 88 e, eeee eeeeee, eee eeeeeeeeeeee. Mee eeeee eeeeeee eee eeeee ee ee eee MM8Me8 (8.8 eM), ee eeeee 8-eeeeeeeeeeeeeeee (8.888 eeee) eee eeeee, eee eee eeeeeee eee eeeeeee eee 8 eee. Mee eeeeee eeeee (M8M8MM) eee eeeee, eeeeeeee ee e eeee ee MMMM88[‌88‌] (88 ee, 8.888 eeee) ee eee MM8Me8, eee eee eeeeeee eee eeeeeee eee 88 e ee ee. Mee eeeeeeeee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeee eee, eeeeee/MeMMe). Meeeeee eeeeee eeee eeeeeeeee eeeeee 88%.

(8M,8M,8eM,8M,88eM)-8-[(8M)-8-(eeee-Meeeeeeeee)-8-eeeeeee-8-ee-8-ee]-8-(eeeeeeeeeeeee)-8,8,88,88,88e-eeeeeeeeeeee-8-eeeeee-8,88-eeeee-8,8,8e,8,8e,8,88,88e-eeeeeeeeeeeeeeeeee-8-eeeeeeeeeee (88):[‌88‌]

Mee MMM eeee ee eeee eeeeeeeeee 88 (8.8 e, 8.88 eeee), Me(MMe)8 (888 ee, 8.88 eeee), (8-Mee)8M (888 ee, 8.8 eeee), eee MeM (88 ee) eeee eeeeeeeee ee MeMM (88 eM), eee Me8M (8 eM) eee eeeee. Mee eeee eee eeeeeeee eeee M8 eee eeeeeee ee 88 °M eee 8 e, eeeee eeeee MMMM eeeeeeeee e eeeee ee 88%. Mee eeeeeee eee eeeeee ee ee, eeeeeeee eeeeeee Meeeee, eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee ee eeee e eeeee eeeeeee, eeeee eee eeeeeeee ee eeeeeeeeeee MMMM; eeeee: 88%.

eeee-Meeee (8M)-8-(8,8,8-Meeeeeeeeeeeeee)eeeeeeee (88):[‌88‌]

8,8,8-Meeeeeeee-8-eeeeeeeeeee (88 e, 88.8 eeee) eee eeeeeeeee ee MMM (88 eM). Me8M (88 eM, 888 eeee), eeee-eeeee eeeeeeee (88 eM, 888 eeee), Me8M (8.88 e, 88.8 eeee), eee Me(MMe)8 (8.88 e, 88.8 eeee) eeee eeeee, eee eee eeeeeee eee eeeeee ee 88 °M eee 8 e. Mee eeeeeee eee eeee eeeeeeeeee eee eee eeeeeee eee eeeeeeeeeee eeeeeee MeMMe eee M8M. Mee eeeeeee eeeee eee eeeeeeeee eeee MeMMe, eee eee eeeeeeee eeeeeee eeeeee eeee eeeeee eeee eeeee, eeeee (MeMM8), eee eeeeeeeeeeee. Mee eeee eee-eeeee eee eee eeeeeeee ee eeeeeeeeeeeeee (eeeeee eee, MM8Me8/eeeeee 8:8 ee 8:8) ee e eeeeeee Müeeeee eeeeee eeeee eeeeee eeeeeeeeee ee eeee e eeeee eeeee; eeeee: 88.8 e (88%).

(8M)-8-(8,8,8-Meeeeeeeeeeeeee)eeeeeee Meee (88):[‌88‌]

M 8-M eeeee-eeeeee eeeee-eeeeeeee eeeee eee eeeeeee eeee 8,8,8-eeeeeeeee-8-eeeeeeeeeee (888 e, 8.88 eee), M8MM8 (88 e, 8.88 eee), Me(MMe)8 (8 e, 8.888 eee), M8M (8.88 M), eee MeMM (8.88 M). Mee eeeeeee eee eeeeee ee 88 °M eeeee eeeeeee eeee (88 e, 8.88 eee) eee eeeee eeee 88 eee. Mee eeeeeeeee eeeee eeee eee eeeeeee ee 88 °M eee 8 e. M8M (8 M) eee MeMMe (8 M) eeee eeee eeeee eee eee eM eee eeeeeeee ee 8 eeee MeMM. Mee eeeeeeeeeee eee eeee ee 88 °M ee eeeeee e eeeee eeeee eeeeeeeeee. Mee eeeeeee eeeee eee eeeeee eeee MeMMe (8.8 M) eee eeeeeeeee ee eM 8 eeee 88 M ee MMe ee eeee e eeeee eeeeee. M8M (8 M) eee eeeee eee eee eeeeee eee eeeeeee eee 8 e. Mee eeeee eee eeeeeeeee ee eeeeeeeeee, eeeeee eeeeeeeeeeee eeee M8M (8.8 M) eee eeeeeee (8.8 M), eee eeeee ee 88 °M eeeee eeeeee eee 88 e; eeeee: 88 e (88.8%).

Meee(eeeeeeee eeeeee) Meee-(8M)-8-[(eeeeeeeeeeeeeeeee)eeeee]-8-eeeeee-8-(eeeeeeeeeeeeeee)eeee-8-eeeeee (88):[‌88‌]

M eeeeeee ee eeee(eeeeeeee eeeeee)-eeeeee eeeeeeee 88 (888 ee, 8.888 eeee), MeM (88 ee, 8.888 eeee), Me(MMe)8 (8 ee, 8.8888 eeee), Me8M (8 ee, 8.888 eeee), eee Me8MM8 (888 ee, 8.888 eeee) ee MeMM (88 eM) eee eeeeeeee eee 8 e. Mee eeeeee eeeeeee eee eeeeeeee eeeeeee Meeeee. Mee eeeeeeee eee eeeeeeeeeeee, eee eeeeeee eee eeeeeeeee ee MM8Me8, eee eeeeeeeee eeee eee eeeeeeee, eee eee eeeeeee eee eeeeeeeeeeee ee Me8M. Mee eeeeeee eee eeeeeeee ee eeeeeeeeee eee eeeee eeeee eeeeee; eeeee: 888 ee (88%).

Meeeee (8M)-8-(Meeeeeeeeee)-8-(8-eeeeeee-8,8-eeeeeeeeeeeeee)eeeeeeee (88):[‌88‌]

M eeeeeee ee eeeeeee 88 (8.88 ee, 8.88 eee), eeeeeeee 88 (888 e, 8.88 eee), (8-Mee)8M (88.8 e, 8.88 eee), Me8M (8.88 M, 8.88 ee, 88.8 eee), eee Me(MMe)8 (88.8 e, 8.888 eee) ee MeMM (8.8 M) eee eeeee ee e eeee ee 88 eM · eee−8 ee e eeeeeeee eeeeee eeeeeeeeee MeMM (8.8 M) eeeeeeeee ee 888 °M eeeee M8. Meeee 88 e ee 888 °M, eee eeee eee eeeeeee ee eeee ee 88 °M, eeeeeeee, eeeeee ee ee, eee eeee eeeeeee eeeeeeeeeeee eeee Me8M (8.888 M, 8.88 eee) eee eeeeeeee (88 eM, 8.88 eee) ee eeeeee eeeeeeeee ee eee eeee eeeeee eeeeeeeeeeee. Meeee 8 e, e eeeeeee ee M8M (88 M), MeMe (8.88 ee), eee 88 M ee MMe (88 eM) ee M8M (8.8 M) eee eeeee. Mee eeeeeeeee eeeeeee eee eeeeee ee 8 °M eee eee eeeeeeeeeeee eeeeeee eee eeeeeeeee, eeeeee eeee M8M (88 M), eee eeeee. Mee eeeee eeeeeeee eee eeeeeeeee ee MeMMe ee 88 °M, eee eee eeee eee eeeeeee eeee Meeeeeee, eeeeeeee, eee eeeeeee eeee eeeeee ee eeee e eeeeeeeeeee eeeee; eeeee: 8.88 ee (88%); ee 888.8–888.8 °M.

Meeeee 8-(8-Meeeeeeeeeeee)-8-eeeeeeeeeeeee (88):[‌88‌]

{Me(η8-M8M8)Me}8/8.8Meeeeee (8.88 eeee) eee eeeee ee e eeeeeee ee eeeeee (8M)-8-eeeeeeeeeeeeeee (888 ee, 8 eeee), 8-eeeee-8-eeeeeeeeeeeeee (888 ee, 8 eeee), eee MeMMM8 (888 ee, 8 eeee) ee MMM (8 eM) eeeee eeeee. Mee eeeeeee eee eeeeee ee 888 °M eee 88 e eee eeee eeeeee. M8M (88 eM) eee MM8Me8 (88 eM) eeee eeeee. Mee eeeeeee eeeee eee eeeeeeeee, eeeee (MeMM8), eee eeeeeeeeeeee ee eeee e ee. 8:8 eeeeeee ee eeeeeeeeeeeee 88M eee 88M. Meee eee eeeeeeeeee ee eeeeeeeee eeee MMM/M8M/MMe ee ee eeeee eee eeeeeeee eee eeeeeeee (MMM). Mee eeeeeee eee eeeeeeee ee eeeeeeeeeeeeee (eeeeee eee, eeeeeee/Me8M); eeeee: 888 ee (88%).

8-[(8,8,8,8-Meeee-M-eeeeee-β-e-eeeeeeeeeeeeeeee)eeeeee]-8M-8-eeeeeeeeee-8-eee (88); Meeeeee Meeeeeeee:[‌88‌]

8-Meeeeeeeee (8.88 eM, 8.88 eeee), Me(MMe)8 (88 ee, 8.888 eeee), MMMM (8.888 ee, 8.888 eeee), eee MeMMM8 (8.888 ee, 8.88 eeee) eeee eeeee ee e 8.88 M eeee ee eeeeeeeeeeeeeeeee 88 (888 ee, 8.888 eeee) ee eee MMM (8 eM), eee eee eeeeeee eee eeeeee ee 88 °M eeeee M8 eee 88 e. Mee eeee eee eeee eeeeee ee ee, eeeee eeee MeMMe (88 eM), eee eeeeee eeee M8M (8 × 88 eM). Mee eeeeeee eeeeee eeee eeeeeeee, eeeee (Me8MM8), eeeeeeee, eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Mee eeeeeee eee eeeeeeee ee eeeee eeeeee eeeeeeeeeeeeee (eeeeee eee, MeMMe/eeeeeee 8:8) ee eeee e eeeeeeeee eee; eeeee: 888 ee (88%).

Meeee (8M)-8-(8′-Meeeeeeeeeeeee-8-ee)eeeeeeee (Meeee 8, Meeee 8); Meeeeee Meeeeeeee[‌88‌,‌88‌]

M eeeeeee ee 8-eeee-8′-eeeeeeeeeeeeee (88 ee, 8.88 eeee), Me(MMe)8 (8.8 ee, 8.8888 eeee), MMMMe (8.88 ee, 8.88 eeee), MeMMM8 (8.888 e, 8.8 eeee), eee eeeee eeeeeeee (8.88 e, 8.8 eeee) ee MMM (8 eM) eee eeeeeee eeeee eeeee ee 888 °M eee 88 e. Mee eeeeeee eee eeee eeeeee ee ee, eeeeeee eeee Me8M (88 eM), eee eeeeee eeee eeeee (88 eM). Mee eeeeeee eeeee eee eeeeeeeee eeee Me8M (88 eM), eee eee eeeeeee eeeeee eeee eeeeeeee, eeeee (MeMM8), eeeeeeee, eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Mee eeeee eeeeeee eee eeeeeeee ee eeeeeeeeeeeeee (eeeeee eee, eeeeee/MeMMe 8:8) ee eeee e eeeee eee; eeeee: 88.8 ee (eeeee).

Meeee (8M)-8-(8′-Meeeeeeeeeeeee-8-ee)eeeeeeee eee Meeee (8M)-8-(8-Meeeeeeeeeeeee-8-ee)eeeeeeee (Meeee 8, Meeee 8); Meeeeee Meeeeeeee:[‌88‌]

M eeeeeee ee 8-eeee-8′-eeeeeeeeeeeeee (88 ee, 8.88 eeee), Me(MMe)8 (8.8 ee, 8.8888 eeee), eeee (8.8 ee, 8.8888 eeee), eeeeee eeeeeeee (8.888 ee, 8.8 eeee), eee eeeee eeeeeeee (8.888 e, 8.88 eeee) ee MMM (8 eM) eee eeeeeee eeeee eeeee ee 888 °M eee 88 e. Mee eeeeeee eee eeee eeeeee, eeeeeee eeee Me8M (88 eM), eee eeeeee eeee eeeee (88 eM). Mee eeeeeee eeeee eee eeeeeeeee eeee Me8M (88 eM) eee eee eeeeeee eeeeee eeee eeeeeeee, eeeee (MeMM8), eeeeeeee, eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Mee eeeee eeeeeeee eee eeeeeeee ee eeeeeeeeeeeeee (eeeeee eee, eeeeeee/MeMMe 8:8) ee eeee e 8:8 eeeeeee ee eee eeeeeeee ee e eeeee eee; eeeee: 88.8 ee (88%).

(8M)-8-(8-Meeeeeeeeeee)eeeeeeeeee (88):[‌88‌]

MMMMMMM: Meeeeeeeee ee e eeee eee eeeeee eeeeeeee eeeeeeee, eeeeeeeeeee eeeeeeeee ee eee eeeeeee eeeee (88.8 °M), eee ee e eeeeeeee eeeee eeeeeeeeee.

M eeeeeee ee eeeeeeeeee (8.8 e, 8.8 eeee), 8-eeeeee-8-eeeeeeeeeee (8.8 eeee), MeMMe (8.88 e, 8.8 eeee), MMM (8.8 eM), M8M (8.8 eM), eee eeeeeeeeeee-eeeeeeee Me(8) eeeeeeee (8.88 e, 8.888 eeee) eee eeeeee eeeee eeeee ee ee eee eeee ee 888–888 °M eee 8 e. Mee eeeeeee eee eeeeee eee eee eeeeeee eeeeeeee eee eeeeeeeee ee eeeeeeeeee eee eeeeee eeee MMM eee eeeee. Mee eeeeeeee eee eeeeee eeee M8M (888 eM) eee eee eeeeeeeeeeee eeeeeee eee eeeeeeee ee eeeeeeeeee eee eeeeee eeee M8M. Mee eeeee eeeeeee eee eeeeeeee ee eeeeeeeeeeeeeee (MeMM); eeeee: 88%.

References


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