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1.2.1.1 Third Component 1,3-Dicarbonyl Compound (with Ureas: Biginelli Reaction)

DOI: 10.1055/sos-SD-210-00011

Chebanov, V. A.; Gorobets, N. Yu.; Sedash, Yu. V.Science of Synthesis: Multicomponent Reactions, (2014129.

General Introduction

The three-component Biginelli[‌1‌] condensation is today one of the most studied multicomponent reactions and is widely used for the construction of diverse molecules containing 3,4-dihydropyrimidin-2(1H)-one and 3,4-dihydropyrimidine-2(1H)-thione heterocycles [DHPMs; alternative names: 3,4-dihydro-2(1H)-pyrimidin(ethi)ones, 2-(thi)oxo-1,2,3,4-tetrahydropyrimidines]. To date there are more than 1000 publications on the Biginelli reaction and the number of reviews concerning this multicomponent reaction is approaching 100. Such high research interest is explained by the simple methodology and efficiency of this multicomponent reaction for diversity-oriented and focused synthesis. Furthermore, this reaction and its products are often used as models for testing novel catalytic systems,[‌2‌,‌3‌] process-intensification techniques,[‌4‌‌9‌] methods for separation of enantiomers,[‌10‌,‌11‌] and other newly introduced chemical technologies.[‌12‌,‌13‌]

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References