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1.2.3.1.1.2.1 Passerini Reactions under High Pressure

DOI: 10.1055/sos-SD-210-00185

Riva, R.; Banfi, L.; Basso, A.Science of Synthesis: Multicomponent Reactions, (20141329.

In certain cases the use of high hydrostatic pressure has been shown to dramatically increase the yield in reactions involving bulky ketones.[‌19‌] For example, the reactions of tert-butyl isocyanide with acetone and pivalic acid or 3-methylbutan-2-one and 4-methylbenzoic acid give only 2 and 5% yield, respectively, when carried out at atmospheric pressure; the yields rise to 52 and 39%, respectively, when employing high hydrostatic pressure (Scheme 3).

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