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DOI: 10.1055/sos-SD-210-00242

Wessjohann, L. A.; Kaluđerović, G. N.; Neves Filho, R. A. W.; Morejon, M. C.; Lemanski, G.; Ziegler, T.Science of Synthesis: Multicomponent Reactions, (20141416.

Classical Ugi reactions (Ugi four-component reactions; Ugi-4CRs) comprise the combination of carboxylic acids 1, primary amines 2, aldehydes 3, and isocyanides 4 in suitable solvents at specific temperatures to afford amino acid derivatives 5 (Scheme 2).[‌7‌] The classical Ugi reaction has found broad applications in peptide synthesis since there are virtually no restrictions as far as the structures of the four components are concerned, and yields of the Ugi products 5 are usually high.[‌6‌,‌8‌‌15‌] In general, highly nucleophilic amines, electron-rich aldehydes, and high concentrations of the reactants facilitate the reaction.[‌16‌]

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