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1.2.1.7.1 Reaction of Glyoxylic Acid and Derivatives

DOI: 10.1055/sos-SD-210-00137

Carboni, B.; Berrée, F.Science of Synthesis: Multicomponent Reactions, (20141220.

While many carbonyl compounds are used in the Petasis reaction, glyoxylic acid is certainly among the most frequently used of substrates. It provides easy access to α-amino acids, a class of compounds that are essential in nature and organic synthesis. Ethyl glyoxylate has also been used successfully in such processes.[‌18‌‌20‌] The use of a copper catalyst increases reactivity, thus allowing couplings that have previously failed.[‌20‌] With N-phenylimino amides, more severe experimental conditions are required.[‌21‌]

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