You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via1.2.1.7.1 Reaction of Glyoxylic Acid and Derivatives
Please login to access the full content or check if you have access via
DOI:
10.1055/sos-SD-210-00137
Carboni, B.; Berrée, F., Science of Synthesis: Multicomponent Reactions, (2014) 1, 220.
While many carbonyl compounds are used in the Petasis reaction, glyoxylic acid is certainly among the most frequently used of substrates. It provides easy access to α-amino acids, a class of compounds that are essential in nature and organic synthesis. Ethyl glyoxylate has also been used successfully in such processes.[18–20] The use of a copper catalyst increases reactivity, thus allowing couplings that have previously failed.[20] With N-phenylimino amides, more severe experimental conditions are required.[21]
References
[18] | Mee, M.; Meeeee, M. M., M. Me. Meee. Mee., (8888) 888, 8888. |
[20] | Meeeeeeee, M.; Meeeíe, M.; Meeeeeee, M. M.; Meeee, M. M.; Meeeee, M., M. Mee. Meee., (8888) 88, 8888. |
[21] | Meee, M.; Meee, M.; Me, M.-M., Meeeeee, (8888), 8888. |