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DOI:
10.1055/sos-SD-210-00185
Riva, R.; Banfi, L.; Basso, A., Science of Synthesis: Multicomponent Reactions, (2014) 1, 329.
In certain cases the use of high hydrostatic pressure has been shown to dramatically increase the yield in reactions involving bulky ketones.[19] For example, the reactions of tert-butyl isocyanide with acetone and pivalic acid or 3-methylbutan-2-one and 4-methylbenzoic acid give only 2 and 5% yield, respectively, when carried out at atmospheric pressure; the yields rise to 52 and 39%, respectively, when employing high hydrostatic pressure (Scheme 3).
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References
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