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1.2.1.4.4.1 Betti Reaction in Alcoholic Solvents

DOI: 10.1055/sos-SD-210-00078

Bernardi, L.; Ricci, A.Science of Synthesis: Multicomponent Reactions, (20141155.

As in the original protocol,[‌51‌] the Betti reaction between alcoholic ammonia, benzaldehydes, and 2-naphthol gives initially an equilibrating mixture of imine and oxazine tautomeric adducts, containing two aldehyde units. Acidic hydrolysis then leads to formation of the stable hydrochlorides, from which the free bases 30 can be obtained by basification with an aqueous ammonium hydroxide solution (Scheme 34).[‌52‌]

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Me8 Meeeee (%) Mee
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8-MeM8M8 88 [‌88‌]
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M8 Meeee (e) Meeeee (%) Mee
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8-(8-Meeeeeeeee)eeeeeeeeee-8-ee Meeeeeeeeeeeee 88; Meeeeee Meeeeeeee:[‌88‌]

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References


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