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DOI: 10.1055/sos-SD-210-00001

Müller, T. J. J.Science of Synthesis: Multicomponent Reactions, (201411.

The science of synthesis has reached a tremendous level of highly sophisticated complexity and almost any kind of conceivable molecule can nowadays be synthesized. Conceptually, the art of synthesis is predominantly practiced in the sense of the transformation of a substrate and a reactant, i.e. in a two-component fashion, for accessing natural and nonnatural target molecules in a series of many individual two-component reactions. These reaction steps represent an ongoing economic and practical challenge for organic synthesis, and the past half-century has witnessed an enormous rise in powerful novel methodologies that enable synthetic chemists to create complex molecules more elegantly, more efficiently, and more rapidly.

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