Science of Synthesis

Müller, T. J. J., Science of Synthesis: Multicomponent Reactions, (2014) 1, 7.

In all one-pot methodologies, a reactive functionality has to be created by the preceding reaction step to be transformed in a subsequent process within the same reaction vessel. This means there is no separation in space and time as in flow methodologies, but everything has to be compatible with a certain set of reaction conditions, which were chosen with the first elementary step. Mechanistically, multicomponent reactions are concatenations of elementary steps which can adopt a complex kinetic scenario. In many cases, mechanistic approaches, especially in methodological studies, have been made by considering individual presumably rate-limiting steps for scrutinizing the optimized reaction conditions within the context of the whole sequence. Yet, for a deeper understanding of multicomponent reactions as a reactivity-based concept, it is necessary to consider the modes of organic reactivity.

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