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1.2.1.7 Third Component Boronic Acid (Petasis Reaction)

DOI: 10.1055/sos-SD-210-00137

Carboni, B.; Berrée, F.Science of Synthesis: Multicomponent Reactions, (20141219.

General Introduction

Over the past four decades organoboranes have become essential building blocks in modern synthetic organic chemistry. In addition to being regarded as particularly valuable partners in numerous targeted syntheses, they have also recently found some very interesting applications in several multicomponent reactions, a rapidly evolving field of research.[‌1‌,‌2‌] Key advantages of using boronic esters and their derivatives, as compared to other organometallic reagents, include the configurational stability of alkenylboron species, the preservation of the stereochemical integrity in the final product, compatibility with a broad range of functional groups, low environmental impact, and easy separation of residual boron byproducts.[‌3‌] The commercial availability of numerous boronic acids, esters, and, more recently, potassium trifluoroborates, has also greatly contributed to the popularity of these reagents among organic chemists.

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References