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2.1.4.1.2 Primary and Secondary Amines

DOI: 10.1055/sos-SD-211-00055

Shaabani, A.; Sarvary, A.; Shaabani, S.Science of Synthesis: Multicomponent Reactions, (20142132.

The chemistry of enaminones has numerous attractive features that have made these compounds important building blocks in current organic synthesis.[‌61‌] They are versatile reagents that combine the ambident nucleophilicity of enamines with the ambident electrophilicity of enones, so they are suitable reagents for multicomponent reactions. Over the decades, multicomponent reactions of a primary or secondary amine, an α,β-unsaturated carbonyl compound, and a third component have provided elegant procedures for the synthesis of various heterocycles.

Mee eeeeeeee ee eeeeeeeee ee eeeeeeee eeeeee ee eeeeeeeee eeeeeeeeee α,β-eeeeeeeeeee eeeeeeee eeeeeeeee eeeee eeee eeeeee eeeeeeeeeeeee eeee eee ee eeee ee eeee ee e eeeeeeeee eeee ee eeeee ee eeeeeee, eee eeeeeee, e eeeeeee ee eeee-eeeeeee eeeeeeeee. Me eeee eeeeee, eee eeeeeeee ee eeeeee ee eeeeeeeeee eeeeeee eeeeeeeee eeeeeeeeeeeee 88, eeeee eeeee eeee eeeee eeeeeee ee eee eeeeeeee ee eeeeee(M) eeeeeeeeeeeeeeeee eeeeeeee eee (eeeeeeeeeeeee)eeeeeee eeeeeee, eeeeeee ee eeeeeeeeeeeeeee eeeeeeee 88 (Meeeee 88).[‌88‌] Meeeeeee eeeeee eeee eeeeeeee-eeeeeeeeeee eeeeee ee eeee eeeeeeee-eeeeeeee eeeeee eee eee eeeeeeee eee eeee eeeeeeee, eee eee eeeeeeee ee eeeee eeeeeeeee ee eee eeeeeeeeee eeeeeeeeeeee ee eee eeeeeeeeeee ee eee eeeeeee eeee. Mee eeeeeee, eee eeeeeeee eeee 8-eeeeeeeeeeeeee eeeeeee eee eeeeeeeeeeeee eeeeeee ee 88% eeeee, eeeeeee 8-eeeeeeeeeeeee eeeee eee eeeeeeee eeeeeee ee 88% eeeee. Meeeeeeeeeeee, eeeeeeeee eeeeee eeee eeeee ee ee eeeeeeee eeeeeeeeee.

Meeee eeeeeeeee eeeeeeeeee (8-eeeeeeeeeeeeeee, MeMM, ee) eee eeeeeee eeeee ee e eee-eeeeeeee eeee eeeeeee, eeeeeee eeeeeeeeeeeeee eeeeeee-8-eeee 88.[‌88‌] Meee eeeeee eeeeeeee eee eeee eeee eeeeeeeee eeeee eeeeeeeeeeeeeeeeee, eeeee eeeee ee eee eeeeeeeee ee eeeeee eeeeeeeeeeeeee eeeeeeeeee-8,8-eeeeee 88 eeee eeeeeeeeeeeeeeeeee eeeee ee e eeeeeeeee.[‌88‌]

Meeeee 88 Meeeeeee ee Meeeeeeee Meeeeeeeeeeee eeee Meeeeee ee eee Meeeeeee ee Meeeeee Meeeeeeee[‌88‌‌88‌]

Meeeeeeeeee 88

M8 M8 M8 M8 M8 Meeee (%) Mee
MM8Me Me Me MM8Me Me 88 [‌88‌]
MM8Me Me Me MM8Me Me 88 [‌88‌]
MM8Me Me 8-Mee MM8Me Me 88 [‌88‌]
MM8Me Me 8-MeMM8M8 MM8Me Me 88 [‌88‌]
MM8Me Me 8-MM8M8 MM8Me Me 88 [‌88‌]
MM8Me Me 8-MeM8M8 MM8Me Me 88 [‌88‌]
MM8Me Me Me MM8Me Me 88 [‌88‌]
MM8Me Me Me MM8Me Me 88 [‌88‌]
MM8Me Me Me MM8Me Me 88 [‌88‌]
M Me Me M Me 88 [‌88‌]
Me Me Me Me Me 88 [‌88‌]
MM8Me Me Me MM8Me Me 88 [‌88‌]
MM8Me Me Me MM8Me Me 88 [‌88‌]
MM8Me Me Me MM8Me M 88 [‌88‌]

Meeeeeeeeee 88M

M8 M8 M8 M8 M8 Meeee (%) Mee
MM8Me Me Me MM8Me Me 88 [‌88‌]
MM8Me Me 8-MeeMM8 MM8Me Me 88 [‌88‌]
MM8Me Me MMM MM8Me Me 88 [‌88‌]
MM8Me Me 8-MeM8M8MM8 MM8Me Me 88 [‌88‌]
MM8Me Me 8-MeMM8M8 MM8Me Me 88 [‌88‌]
MM8Me Me Me MM8Me Me 88 [‌88‌]
MM8Me Me Me MM8Me Me 88 [‌88‌]
MM8Me Me Me MM8Me Me 88 [‌88‌]

Meeeeeeeeee 88M

M8 M8 M8 Meeee (%) Mee
Me Me Me 88 [‌88‌]
Me MMM Me 88 [‌88‌]
Me 8-eeeeeeeeeeeeee Me 88 [‌88‌]
Me Me Me 88 [‌88‌]
Me Me Me 88 [‌88‌]

Meeeeeeee eee eeeee eeeeeeeeee eeeee-eeeeeeeee eeeeeeee eee eee eeeeeeeee ee eeeeeeeeeeeeeee eeeeeeee, eeeeeeeee eeeee eeeeeeeeee eee eeee eeeeeee eeeeeeeee eeee eeee eeeeeeee. Meeeeeeeeee eee ee-eeeeeee eeee eeeeeeee eee eeeeeeeee ee eeeeee eeeeeeeeeeeeee eeeeeeee 88 eeee eeeeee, eeeeeee eeeeeeeeeeeeeeeeeeeeeee, eee eeee eeeeeeee, eeeeeeee ee eeeeeeeeeeeeeeeeee ee eeeeeeeeeeeeeee ee eeee eeeeeeeeeee (Meeeee 88).[‌88‌] Meeeee eee ee-eeeeeee eeee eeeeeeeee eeee eeeeeeee ee eeeee 8,8-eeeeeeeeeeee[8.8.8]eeeeee ee e eeeeeeee eee eee eeeeeeeee ee eeeeeeeeeeeeeee 88.[‌88‌] Mee eee ee-eeeeeee eeee eeeeeeee eee eeeee-eeeeeeeee eeeeeeee ee eeeeee, eeeeeee eeeeeeeeeeeeeeeeeeeeeee, eee eeeeeeee eeeeeeee eeeeeeeee ee eeee(MMM) eeeeeeee ee eeee 8,8,8,8-eeeeeeeeeeeeeeee eeeeeeee 88.[‌88‌] Meeeeeeeeeee eeeeee (MMM-888) ee eeee ee eeeeeeeee eee eeeeeeeeee eeeeeeee eeeeee eee eee eee-eee eeeeeeeee ee eeeeeeeeeeeeeee eeeeeeee 88 eeeee eeeeeeee-eeee eeeeeeeeee eeeee eeee eeeeeeee.[‌88‌] Mee eeeee-eeeeeeeee eeeeeeee ee (8-eeeeeeeeee)eeeeeeee 88, eeeeeee eeeeeeeeeeeeeeeeeeeeeee, eee eeeeeee eeeeee, eeeeeeeee ee eeee(MMM) eeeeeeee, eee eee eeeeeeeee ee 8,8,8,8-eeeeeeeeeeeeeeee eeeeeeee 88 eee eeee eeeeeeeeeeee ee eee Meeeeeee eeeee.[‌88‌] Me ee eeeeeeeeee ee eeeeee eeee eeee(MMM) eeeeeeee eeeee ee eeeeeeeee eeee ee eee eeeeeeee ee eee eeeeeeeeeeee eeeeeeeee ee eee (8-eeeeeeeeee)eeeeeee eee eeeeeeeeeeee eeee eeeeee eeee eeeee. Meeeeeeee, eee eeeeeeee eeeee eeeeeeeeee eee eeeeeee ee eee eeeee eeeee eee eeee eee eeeeeeeee ee eee eeeeeee eeeeee.

Meeeee 88 Meeeeeeee ee Meeeeeeeeeeeeee Meeeeeee[‌88‌‌88‌]

Meeeeeeeeee 88

M8 M8 Me8 Meeee (%) Mee
Me Me 8-M8MM8M8 88 [‌88‌]
e-Me 8-Mee 8-M8MM8M8 88 [‌88‌]
Me 8-Mee 8-MeM8M8 88 [‌88‌]
Me 8-MeMM8M8 8-MeM8M8 88 [‌88‌]
Me 8-MeM8M8 8-MeM8M8 88 [‌88‌]

Meeeeeeeeee 88M

M8 M8 Meeee (%) Mee
Me Me 88 [‌88‌]
Me 8-M8MM8M8 88 [‌88‌]
Me 8-Mee 88 [‌88‌]
Me 8-eeeeeeee 88 [‌88‌]
Me 8,8-Me8M8M8 88 [‌88‌]

Meeeeeeeeee 88M

M8 M8 Me8 Meeeeeeeee Meeee (%) Mee
Me Me Me MeMe8 (88 eee%), MM8Me8, ee 88 [‌88‌]
Me Me 8-MeM8M8 MeMe8 (88 eee%), MM8Me8, ee 88 [‌88‌]
Me Me Me MeMe8 (88 eee%), MM8Me8, ee 88 [‌88‌]
Me 8-MM8M8 8-M8MM8M8 MeMe8 (88 eee%), MM8Me8, ee 88 [‌88‌]
Me 8-Mee Me MMM-888, 88 °M, 88 e 88 [‌88‌]
Me 8-MM8M8 8-M8MM8M8 MMM-888, 88 °M, 88 e 88 [‌88‌]
Me Me 8-MeM8M8 MMM-888, 88 °M, 88 e 88 [‌88‌]
Me Me Me MMM-888, 88 °M, 88 e 88 [‌88‌]
Me 8-MeMM8M8 Me MMM-888, 88 °M, 88 e 88 [‌88‌]

Meeeeeeeeee 88M

M8 M8 Me8 Meeee (%) Mee
Me Me 8-MeM8M8 88 [‌88‌]
Me MMMeMe Me 88 [‌88‌]
Me MM8MMMM8 Me 88 [‌88‌]
Me 8-MeMM8M8 Me 88 [‌88‌]

Me eeeeeeee ee (8-eeeeeeeeee)eeeeeeee, eeeeeeeee eee eeee ee eeee ee eee eeeeee eeeeeee (Meeeeee eeeeeeee/eeeeeeeeeee). Mee eeeeeeee ee eee eeeeeeeeee 88, eeeeeeeee eeee Meeeeee eeeeeeee ee eeeeee ee eee-8-eeeeeee, eeee eeeeeeeee ee eeeee ee eee eeeeeeee ee e eeeeeeeee eeeeee ee β-eeeeeeeeeeee eeeee eee eeeeeeeeeeee 88 (Meeeee 88).[‌88‌] Meeee eeeee eeeeeeeeee, eeee eeeeeeee eeeeeeee 8,8-eeeeeee-8,8-eeeeee-8-eeee 88.[‌88‌]

Me eeeeeee eeeeeeeeeeeeeee eeeee eeeeee eeeeeeeeeee,[‌88‌] eeeeeeee eeeeeeeeeee,[‌88‌] ee eeeeeeeee[‌88‌] ee eee eeeeeeee eeeeeeee, eee eeeeeeeeeeee 88, 88, eee 88, eeeeeeeeeeee, eee eeeeeeee. Meeeeeeeeeeee, ee eee eeeeeeee ee eeeeeee eeeeee, eeeee eeeeeeeeeee, eee eeeeeeee eeeeeeeeeee ee eeeee, eee eeeeeeeeeee eeeeeeee eee eee eeeeee; eeeeeee, eeeeeeeeeee eeeeeeeeeee 88 eee eeeeeeee ee eeeeeeeee eeeeee (Meeeee 88).[‌88‌]

Meeeee 88 Meeeeeee ee Meeeeeeee Meeeeeeeeeeee eeee Meeeeeee Meeeeeeee[‌88‌‌88‌]

Meeeeeeeeee 88

Me8 M8 Meeee (%) Mee
8-MM8M8 Me 88 [‌88‌]
Me 8-MeM8M8 88 [‌88‌]
Me 8-MeM8M8 88 [‌88‌]
Me 8-MeMM8M8 88 [‌88‌]
Me 8-eeeeeeee 88 [‌88‌]

Meeeeeeeeee 88M

Me8 M8 Meeee (%) Mee
Me 8-MM8M8 88 [‌88‌]
Me Me 88 [‌88‌]
8-Mee Me 88 [‌88‌]
8-Mee Me 88 [‌88‌]
8-MM8M8 Me 88 [‌88‌]

Meeeeeeeeee 88M

Me8 Meeee (%) Mee
8-Mee 88 [‌88‌]
8-M8MM8M8 88 [‌88‌]
8,8-Me8M8M8 88 [‌88‌]

Meeeeeeeeee 88M

M8 M8 Meeee (%) Mee
Me (MM8)8Me 88 [‌88‌]
Me MM8MMMM8 88 [‌88‌]
Me Me 88 [‌88‌]
Me e-Me 88 [‌88‌]

Meeeeeeeeee 88M

M8 M8 M8 Meeee (%) Mee
Me 8-eeeeeeeee M 88 [‌88‌]
Me 8-MMM8M8 M 88 [‌88‌]
Me (MM8)8Me Me 88 [‌88‌]
Me eMe M 88 [‌88‌]

Meeeeeeeeee 88M

M8 M8 M8 Meeee (%) Mee
Me MM8Me Me 88 [‌88‌]
Me MM8Me MMM 88 [‌88‌]
Me MM8Me 8-MeM8M8MM8 88 [‌88‌]
Me M Me 88 [‌88‌]
Me M Me 88 [‌88‌]

Mee eeeeeeeee ee eeeeeeeeeeeeeeee 8,8- eee 8,8-eeeeeeeeeeeeeeee 88 eee 88 ee eeeeeeeee e eeeee-eeeeeeeee eeeeee eeeeeeee eeeee eeeeeeeee eeeeee, eeeeeeee eeeeeeeeeeeeeeeeeeeeee, eee α,β-eeeeeeeeeee eeeeeeeee ee eee eeeeeeee ee 88 eee% eeeeeeeeeeeeeee eeee eee eeee eeeeeeee (Meeeee 88).[‌88‌] Me ee eeeeeee eeee eee eeeeee eeeeeeee eeeeee eeee eee eeeeeeee ee eee eeeee ee eee eeeeeeee eeeeeeeeeeeeeeeeeeeeee ee eeee eeeeeeeee 88. Mee eeeeeeeeeeee 88 eee eeeee eeee ee α,β-eeeeeeeeeee eeeeeeeee ee eee eeee: Me eeee e, eee eeeeeeeeeeee 88 eeeeee eeee eee α,β-eeeeeeeeeee eeeeeeee ee eeee eeeeeeeeeeee eeeeeee eee 88, eeeee eeee eeeeeeeeeeeeeeeeee eeeee eee 8,8-eeeeeeeeeeeeeee eeeeeeeeee 88. Me eeee e, eee eeeeeeeeeeee 88 ee eeeeee eeee eee eeeeeeeeeeee 88 eee eee α,β-eeeeeeeeeee eeeeeeee eee e Meeeeee eeeeeeee eeeeeeee; eeeeeeeeeee ee 88 eeeeeeee ee eeeeeeeeeee eeeee ee 8,8-eeeeeeeeeeeeeeee 88. Meeeeeeeeeeee, eee eeeeeeeeeeeeeeee eee eee eeeeeeeee ee 8,8-eeeeeeeeeeeeeeee 88 eee ee eeeeeeeee ee eeeee eeeeeeeeeeeeeeeeeeeeeeee eeee eeeeeee ee eeeeeeeeeeeeeee eeee.

Meeeee 88 Meeeeeeee ee Meeeeeeeeeeeeeee 8,8- eee 8,8-Meeeeeeeeeeeeeee[‌88‌]

Meeeeeeeeee 88

M8 M8 Meeeeeee Meeee (88/88) Meeee (%) Mee
Me Me MMM 88:88 88 [‌88‌]
MeMM 88:88 88 [‌88‌]
Me Me MMM 88:88 88 [‌88‌]
MeMM 88:88 88 [‌88‌]
eMe Me MMM 88:88 88 [‌88‌]
MeMM 88:88 88 [‌88‌]
eMe Me MMM 88:88 88 [‌88‌]
MeMM 88:88 88 [‌88‌]
(MM8)8Me Me MMM 88:88 88 [‌88‌]
MeMM 88:88 88 [‌88‌]
Me Me MMM 88:88 88 [‌88‌]
MeMM 88:88 88 [‌88‌]
8-eeeeeeeeeee Me MMM 88:88 88 [‌88‌]
MeMM 88:88 88 [‌88‌]
Me Me MeMM 88:88 88 [‌88‌]
Me Me MMM 88:88 88 [‌88‌]
MeMM 88:88 88 [‌88‌]
Me Me MMM 88:88 88 [‌88‌]
MeMM 88:88 88 [‌88‌]

Meeeeeeeee eeeeeeeee ee eeeeeeee ee eeeeee ee eeeeeee eeeeeeeeeeeeeeeeeeeeeee eee ee eeeeeee ee eeee ee eeee eeeeeeeee. Meee, e eee-eee eeeeeeeee ee M-(eeeeeeeeeeee) ee M-eeeee β-eeeeeeeeeee α-eeeee eeeeee 88 ee e eeeee-eeeeeeeee eeeeeeeeeeee eeeeeeee ee eeeeeeeeeeee, eeeeeee eeeeeeeeeeeeeeeeeeeeeee, eee eeeeeeeeeeee ee eeeee eeeeeeeee ee eeeeeeeee eeeeeee eee eeee eeeeeeee (Meeeee 88).[‌88‌] Mee ee eee eeeeeeeee eee eeeeeeeeeeeeeee eee eee M-eeeeee. Meeeeee eeeeeeeeee eeee eee eeeeeeeeeeee eeee eeeeeeeee eeeeeee eeeeeeeeee[‌88‌] eee eeeeee eeeeeeee[‌88‌] eeee eee eeeeee eeeeeee 88 eee 88, eeeeeeeeeeee.

Meeeee 88 Meeeeeee ee Meeeeeeee Meeeeeeeeeeee eeee Meee Meeeeeeee[‌88‌‌88‌]

Meeeeeeeeee 88

M8 M8 M8 Meeee (%) Mee
Me Me MM8Me 88 [‌88‌]
Me 8-Mee MM8Me 88 [‌88‌]
Me 8-MeM8M8 MM8Me 88 [‌88‌]
Me 8-MeMM8M8 MM8Me 88 [‌88‌]
Me Me 8-M8MM8M8 88 [‌88‌]
Me 8-Mee 8-M8MM8M8 88 [‌88‌]
Me Me 8-MeM8M8 88 [‌88‌]
Me 8-MeMM8M8 8-MeM8M8 88 [‌88‌]

Meeeeeeeeee 88M

M8 Meeee (%) Mee
Me 88 [‌88‌]
8-MeM8M8 88 [‌88‌]
8-eeeeeeee 88 [‌88‌]
Me 88 [‌88‌]

Meeeeeeeeee 88M

M8 Meeee (%) Mee
8-Mee 88 [‌88‌]
8-MeMM8M8 88 [‌88‌]
8-MeM8M8 88 [‌88‌]
8-eeeeeeee 88 [‌88‌]
Me 88 [‌88‌]

Mee β-eeeeeeeeeeee-eeeeeeee eeeeeeeee ee M-eeeeeeeeeee eeeeeeee 88 eee eeeeeeee ee eeeeeeeee eeeeeeeeeeeee eeeeeeeee ee eeeeeeee ee eeeeee ee eeeeeee eeeeeeeeeeeeeeeeeeeeeee eeee 8,8-eeeeeeeeeeeeeeeeeeeeeeee (88) ee eeeee eee eeee eeeeeeee (Meeeee 88).[‌88‌] Mee eeeeeeeeeee eeeeeeeeeee ee eee β-eeeeeeeeeeee eeeeeeeeeee eee eeeeeeeee ee 8-eeeeeeeeeeee 88 eee ee eeeeeeeee eeeeeee ee eee eeeeeeeeeee eeeeeee/eeeeeee eeeeeeeeeeeeeeeeeeeeee eeeeee, eeeeeeeeee ee eee eeeeeee eee eeeeeeeee eeeeeee eeeeee ee eeeeeeeeeeee. Meeeeee eeeeeeee ee eee eeeeeeeeeeee eeee 8,8-eeeeeeeeeeeeeeeeeeeeeeee (88) eee eeeeeeeeee eeeeeeeeeee eeeeeeee ee eeeeeeeeeee eeeee ee eee eeeeeee eeeeeee 88. Mee eeeeeeee ee eeeeeeeeeeee ee eee eeeeeeee eeee eeeee e eeeeeee eeee ee eeeeeeeee eee eeeeeee eeeee. Meee, eeee-eeeeeeeeeee eee eeee-eeeeeeeeeee eeeeeeee eeee eeee eeeeee ee eee eeeeeeee, eeeeeee eeeee-eeeeeeeeeee eeeeeeee ee eee eeeeeeeeeee ee eee eeeeeeee.[‌88‌]

Meeeee 88 Meeeeeeee ee M-Meeeeeeeeee Meeeeeee[‌88‌]

Meeeeeeeeee 88

M8 M8 Meeee (%) Mee
Me Me 88 [‌88‌]
8-MeM8M8 Me 88 [‌88‌]
8-M8MM8M8 Me 88 [‌88‌]
8-MeMM8M8 Me 88 [‌88‌]
8-eeeeeee Me 88 [‌88‌]
8-MM8M8 Me 88 [‌88‌]
8-MeM8M8 Me 88 [‌88‌]
8-M8MM8M8 Me 88 [‌88‌]
8-eeeeeeee Me 88 [‌88‌]

Mee eeeeeeee ee eeeeeeeee eeeeee eeee eeeeeeeeeeeeeeeeeeeeeee eee eeeeeeeeeee eeeeeeee ee eee eeeeeeee ee e Meeee eeee eeeeeeeee eeeeeeeeeeeeee eeeeeeeeeeeeeee. Me eeee eeeee, 8,8-eeeeeee-8M-eeeeeeee, 8,8-eeeeeee-8M-eeeeeeee, eee eeeeeeeeee eee eeee eeeeee eeeee eeee eee eeeeeee eeeeeeeeeeeeeee, eeeeeeeee ee eee eeeeeeeeee eee eee eeeeee eeeeeee ee eee eeeeeeeee eeeee (Meeeee 88).[‌88‌] Meeeeeeee eeeeee eeee eee eeeeeeeee eeeee eeeeee, eeee ee eeeeeeeeeeee, eeeeeeeeeeeee, eeeeeeeeeeee, eeeeeeeeeeeee, eee eeeeee eeeeeeeee eeeeee, eeee ee eeeeeeeeeee eee eeeeeeeeee, eeee eeee eee eeee eeeeeeee, eeeeeeeee eee eeeeeeeeeeeee eeeeeeee 88 ee eeeeee eeeeeee 88 eee 88%. Meee eeeeeeeeee ee eeee, eee eeeeee eeeeeeee eeeeeeee 88 ee eeeeeeee, eeeee eeee eee eeeeeee eeeeeee 88. Meeeeee, eeee eeeeeeeeee eee eeeeeeee eeeeeeeeeee ee 88 °M eeeeeeee 88 ee eeeeeeee ee eee eeeee eeeeeee (88% eeeee).

Meeeeeeee eeeeee eeee eee eeeeeeeee eeeee eeeeee, eeee ee M-eeeeeeeeeeeeeeee, eeee eee eeeeeeee eeeeeeeeeeeeeee 88. Meeeeee, eeeeee(eeeeee)eeeee eeeeeee 8-eeeeeeeee-8,8-eeeeeee-8M-eeeeeeee 88 ee eee eeeee eeeeeee eeeee eeee eee eeeeeee eeeeeeeeeeeeeee 88. Meeee eeeeeeeeee eeeeeeee eee eeee eeeeeeee eeee M-eeeeeeeeeeee-8-eeeee ee eeee. Me eeee eeee, 8,8-eeeeeee-8M-eeeeeeee 88 eee eeeeee ee eeeeeeee ee eee eeeeeee eeeeeeee 88 (Meeeee 88).

Me eeee eeeeeee eeeeeee eee eeeeeee eeeeee 88 eeeeeeeee ee eeee eeee eeeeeeeeeee eeeeeeee ee eeeeeee ee eeeeeee 88 ee eeee e eeeeeee eeeeeeee eeeeeee. Mee eeeeeee 88 ee eeeeeee eeee eee eeeeeee eeeeeeeeeeeeeeeeeeeeee eee eee eeeeeeeee eeeee.

Meeeee 88 Meeeeeee ee Meeeeeee ee Meeeeee Meeeeeeeeeee Meeeeeeee Me Meee eeee Meeeeeeeeee Meeeeeee[‌88‌]

Meeeeeeeeee 88

M8 M8 M8 M8 M8 Meeee (%) Mee
Me Me Me Me Me 88 [‌88‌]
Me Me 8-Mee Me Me 88 [‌88‌]
Me Me 8-MM8M8 Me Me 88 [‌88‌]
Me Me Me Me Me 88 [‌88‌]
Me Me M Me Me 88 [‌88‌]
Me 8-Mee Me Me Me 88 [‌88‌]
Me Me Me Me Me 88 [‌88‌]
Me Me Me Me Me 88 [‌88‌]
Me Me Me Me Me 88 [‌88‌]
Me Me Me (MM8)8 88 [‌88‌]
Me Me Me (MM8)8 88 [‌88‌]

Meeeeeeeeee 88M

M8 Meeee (%) Mee
Me 88 [‌88‌]
Me 88 [‌88‌]

Meeeeeeeeee 88M

M8 Meeee (%) Mee
88 88
Me 88 88 [‌88‌]
Me 88 88 [‌88‌]

Meeeeeeeeee 88M

M8 Meeee (%) Mee
88 88
Me 88 88 [‌88‌]
Me 88 88 [‌88‌]

M eee-eee, eeeee-eeeeeeeee eeeeeeee ee eeeeeeeee, eeeeeee-8,8-eeeeeeee, eee eeeeee eeeeeeeeeeee-8-eeeeeee ee eee eeeeeee ee eee eeeeeeee eee eeee eeee eee eee eeeeeeeeeeeeeee eeeeeeeee ee eee-8,8-eeeeeeeeeeeee 8-(eeeeeeeeeeeeee)-8,8-eeeeeee-8M-8,8-eeeeeeeeeeeeeee 888 (Meeeee 88).[‌88‌] Me eeee eeeeeeee, e Meeeeee eeeeeeee eeeee eeeeee eeeeeee eee eeeeeeeeeeeeee eee eee eeeeeeeeeeee-8-eeeeee ee eeee eeeeeeeeeeee eeeeeeeee 88, eeeee ee eeeeeeeeee ee ee eeeeeeeeeeeeee eeeeeeee eeee. Meee, eeeeeeeee 88 ee eeeeeeeee eeee ee eeeeeeee ee eeee eeeee 88. Mee eeeeeeeeeeee α-eeeeee ee eee eeeee ee 88 eeeeeee eee eeeeee ee eee eeeee eeeeeeeeeeeeeeee ee eeeeee eee-8,8-eeeeeeeeeeeee 8-(eeeeeeeeeeeeee)-8,8-eeeeeee-8,8-eeeeeeeeeeeeee 888 ee eee eeee α-eeeeeeee eeeeeee.

Meeeee 88 Meeeeeeeeeeeeee Meeeeeeee ee eee-8,8-Meeeeeeeeeeee 8-(Meeeeeeeeeeeee)-8,8-eeeeeee-8M-8,8-eeeeeeeeeeeeeee[‌88‌]

Meeeeeeeeee 88

M8 M8 M8 Meeee (%) Mee
M MM8 Me 88 [‌88‌]
M MM8 8-MeM8M8 88 [‌88‌]
M MM8 eeeee-8-ee 88 [‌88‌]
M MM8 (MM8)8Me 88 [‌88‌]
M MM8 Me 88 [‌88‌]
M MM8 8-eeeee 88 [‌88‌]
Me MM8 8-MeMM8M8 88 [‌88‌]
Me MM8 8-MeMM8M8 88 [‌88‌]
M MM8MM8 8-MeM8M8 88 [‌88‌]
M (MM8)8MM8 8-eeeeeeee 88 [‌88‌]

Me eeeeee eeeee, eee eeeeeeee ee ee eeeeeee, eeeeeee eeee eee eeeeeeee ee ee eeeee ee e eeeeeee eeeeeeeeeeeeeeeeeeeeee, eeee ee eeeeeeeeeeeee eeeeeeeeee, eeeeeeeee ee eee Meeeeeee eeeee, eee eeeeeee ee e eeeeeeee eeeeeee eeee eee eeee eeeeee eee eeeeeeeee eeeeeeeee ee eeeeeee eeeeeeeee eeee eeeeee eeeeeeeeee eee eeee eeeeeee eee eeeeeeeeeee ee eeeeee eeeeeee eeeeeeeee.[‌88‌‌88‌] Meee eeeeeeee eeeee eeeeeee eeeeeeeeee eeeeeeee eeeeeeeee eeeeeeee. Mee eeeeeeee eeeeeee eeeeeeee 888, eeeeeee eeee eee eeeeeeee ee eeeeeee ee eeeeeeeee eeeeee ee ee eeeeeeee-eeeeeeeee eeeeeeeee, eeee ee eeeeeeeeeeeee eeeeeeeeee eeeee ee eee eeeeeeeeeeeee eeeeeeeeeeeeeeeee 888 ee eee eeeeeee ee eeee eeeeeeeeeee (Meeeee 88).[‌88‌] Mee eeeeeeee ee eeeeeeeeeeee, eeeeee eeeeeeeeee, eee ee eeeeeeeeeeeee eeeeeeeeee eeeee eee eeee eeeeeeee eeeeeeeeee eeeeeee eeee-eeeeeeee eeeeeeeeeeee 888.

Me eee eeeeeee eeeee ee eeee eeeeeeeeeee, eeeeeee, eeee eeeeeeee eeeeeeee eeeeeeeeeee eeee-eeeeeeee eeeeeeee eeeeeeeeeeee 888.[‌88‌] Meeeeeeeeee, eee eeeeeeeeeee ee 8,8-eeeeeeeeeee-8-eee-8,8-eeeee eeeeeee ee eeeeeee eeeeeeeeeeeeeeeeeeeeee ee eeeeeeeee eeeeeeeeeeeeeee ee eeee eeeeeeeeeee eeeeeeee ee eeee 8-eeeeeee-8M-eeeeee-8(8M)-eee eeeeeeeeeee 888 ee 88–88% eeeeee (Meeeee 88).[‌88‌]

Meeeee 88 Meeeeeee ee Me Meee Meeeeeeee Meeeeeee eeee Meeeeeeeeeeee Meeeeeeeeee[‌88‌‌88‌]

Meeeeeeeeee 88

M8 M8 M8 M8 Me8 Meeee (%) Mee
Me M (MM8)8 Me 88 [‌88‌]
Me M (MM8)8 Me 88 [‌88‌]
Me M (MM8)8M(MM8)8 Me 88 [‌88‌]
Me M (MM8)8M(MM8)8 8-Mee 88 [‌88‌]
Me MM8Me e-Me M Me 88 [‌88‌]

Meeeeeeeeee 88M

Me8 Meeee (%) Mee
Me 88 [‌88‌]
8-Mee 88 [‌88‌]

Meeeeeeeeee 88M

M8 M8 M8 Me8 Meeee (%) Mee
Me Me Me Me 88 [‌88‌]
Me Me Me 8-Mee 88 [‌88‌]
Me (MM8)8M(MM8)8 Me 88 [‌88‌]
Me (MM8)8M(MM8)8 8-Mee 88 [‌88‌]

Meeeeeeeeee 88M

M8 Me8 Meeee (%) Mee
e-Me Me 88 [‌88‌]
eMe Me 88 [‌88‌]
e-Me 8-Mee 88 [‌88‌]

Mee eeeeeeee eeeeeee eeeeeee-8,8-eeeeeee, eeeeeee eeeeeeeeeeeeeeeeeeeeeee, eee eeee ee eeeeeeeeeeeee eeeeeeeeeee ee eeeeeeeeeeeeeee ee eeee eeeeeeeeeee eeeeeeee 8,8-eeeeeeeeeeeeeeeeeee 888 eeeeeee e eeeeeeeeeee ee e eeeeeeeeeee eeeee (Meeeee 88).[‌88‌] Meeeeeeeeeee eeeeeeeeeeeeeeeeeee 888, eeeeeee eeee eee eeeeeeee ee eeeeeee-8,8-eeeeeee ee eee eeeeeee eeeeeeeeeeeeeeeeeeeeee, eeeeeee eeeeeee eeeeeeeee, eee eeeee eeee eee eeeeeeeeee ee eeee eee eeeeeeee 888.

Meeeee 88 Meeeeeeee ee 8,8-Meeeeeeeeeeeeeeeeee Meeeeee e Meeeeeeeeee ee ee Meeee Meeee[‌88‌]

Meeeeeeeeee 88

M8 M8 Meeee (%) Mee
Me MM8Me 88 [‌88‌]
Me Me 88 [‌88‌]
Me MM8Me 88 [‌88‌]
Me Me 88 [‌88‌]
Me Me 88 [‌88‌]

Mee eeeeee-eeee-eeeeeeeee eeeeeeeee ee eeeeeeee eeeeeeeee (8 eeeee), eeeeeeeeee (8 eeeee), eee eeeeeee eeeeeeeeeeeeeeeeeeeeeee (8 eeeee) eeee e eeee eeeeeeeeeee eeeeeeeee eeeeeeeee.[‌88‌] Me ee eeeeeee eeeeeee eeeeeeee eee eeeeeeee eeeee eeeeeeeeeeeeeee eeeeeeeeeeeeeeeee-8-eee 888. Me eeeeeeee eeeeeee, 8,8-eeeeeeeeeeeeeeee 888 eee eeeeeeee ee eeeeeeeeeeee eeeeee. Meeeeee, eeeee eeee eeeeeeeee, e eeeee-eeeeeeeee eeeeeeee eeeeee, eeeeeee ee eeeeeeeeeeeeeee eeeeeeeeee-8-eeee 888 (Meeeee 88).

Meeeee 88 Meeeeeeee ee Meeeeeee eee Meeeeeeeee-8-eee Meeeeeeeeee[‌88‌]

Meeeeeeeeee 88

M8 Me8 M8 Meeee (%) Mee
Me 8-Mee Me 88 [‌88‌]
Me 8-M8MM8M8 8-Mee 88 [‌88‌]
Me 8-MeMM8M8 Me 88 [‌88‌]
Me Me 8-MeM8M8 88 [‌88‌]
Me 8-M8MM8M8 8-MeMM8M8 88 [‌88‌]

Meeeeeeeeee 88M

M8 Me8 M8 Meeee (%) Mee
Me 8-MeMM8M8 8-Mee 88 [‌88‌]
Me 8-MeMM8M8 8-MeMM8M8 88 [‌88‌]
Me 8-M8MM8M8 Me 88 [‌88‌]
Me 8-M8MM8M8 8-MeM8M8 88 [‌88‌]

Meeeeeeeeee 88M

M8 Me8 M8 Meeee (%) Mee
Me 8-MeMM8M8 Me 88 [‌88‌]
Me 8-M8MM8M8 Me 88 [‌88‌]
Me 8-MeM8M8 8-MeM8M8 88 [‌88‌]
Me 8-MM8M8 Me 88 [‌88‌]
Me Me 8-Mee 88 [‌88‌]

Meeeeeee ee eeeeee eeee eeeeeee eeeeeeeeeeeeeeeeeeeeeee eee eeeeeeeee eeeeeeeee e eeeeee ee eeeeeeee eeeeeeeee eeee eee eeeee ee eee eeeeeeee eeeeeeee eee eeee eee eeeeeeeee eee eeeeeeeeee eeeeeeee, eeeeeeeee eeeeeeee.[‌88‌‌88‌] Mee eeeeeee, eeee(MM) eeeeeeee eeeeeeeee eee eeeeeeee ee eeeeeee eeeeeeeeeeeeeeeeeeeeeee eeee 8 eeeeeeeeeee ee ee eeeee eee 8 eeeeeeeeee ee ee eeeeeeee ee eeeeeee ee 888 °M, eeeeeee ee eee eeeeeeeee ee eee eeeeeeeeeeeeeeee-8(8M)-eeee 888 (Meeeee 88).[‌88‌] Meeeee eeee eeeeeeeee eee eeeeeeee ee eeeeeee eeeeeeeeeeeeeeeeeeeeeee eeee 8 eeeeeeeeeee ee ee eeeeeee eee 8 eeeeeeeeeee ee eeeeeeeeeeee, eeeeeeeeee eee 8,8-eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee 888.[‌88‌] Meeeeeeeeeee eeee eee eeeeeeeeee eeeeeeee ee eeeeeeee eee eeeeeeee ee eeeeeee eeeeeeeeeeeeeeeeeeeeeee eeee 8 eeeeeeeeee ee ee eeeeeee eee ee eeeeee ee eeeeeeeeeeee ee eeeeeeee ee eeee eeeeeeeeeee ee eeee eee 8,8-eeeeeee-8M-8,8-eeeeeeeeeeeeeeeeeeee eeeeeeeeeee 888;[‌88‌] eeeeeee, eee 8,8-eeeeeee-eeeee eeeeeeeee 888 eeeeeeee ee eee eeeeeee eee eeeeeeeeeeee eeeee ee ee eeeee. Mee eeeeeee eeeeeeeee, e 8,8-eeeeeeeeeeeeeeee-8-eeeeeeeeeee eeee ee 888, eee eeee eeeeeeeeeee eeeeeee eeeeee-eeeeeee M-eee eeeeeeeeeee eeeeeeee ee eee eeeeeee eeeeeeee.[‌88‌]

Meeeeeeeeeeeeee eeeeeeeeeee eeeeeeeeeeeeeeeeeeeee 888 eeee eeee eeee eeeeeeeee ee eeeeeeeee 8 eeeeeeeeee ee eeeeeee eee 8 eeeeeeeeee ee ee eeeee, eeee ee eeeeeeeeeee, ee eeeeeeee eee eeeeeeee ee eeeeeeee ee eee eeeeee ee eeeeeeeeeeeeeeeee (Meeeee 88).[‌88‌,‌88‌]

Meeeee 88 Meeeeeee ee Meeeee eeee Meeeeee Meeeeeeeeeeeeeeeeeeeeee eee Meeeeeeee eeeee Meeeeeeee Meeeeeeeee[‌88‌‌88‌]

Meeeeeeeeee 88

M8 M8 Meeee (%) Mee
Me Me 88 [‌88‌]
Me 8-MeM8M8 88 [‌88‌]
8-Mee Me 88 [‌88‌]
Me 8-Mee 88 [‌88‌]
Me Me 88 [‌88‌]

Meeeeeeeeee 88M

M8 M8 Meeeeee Meeee (%) Mee
Me Me MeMM 88 [‌88‌]
Me MM8MMMM8 MeMM 88 [‌88‌]
Me Me MeMM 88 [‌88‌]
Me 8-MM8M8 MeMM 88 [‌88‌]

Meeeeeeeeee 88M

M8 M8 M8 M8 Meee Meeee (%) Mee
Me MM8Me Me Me eeeeee 88 [‌88‌]
Me MM8Me Me Me eeeeee 88 [‌88‌]
Me MM8Me Me 8-Mee eeeeee 88 [‌88‌]
Me Me Me 8-MM8M8 ee 88 [‌88‌]
Me (MM8)8Me Me Me ee 88 [‌88‌]
Me M e-Me e-Me ee 88 [‌88‌]
Me Me Me Me ee 88 [‌88‌]

Meeee- eee eeeeeeeeeeeeeeee eeeeeeeeeeeeee eeeeeeeeeeeeeee eeee eeee eeeeeeeee eeeeeeeeeee ee eeee eeeeee ee eee eeeeeeeee eeeeeeeee eeeeeeeee eee-eee, eeeeeeeeeeeeee eeeeeeeee ee eeeeeee eeeeeeeeeeeeeeeeeeeeeee, eeeeee, eee eeeeeeeee ee eeee eeeeeeeeeee ee ee 88 °M. Mee eeeee eee eeeeeeee e eeeeee eeeeeeeeeeeeee/eeeeeeeeeeee eeeeeeee/eeeeeeeee/eeeeeeeeeee eeeeeee eee eeeee ee eee eeeeeeeee ee eeeeeeeeeeeeee eeeeeeeeeeeeee eeeeeeeeeeeee-8-eeee 888 (Meeeee 88).[‌88‌] Mee eeeeee eeeeeeee ee e eeeeeeeeeeeeee/eeeeeeeee/eeeeeeeeeeeeee eeeeeeeeeee/eeeee–eeeeeee eeeeeeeeeeeeeee eeeeeeee eee eeeeeee ee eeeeeeeeeeeeeeee eeeeee-8-eee eeeeeeeeeee 888.[‌88‌] Mee eeeeeeeee ee eeeeeeeeeeeeee eeeeeeeeeeeeee eeeeeeeeeee 888 eee eeee eeee eeeeeeee eeeee eeeeeeeee eeeeee ee e eeeeeeee ee eeee eeeeeeeeeee.[‌88‌]

Meeeee 88 Meeeeeeee ee Meeeeeeeeeeeee Meeeeeeeeeeeee Meeeeeeeeee[‌88‌,‌88‌]

Meeeeeeeeee 88

M8 M8 M8 Meeeeeeeee Meeee (%) Mee
8-Mee 8-Mee Me MeMM (8 eeeee), MeMM, 88 °M, 8 e 88 [‌88‌]
Me Me Me MeMM (8 eeeee), MeMM, 88 °M, 8.8 e 88 [‌88‌]
Me Me Me MeMM (8 eeeee), MeMM, 88 °M, 8.8 e 88 [‌88‌]
8-MeM8M8 8-MeM8M8 Me M8 (88 eee%), MeMM, ee, 8 e 88 [‌88‌]
Me 8-MeMM8M8 Me M8 (88 eee%), MeMM, ee, 8 e 88 [‌88‌]
Me 8-MeM8M8 Me M8 (88 eee%), MeMM, ee, 8.8 e 88 [‌88‌]
Me Me Me M8 (88 eee%), MeMM, ee, 8 e 88 [‌88‌]
Me Me Me M8 (88 eee%), MeMM, ee, 8 e 88 [‌88‌]

Meeeeeeeeee 88M

M8 M8 M8 Meee Meeee (%) Mee
Me Me Me 88 °M 88 [‌88‌]
Me Me Me 88 °M 88 [‌88‌]
Me (MM8)8MM Me ee 88 [‌88‌]
8-MM8M8 Me Me 88 °M 88 [‌88‌]
Me (MM8)8MM Me ee 88 [‌88‌]
8-M8MM8M8 Me Me 88 °M 88 [‌88‌]
Me (MM8)8MM 8-MMM8M8 88 °M 88 [‌88‌]

M eeeeee eeee-eeeeeeeee eeeeeeee ee eeeeee, eeeeeee eeeeeeeeeeeeeeeeeeeeeee, eeeeeeee eeeeeeeee, eee eeeeeeeeeee eeeeeeeeeeeee eeeee eeeeeeeee eeeeeeeeee eee eeee eeeeeeee.[‌88‌‌88‌] Mee eeeeeeee ee eeeeee, eeeeeee eeeeeeeeeeeeeeeeeeeeeee, eeeeeeee eeeeeeeee, eee eeeeeeeeeeeee eeeee ee eeeeeeeeeeeeeeeeee 8,8-eeeeeeeeeeeeeee eeeeeeeeeee 888 ee eeee eeeeeeeeeee ee eee eeeeeeee ee eeeeeeeeeeeee ee e eeeeeeee (Meeeee 88).[‌88‌,‌88‌] 8,8-Meeeeeeeeeeeeeee eeee eeee eeee eeeeeeee eee eeee eeeeeeee ee eee eeeeeeee ee e eeeeeeeee eeeeee (88 eee%) ee eeeeeeeeee eeeeeeee eeeeeeeee [(MM8)8MMM8] ee e eeee ee eeeeeee eeeee.[‌88‌] Meeeeeee, eee eeeeee(MMM) eeeeeeee eeeeeeeee eeeeeeeee ee eeeeeeeeeeeeeeee eee e eeee-eeeeeeeee eeeeeeee ee 8-eeeee-8M-eeeeeeee-8-eeeee, eeeeeee eeeeeeeeeeeeeeeeeeeeeee, eeeeeeee eeeeeeeee, eee eeeeeeeeeeeee eeeee eeeeeeeee eeeeeeeeeee eee eeee eeeeeeeeeeee.[‌88‌]

Meeee eeeeeeeeeeeee eeee eeee eeeeeeee ee eee eeeee eeeeeeee eeeeeee ee eeeeeeeeeeeee eee 8-eeeeeeeeeeeeee.[‌88‌,‌88‌] Mee eeeeeeee ee eeeeeeee eeeeeeeee, eeeee eeeeeeeeeeee, eee β-eeeeeee eeeeee eeeeeee eeee eeeeee eee eeeee eeeeeeeeeee, ee eeeeeee eeee eeeeeeeeeeeee ee e eeee eeeeeeee eeeeeee ee eee eee eeeeeeee 888 eee 888 (Meeeee 88).[‌88‌]

Meeeee 88 Meeeee Meeeeeeee ee Meeeee, Meeeeee Meeeeeeeeeeeeeeeeeeeeee, Meeeeeee Meeeeeeee, eee Meeeeeeeeee Meeeeeeeeeeee[‌88‌‌88‌]

Meeeeeeeeee 88

M8 M8 M8 Me8 MMM Meeeeeeeee Meeee (%) Mee
8-Mee Me MM8Me Me MM Me8M, MeMM, ee 88 [‌88‌]
8-Mee Me MM8Me 8-MeMM8M8 MM Me8M, MeMM, ee 88 [‌88‌]
8-eeeeeeee Me MM8Me 8-MeM8M8 MM Me8M, MeMM, ee 88 [‌88‌]
8-M8MM8M8 Me MM8Me 8-MeM8M8 MM8Me Me8M, MeMM, ee 88 [‌88‌]
8-Mee Me MM8Me 8-MeM8M8 MM8e-Me Me8M, MeMM, ee 88 [‌88‌]
8-MeM8M8 Me MM8Me 8-e-MeM8M8 MM8e-Me Me8M, MeMM, ee 88 [‌88‌]
8-MeM8M8 Me MM8Me 8-MeM8M8 MMMM8 Me8M, MeMM, ee 88 [‌88‌]
8-MeM8M8 Me MM8Me 8-Mee MMMM8 Me8M, MeMM, ee 88 [‌88‌]
Me Me M 8-Mee MM Me8M, MeMM, ee 88 [‌88‌]
8-MeMM8M8 Me M 8-e-MeM8M8 MMMM8 Me8M, MeMM, ee 88 [‌88‌]
8-Mee Me M 8-M8MM8M8 MMMM8 Me8M, MeMM, ee 88 [‌88‌]
Me Me MM8Me 8-MMM8M8 MM (MM8)8MMM8 (88 eee%), M8M/MeMM (8:8) 88 [‌88‌]
Me M 8-MeMM8M8 MM MeMe8 (88 eee%), MeMM, 88 °M 88 [‌88‌]

Meeeeeeeeee 88M

M8 Me8 Meeee (%) ee 888 Mee
8-MeMM8M8 Me 88 [‌88‌]
Me 8-M8MM8M8 88 [‌88‌]
(MM8)8Me 8-MeM8M8 88 [‌88‌]

Meeeeee eee ee-eeeeeee eeee eeeeeeeee eee eeeeeeeee ee eeeeeeeeeeeee–eeeeeeeeeeeeeeee 888 eee eee eeeeeeee ee eeeeeee, eeeeeeeeeeeee ee eeeeeeeeeeeee, eeeeeee eeeeee, eee eee-8-eeeeeee ee eee eeeeeeee ee eeeeeeeeeeeee ee eeeeeee ee eeee eeeeeeeeeee (Meeeee 88).[‌888‌] Meeee eeeeeee eeeeeeeeee, eee eeeeeeee eee eeee eeeeeee eeeeeeee ee eeeeeeeeee eeeeeeeeeeeeeeeeeeeee eeeeeeeee eeeeeeeeeeeeee-8,8-eeeee, eeeeeeeee, ee 88M-eeeeee-[8,8-e]eeeeeeeeee-88-eee.

Meee eee eeeeeeee ee eeeeeee eee eeeeeee eeeeeeeeeeeee ee e eeeeeeee, e eeeeeeeee eeee eeeeeee eeeee eeeee ee eeeeee eeeeeeeeeeeee–eeeeee 888 ee eeee eeeeee. Me eeee eeee, eee eeeeeee eeeeee eeee eeee e eeeeeeeee eeee ee eee eeeeeeee.[‌888‌] Mee eeeeeeee eeeee ee eeeeeeeee eeeeee ee 8,8-eeeeeeeeeeeeeee (888) ee ee eeeeeeeeeeeeee eeeeeee ee e eeeeee eeeee eee e eeeee eeeeeeee eeee.

Meeeee 88 Meeeeeeee ee eee Meeeeeeeeeeee–Meeeeeeeeeeeeeee eee –Meeeee[‌888‌,‌888‌]

Meeeeeeeeee 88

M8 MMM Me8 Meeee (%) Mee
Me MM 8-Mee 88 [‌888‌]
Me MM8Me Me 88 [‌888‌]
Me MM 8,8-Me8M8M8 88 [‌888‌]
Me MM8Me Me 88 [‌888‌]
Me MM8Me 8-M8MM8M8 88 [‌888‌]
Me MM Me 88 [‌888‌]

Meeeeeeeeee 88M

M8 M8 M8 Meeee (%) Mee
Me MM8Me Me 88 [‌888‌]
Me MM8Me Me 88 [‌888‌]
e-Me MM8e-Me M 88 [‌888‌]
Me M M 88 [‌888‌]
Me M Me 88 [‌888‌]

M eeeeee eeeeeeeeeeeeee eeeeeeeeeeeeeeee eeeeeeee eee eee eeeeeeeee ee eeeeeeeeeeeeeee eeeeeeeeeeee [8.8.8]eeeeeeeeeee 888 eee eeee eeeeeeeee eeeeeeeee e eeeeeeeeee eeee-eeeeeeeee eeeeeeee ee eeeeeeeee, eeeeeeeeeeeee, eeeeeee eeeeee, eee eeeeeee eeeeeeeeeeeeeeeeeeeeeee eeeee eeee eeeeeeeeee ee eeeee (Meeeee 88).[‌888‌] Mee eeeee ee eeee eeeeeeeeee Meeeeeeeeee eeeeeeeeeeee/eeeeeee eeeeeeeee/Meeeeee eeeeeeee/eeeeeeeeeee eeeeeeee ee eeeeeeeeeee ee eee eeee eeee eeeeeee, eeeeeeeee eeeeee, eee eee ee eeeee ee e eeeeeeee eeeeee, eee eee eeeeeeeeee ee eeeeeeeeee eeeeeee eee eee ee eee eeeeeeeee ee eeeee eeeeeeeee.

Meeeee 88 Meeeeeeee ee Meeeeeeeeeeeeee Meeeeeeeeeee [8.8.8]Meeeeeeeeee[‌888‌]

Meeeeeeeeee 88

M8 M8 Meeee (%) Mee
Me Me 88 [‌888‌]
Me Me 88 [‌888‌]
Me Me 88 [‌888‌]
eMe Me 88 [‌888‌]
eMe Me 88 [‌888‌]
Me Me 88 [‌888‌]
Me Me 88 [‌888‌]
MMM Me 88 [‌888‌]
MMM Me 88 [‌888‌]
8-MeeMM8 Me 88 [‌888‌]

Me eeeeeeeee ee eee eeeee eeeeee eee eee eeeeeeeeeee ee eeeeeeeeeeeeeeee eeeeeee 8,8-eeeeeeeee eeeeeee ee eeeeeeeeeee eeeeeeeeeeeee. Mee eee ee-eeeeeee eeee eeeeeeee e eeeeeeeee eeeeeeeee eee eee eeeeeeeeeee ee eeeee 8,8-eeeeeeeeeeeeeeee 888 eeeeeee eee eeeeee eeee-eeeeeeeee eeeeeeeee ee eeeeeeeeee, ee eeeeeeeeeeeeeeeeeeeeee, eeeeeeee eeeeeeeee, eee eeeeee 8,8-eeeeeeeee ee eeeeee eeee (Meeeee 88).[‌888‌] Meee eeee eeee-eeeeeeeee eeeeeeee ee eeeeeee eee ee eeeeeee ee eeee eeeeeeeeeee eee 8 eee eeeeeee eeeee eee eeeeeeee, e eeeeeeeee eeee eeeeeee eeeee eeeee, eeeeeeeee eeeeeeeeeeeeeee 8,8-eeeeeee-8M-eeeeee 888 ee eeee eeeeee.[‌888‌]

Meee eee eeeeee 8,8-eeeeeee Meeeeeeʼe eeee ee eeee ee eeee eeeeeeeee ee eee eeeeeeee ee eeeeeeeeeeeee ee e eeee eeeeeeee ee eeeeeeee eeeeeeeeeee (88–88 °M) eee 8 eeeee, 8,8-eeeeeeeeeeeeee-8(8M)-eeee 888 eee eeeeeeee ee eeeeeeee eeeeee.[‌888‌]

Meeeee eeeeeeeeeeeeee eeeeeeeeeeeeeeee 8,8-eeeeeeeeeeeeeeee 888 eee eeeeeeeeeee ee eeeeeeee ee eeee eeeeee eee e-eeeeeee-eeeeeeeee eee-eee eeeeeeeeeeeeee eeeeeeeee ee eeeeeee eeeeeeeeeeeeeeeeeeeeeee, eeeeee, β-eeeeeeeeee eeeeeeeee, eee eeeeeeeee eeeee eeee eeeeeeeeee.[‌888‌]

Mee eeeee eeeeeeeeeeeeee eeeeeeee eeeeeeeee eeeeeee eeeeeeeeeeeeee/Meeeeeeeeee eeeeeeeeeeee/Meeeeee-eeee eeeeeeee/eeeeeeeeeeeeee eeeeeeeeeee eeeeeeeee ee eeee eeeeeeee eee eeeee eeeeeeeeeee 888888.

Meeeee 88 Meeeeeeeeee ee Meeeeeeeeeeeeeee ee Meeeeeeee 8,8-Meeeeeeeee Meeeeeeee[‌888‌‌888‌]

Meeeeeeeeee 88

Me8 M8 Me8 Meeee (%) Mee
8-Mee Me Me 88 [‌888‌]
8-MeM8M8 Me 8-Mee 88 [‌888‌]
8-MeMM8M8 Me 8-M8MM8M8 88 [‌888‌]
8-Mee M 8-MeM8M8 88 [‌888‌]
8-MeM8M8 M 8-Mee 88 [‌888‌]
8-Mee M 8-e-MeM8M8 88 [‌888‌]
8-MeMM8M8 M 8-eMeM8M8 88 [‌888‌]

Meeeeeeeeee 88M

M8 M8 M8 M8 Me8 Meeee (%) Mee
Me 8-Mee MM8MMe8MM8 8-MeM8M8 88 [‌888‌]
Me 8-MeM8M8 MM8MMe8MM8 8-Mee 88 [‌888‌]
Me 8-MeMM8M8 MM8MMe8MM8 8-Me8MM8M8 88 [‌888‌]
Me Me MM8MMe8MM8 8-MM8M8 88 [‌888‌]
Me 8-Mee (MM8)8 8-M8MM8M8 88 [‌888‌]
Me 8-MeM8M8 (MM8)8 8-MeM8M8 88 [‌888‌]
Me 8-MeMM8M8 8-MeM8M8 88 [‌888‌]
Me 8-Mee 8-M8MM8M8 88 [‌888‌]
Me 8-MeM8M8 8-Mee 88 [‌888‌]

Meeeeeeeeee 88M

Me8 Me8 Meeee (%) Mee
Me Me 88 [‌888‌]
8-MeM8M8 8-Mee 88 [‌888‌]
8-MeM8M8 8-MeM8M8 88 [‌888‌]

Meeeeeeeeee 88M

M8 M8 Meeee (%) Mee
Me Me 88 [‌888‌]
8-MeM8M8 Me 88 [‌888‌]
Me MMe 88 [‌888‌]

M eeeeee-eeee-eeeeeeeee eeeeeeee eeeeeeeee 8 eeeeeeeeee eeee ee ee eeeee, ee eeeeeeee, eee e β-eeeeeeeeee eeeeeeee ee eeeeeeeeeeeee eee 8 eeeeeeeeeee ee eeeeeeeeeeee ee eee eeeeeeee ee e-eeeeeee ee e-eeeeeee/eeee(MMM) eeeeeeee ee e eeeeeeee eeeee ee 8,8,8,8-eeeeeeeeeeeeeeeeeee 888 ee eeee eeeeee (Meeeee 88).[‌888‌] Mee eeee eeee ee eeeeee-eeee-eeeeeeeee eeeeeeeeeeee ee eeeeeeee eeee eeeeee eeeeeee ee e eeeeeeee, eeeeeee eeeeeeeeeeeeeee 8,8,8,8-eeeeeeeeeeeeeeeeeee 888.[‌888‌]

Meeeee 88 Meeeee-Meee-Meeeeeeee Meeeeeeee eee eee Meeeeeeee ee 8,8,8,8-Meeeeeeeeeeeeeeeeee[‌888‌,‌888‌]

Meeeeeeeeee 88

M8 Me8 M8 M8 M8 Meeee (%) Mee
Me Me Me MM8Me MM8Me 88 [‌888‌]
8-Mee Me Me Me Me 88 [‌888‌]
8-Mee Me Me Me MM8Me 88 [‌888‌]
8-Mee 8-Mee Me MM MM 88 [‌888‌]
8-MM8M8 Me Me MM MM 88 [‌888‌]
Me Me Me MM MM 88 [‌888‌]
Me Me Me Me MM8Me 88 [‌888‌]

Meeeeeeeeee 88M

M8 Meeee (%) Mee
Me 88 [‌888‌]
8-Mee 88 [‌888‌]
8-eeeeeeee 88 [‌888‌]
Me 88 [‌888‌]

Mee eeeeeeee ee eeeeeee eeeeee (8 eeeee), eeeeeee eeeeeeeeeeeeeeeeeeeeeee (8 eeeee), eee eeeee eeeeeeeeeee (8 eeeee) eeeeeeee eeeeeeee ee eeeeeeeeeeeeeee ee eeee eeeeeeeeeee eee eeeeeeee eeeeeeeeeeeeee 8,8-eeeeeeeeeeeeeeee 888 ee eeee eeeeee (Meeeee 88).[‌888‌] Me eeee eeeeeeee eee eeeeeeeeeeee eeeeeeeeeeee 888, eeeeee eeee eee eeeeeeeeee eee eeeeeee eeeeeeeeeeeeeeeeeeeeee, ee eeeeeeeeee ee eee eeeeeee eeeeeee 888, eeeeeeeee ee eeee eeee eee eeeeeee eeeee eee e eeeeee eeeeeee eeeeeeeeeeeeeeeeeeeeee, ee eeeeeee eeeeeeeeeeeee 888 eee 888. Mee eeeeeeeeee 888, eeeeeeee eeee eee eeeeeeee ee 888 ee 888, eeeeeeeee e eeeeeeeeeee, eeeeeeeee 888, eeeee ee eeeeeeeee eeee 888 ee eeeeee eeeeeeee.

Meeeee 88 Meeeeeeeeee ee Meeeeeeeeeeeee 8,8-Meeeeeeeeeeeeeee[‌888‌]

Meeeeeeeeee 88

M8 M8 M8 M8 Meeee (%) Mee
Me Me Me Me 88 [‌888‌]
e-Me Me 8-MeeMM8 Me 88 [‌888‌]
Me Me MMM Me 88 [‌888‌]
Me Me 8-eeeeeeeeeeeeee Me 88 [‌888‌]
e-Me Me MMM Me 88 [‌888‌]
Me Me Me Me 88 [‌888‌]
Me Me MMM Me 88 [‌888‌]
Me Me 8-MeM8M8MM8 Me 88 [‌888‌]
Me Me Me Me 88 [‌888‌]

Meeeeeeeeeee Meeeeeeee

Meeeeeeee 8-Meeeee-8-eee-8,8-eeeeeeeeeeeeeee-8,8,8-eeeeeeeeeeeeee (88, M8 = M8 = MM8Me; M8 = Me; M8 = Me); Meeeeee Meeeeeeee:[‌88‌]

Me e eeeeeee eeee ee MeMM8 (888 ee, 8 eeee) eee MMMM (888 ee, 8 eeee) ee MeMM (8 eM), eee eeeee 8-eeeeeeeeeeeeeee (88 ee, 8.8 eeee) ee ee. Meeee eeeeeeeeee ee eee eeeeeeee (8.8 e), eee eeeeeee eee eeeeeeeeee eee eee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee [eeeeee eee (888–888 eeee), MeMMe/eeeeee 8:8] ee eeee e eeeeeeeee eeeeee; eeeee: 888 ee (88%).

Meeeeeee 8-Meeeee-8-(8-eeeeeeeeeeee)-8M-eeeeeee-8,8-eeeeeeeeeeeee (88, M8 = Me; M8 = Me; Me8 = 8-MeM8M8); Meeeeee Meeeeeeee:[‌88‌]

Me e eeeee-eeeeeeee eeeee eeeeeeee eeee e eeeeeeee eeeeeee, MMMM (888 ee, 8.8 eeee) eee MeMM8 (888 ee, 8.8 eeee) ee eeeeeee (88 eM) eeee eeeeeee eeeeeeeeee ee ee. Meee, 8-eeeeee-8-(8-eeeeeeeeee)eeeeeee (88, Me8 = 8-MeM8M8; 888 ee, 8 eeee) eee MeMe8 (88 ee, 88 eee%) eeee eeeee, eee eee eeeeeee eee eeeeee eeeee eeeeee eeeeeeeeee. Mee eeeeeeee eee eeeeeeee eeeee 8 e. Mee eeeeeee eee eeeeeeee eee eee eeeeeee eee eeeeeee eeeee eeeeeee eeeeeeee. Meeeeee eeeeeeeeeeee ee eeeeeeeeeee MMM (eeeeee/MeMMe 8:8) eeee e eeeeee eee; eeeee: 88%.

Meeeee 8′,8-Meeee-8-(8-eeeeeeeeee)-8M-eeeee[eeeee-8,8′-eeeeeeee]-8-eeeeeeeeeee (88, Me8 = 8-Mee); Meeeeee Meeeeeeee:[‌88‌]

Meeeee (eeeeeeee-8,8-eeeee; 888 ee, 8 eeee), 8-MeeMM8 (888 ee, 8 eeee), eee MMMM (888 ee, 8 eeee) eeee eeeeeee ee ee ee MeMM ee eee eeeeeeee ee Me8M (88 ee, 88 eee%) eee 8 e. Mee eeeeeeeee eeeeeeeeeeee 88 eee eeeeeeeee ee eeeeeeeeee eee eeeeeeeeeeeeee (MeMM) ee eeeeee eee eeee eeeeeee ee e eeeeee eeeee; eeeee: 888 ee (88%).

8,8- eee 8,8-Meeeeeeeeeeeeeee 88 eee 88; Meeeeee Meeeeeeee:[‌88‌]

Me e eeeeeee eeee ee MMMM (888 ee, 8 eeee) ee MMM (8 eM) eee eeeee eee eeeeeee eeeee (8 eeee) ee ee. Meeee 88 eee ee eeeeeeee, eee α,β-eeeeeeeeeee eeeeeeee (8.8 eeee) eee MMM (88 ee, 8.8 eeee) eeee eeeeeeeeeeee eeeee eee eeeeeeee eee eeeeeeeee. Meeee eeeeeeeeee ee eee eeeeeeee (eeeeeeeee ee MMM), eee eeeeeee eee eeeeeeeeeee eeee ee MeMMM8 eee eeeeeeeee eeee MM8Me8 (8 × 88 eM). Mee eeeeeee eeeee eee eeeeee eeee M8M eee eeeee, eee eeeee (Me8MM8). Mee eeeeeee eee eeeeeee eeeee eeeeeee eeeeeeee eee eee eeeee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee (eeeeee eee, eeeeee/MeMMe/Me8M 88:8:8) ee eeeeee eee eeeeeeee 88 eee 88.

Meeeeeee 8-Meeeee-8-eeeeeee-8-eee-8,8-eeeeeeeeeeeeeee-8,8-eeeeeeeeeeeee (88, M8 = Me); Meeeeee Meeeeeeee:[‌88‌]

Me e eeeeeee eeee ee MMMM (888 ee, 8.8 eeee) eee MeMM8 (888 ee, 8 eeee) ee MM8Me8 (88 eM) eee eeeee eeeeeee eeeeeeeeee (888 ee, 8 eeee) ee ee. Mee eeeeeee eee eeee eeeeeee eee 88 e. Mee eeeeeee eee eeeeeee eeeee eeeeeee eeeeeeee eee eee eeeeeee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee [eeeeee eee (888–888 eeee), eeeeee/MeMMe] ee eeee e eeeee eeeeee; eeeee: 888 ee (88%).

Meeeeeee 8-Meeeee-8M-eeeeeee-8,8-eeeeeeeeeeeee (88, M8 = Me; M8 = Me); Meeeeee Meeeeeeee:[‌88‌]

β-Meeeeeeeeeee (88 eee%) eee eeeeeeeee ee M8M (88 eM), eee ee eeee eeeee eeee, MeMM8 (88 ee, 8 eeee) eee eeeee. Mee eeeeeee eee eeeeeee eee 88 eee, eee eeee MMMM (888 ee, 8 eeee) eee 8,8-eeeeeeeeeeeeeeeeeeeeeeee (88; 888 ee, 8 eeee) eeee eeeee. Meee eeeeeee eee eeeeee ee 88 °M eeeee eee eeeeeeee eee eeeeeeee, ee eeeeeeeee ee MMM. Mee eeeeeee eee eeeeee ee 8 °M eee β-eeeeeeeeeeee eee eeeeeee ee eeeeeeeeee. Mee eeeeeee eeeee eee eeeeeeeee eeee MeMMe (8 × 88 eM), eee eee eeeeeeee eeeeeee eeeeee eeee eeeeee eeee M8M eee eee. eeeee, eee eeeee (Me8MM8). Mee eeeeeeee eeeeeee eeeeee eeee eeeeeeeeeeee eeeee eeeeeee eeeeeeee eee eee eeeeeeeee eeeee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee (MeMMe/eeeeee 8:88) ee eeee e eeeeee eee; eeeee: 88%.

Meeeeee 8-Meeee-8-eeeeee-8,8,8-eeeeeeeee-8,8-eeeeeee-8M-eeeeeee-8,8-eeeeeeeeeeeee (88, M8 = Me; M8 = M8 = Me; M8 = M8 = Me); Meeeeee Meeeeeeee:[‌88‌]

Me e eeee ee Me8MM (88 ee, 8.8 eeee) ee eee MM8Me8 (8 eM) eee eeeee eeeeeee eeeeeeeeeeeeeeeeeeeeee (88 ee, 8.8 eeee), eee eee eeee eee eeeeeee eee 88 eee ee ee. Meee, 8,8,8-eeeeeeeeeeeee-8-ee-8-ee (888 ee, 8.8 eeee), 8-Å eeeeeeeee eeeeee (888 ee), eee MM8•MMe8 (88 ee, 8.8 eeee) eeee eeeee ee eeeeeeee. Meeee eeeee eeeeeee ee eeeeee eeeeeeeeeee eee 8 e, eee eeeeeee eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Mee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee (eeeeee eee, eeeeee/MeMMe/Me8M 88:8:8.8) ee e eeeeee eeeee; eeeee: 88%.

Meeeee 8-(Meeeeeeeeeeeee)-8,8-eeeeeee-8M-8,8-eeeeeeeeeeeeee-8-eeeeeeeeeeee 888 (M8 = M); Meeeeee Meeeeeeee:[‌88‌]

Meeeeee-8,8-eeeeeee (88 ee, 8.8 eeee), eee eeeeee eeeeeeeeeeee-8-eeeeee (8.8 eeee), eee ee eeeeeeee (8.8 eeee) ee MeMM (8 eM) eeee eeeeeeee eee 88–88 e. Meeee eeeeeeeeee ee eee eeeeeeee, eee eeeeeee eee eeeeeeeeee eee eee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee.

Meeeee (M)-8-(Meeeeeee-8-ee)-8-[(eeeeeeeeeeeeee)eeeeeeeee]eeeeeeee [888, M8 = Me; M8 = M; M8,M8 = (MM8)8; Me8 = Me]; Meeeeee Meeeeeeee:[‌88‌]

M eeee ee eeeeee eeeeeeeeee (88 ee, 8 eeee) eee eeeeeeeee (88 ee, 8 eeee) ee eeeee eeeeeee (8 eM) eee eeeeeeeeeeee eeeeeee eee 8 e. Me eeee eeee eee eeeee eeeeeeee e eeee ee eeeeeeeeeeeeeee eeeeeeeeee (888 ee, 8 eeee) ee eeeee eeeeeee (8 eM) ee 88 °M eee eee eeeeeee eee eeeeeee eee 88 e. Mee eeeeeee eee eeeeeee eeeee eeeeeee eeeeeeee, eee eee eeeeeee eee eeeeeeeee ee eeeeee eeeeeeeeeeeeee [eeeeee eee (888–888 eeee), eeeeee/MeMMe 8:8] ee eeee e eeeeee eeeeee; eeeee: 888 ee (88%).

Meeeee 8-Mee-8-[8-eee-8,8-eeeeeeeeeeeeeeeee-8(8M)-eeeeeee]-8-[(eeeeeeeeeeeeee)eeeee]eeeeeeeeee (888, M8 = Me; M8 = MM8Me); Meeeeee Meeeeeeee:[‌88‌]

M eeee ee eeeeeee-8,8-eeeeeee (888 ee, 8 eeee) eee MMMM (888 ee, 8 eeee) ee eeeee MM8Me8 (8 eM) eee eeeeeeeeeeee eeeeeee eee 88 eee. Meeeeeeeeeeeeee eeeeeeeeee (888 ee, 8 eeee) eee eeeee, eee eee eeeeeee eee eeeeeee eee 88 e ee 88 °M. Mee eeeeeeeeeee eee eeeeeeeee ee eeeeeeeeee eee eeeeee eeee Me8M (8 eM), MeMMe (8 eM), eee eeeeeee eeee eeee MM8Me8 (8 eM) ee eeee e eeeeee eeeeee; eeeee: 888 ee (88%).

8-Meee-8-eeeeeee-8M-eeeeee-8(8M)-eeee 888; Meeeeee Meeeeeeee:[‌88‌]

Me e 88-eM eeeee, e eeee ee ee eeeeeeee eeeeeeee (8 eeee), ee eeeeeeeee (8 eeee), eee MeMM (88 ee, 8.8 eeee) ee MeMM (8 eM) eee eeeeeee ee ee eee eeeeeeeeeeeee 88 eee. Mee eeeeeee eeeeeeeeeeeeeeeeeeeeee (8 eeee) eee eeee eeeee, eee eee eeeeeee eee eeeeeee ee ee eee 88 e. Mee eeeeeeeee eeeeeeeeeee eee eeeeeeeee eee eeeeee eeee eeee MeMM ee eeee e eeeee eeeeee eeeee; eeeee: 88–88%.

8,8-Meeeeeeeeeeeeeee-8(8M)-eeee 888; Meeeeee Meeeeeeee:[‌88‌]

Me eeeeeeee (8.8 eeee) ee eeeeeee (8 eM), eee MeMe8 (88 ee, 8.8 eeee) eeee eeeeeeeeeeee eeeee ee e eeeeeeee eeeeeee ee eeeeeee eeeeeeeeeeeeeeeeeeeeee (8 eeee) eee ee eeeeeee (8 eeee). Mee eeeeeee eee eeeeeee ee 888 °M eee 88 e eee eeee eeeeeee eeee Me8M (88 eM), eeeee (MeMM8), eeeeeeee, eee eeeeee eeee Me8M (8 × 8 eM). Mee eeeeeeee eeeeeee eeeeee eeee eeeeeeeeeeee eeeee eeeeeee eeeeeeee eee eee eeeee eeeeeee eee eeeeeeee ee eeeeeeeeeee MMM (eeeeee/MeMMe 88:8); eeeee: 88–88%.

Meeee 8-Meeee-8-eee-8,8-eeeeeee-8M-eeeeeee-8-eeeeeeeeeeee 888; Meeeeee Meeeeeeee:[‌88‌]

Me eeeeeeee (8 eeee) eee e eeeeeee eeeeeeeee eeeee (8 eeee) eeee eeeee eeeeeeee eeee e eeeeeee ee MeMM (8 eM), eeeeeee eeeeeeeeeeeeeeeeeeeeee (8 eeee), eee ee eeeeeeee eeeee (8 eeee) eeee ee ee eee 88–88 eee ee eeeeeeee, eeeeeeee ee eeeeeeee ee ee ee 88 °M. Mee eeeeeeee eee eeeeeeeee ee MMM. Meeee eeeeeeeeee ee eee eeeeeeee, eee eeeeeee eeeeeee eee eeeeeeee ee eeeeeeeeeee MMM (eeeeee/MeMMe 88:8 ee 8:8); eeeee: 88–88%.

Meeeeeee 8-Meeee-8-eeee-8-eeeeee-8-eeeee-8,8-eeeeeeeeeeeeeee-8,8-eeeeeeeeeeeeee 888 (M8 = Me; M8 = Me; M8 = MM8Me; MMM = MM); Meeeeee Meeeeeeee:[‌88‌]

M eeeeeee ee MMMM (8 eeee) eee MeMM8 (8.8 eeee) eee eeeeeeeeee eeeeeee ee ee eee 8 e (eeeeeeee eeeeeee). Meee, e eeeeeee ee e eeeeeeeeeeee eeeeeeeeee (8 eeee), eeeeeeeeeeeee (888 ee, 8 eeee), eee (MM8)8MMM8 (88 ee, 88 eee%) ee M8M/MeMM (8:8; 88 eM) eee eeeee, eee eee eeeeeeeee eeeeeee eee eeeeeee ee ee eee 88–88 e (MMM eeeeeeeeee). Mee eeeeeee eee eeeeeeeeee eee eee eeeeeeeeeee eee eeeeeeee ee eeeeeeeeeeeeeeeee (eeeeeeeee eeeee/MM8Me8).

Meeee 8′-Meeee-8′-eeeee-8-eeeeeeee[eeeeeeee-8,8′-eeeee]-8′-eeeeeeeeeeee 888 (M8 = M); Meeeeee Meeeeeeee:[‌888‌]

M eeeeeee ee eeeeee (eeeeeeee-8,8-eeeee; 888 ee, 8 eeee) eee eeeeeeeeeeeee (88 ee, 8 eeee) ee MeMM (8 eM) eee eeeeeee eee 88 eee eee eeee eeeeeee eeee e eeee ee eeeeeee eeeeeeeeeeeeeeeeeeeeee (8 eeee) eee 8,8-eeeeeeeeeeeeeee (888; 888 ee, 8 eeee) ee MeMM (8 eM). Mee eeeeeee eee eeeeeee ee ee eee 8 e. Meeee eeeeeeeeee ee eee eeeeeeee, eeeeeeeeee ee MMM (MeMMe/eeeeee 8:8), eee eeeeeee eee eeeeeeee eee eee eeeeeeeeeee eee eeeeee eeee M8M (8 eM) eee MeMM (8 eM) ee eeeeee eee eeee eeeeeee; eeeee: 88–88%.

Meeeeee 88-Meeee-88-eeeee-8-eee-8,8-eeeeeee-8e,8e-(eeeeeeeeeee)eeeeee[8,8-e]eeeeeee-8,8-eeeeeeeeeeeeee 888; Meeeeee Meeeeeeee:[‌888‌]

Me e eeee ee eeeeeeeee (888 ee, 8 eeee) eee eeeeeeeeeeeee (88 ee, 8 eeee) ee M8M (8 eM) eee eeeee Me8M (88 ee, 8.8 eeee), eee eee eeee eee eeeeeee eee 8 e ee ee. Meee, eee eeeeeee eeeeeeeeeeeeeeeeeeeeee (8 eeee) eee e eeeeeee eeeee (8 eeee) eeee eeeee ee eeee eee eeeeeeee eeee 88 eee, eeeeeeeeeeee. Meee eeeeeeeeee ee eee eeeeeeee (88–88 eee), ee eeeeeeeee ee MMM, eee eeeeeee eee eeeeeeee ee eeee eee eeeee eeeeeee, eeeee eee eeeeeee eeeeee eeee 88% MeMM; eeeee: 88–88%.

Meeeeeee 8,8-Meeeee-8,8-eeeeeeee-8-eee-8,8,8,8,8,8-eeeeeeeeeeeeeeeeee-8,8-eeeeeeeeeeeeee 888 (M8 = Me); Meeeeee Meeeeeeee:[‌888‌]

Me e eeeee-eeeeeeee eeeee, e eeee ee ee eeeeeeeee (8 eeee) eee MMMM (8 eeee) ee MeMM (8 eM) eee eeeeeee ee ee eeeeeeeee. Meee, eee eeeeeeee eeeeeeee (8 eeee) eee 8,8-eeeeeeeeeeeeeeeeeee-8,8-eeeee (888 ee, 8 eeee) eeee eeeee, eee eee eeeee eeeeeee eee eeeeee ee 88–88 °M eee 88 e eee eeee eeeeee ee ee. M8M (88 eM) eee eeeee, eee eee eeeeeeeee eeeeeeeeeee eee eeeeeeeee eee eeeeeeeee ee eeeee-eeeee eeeeeeeeeeeeee (eeeeee eee, MeMMe/eeeeeeeee eeeee 8:8); eeeee: 88–88%.

Meeeeee 8-Meeeee-8,8-eeeeeee-8,8,8,8-eeeeeeeeeeeeeeeeee-8,8-eeeeeeeeeeeee (888, M8 = Me); Meeeeee Meeeeeeee:[‌888‌]

MMMMMMM: Meeeeeeeeeee ee e eeeeeeee eeeee eeeeeeeeee, e eeeeee eee, eeee, eee eeeeeeeeeee eeeee eeeeeeee, eee e eeee eeeeeeeeee.

Me e eeeeeee ee eeeeeee eeeeeeeeeeeeeeeeeeeeee (888 ee, 8 eeee) eee eeeeeeeeeeeee (88 ee, 8 eeee) ee e eeeee-eeeeeeee eeeee eeee eeeeeeeeeeee eeeee MeMMe (8 eeee) eee MMMM (8 eM) eeeee eeeeeee eeeeeeeeee eeee eeeeeeee. Mee eeeeeee eee eeee eeeee eeeeeee eeeeeeeeee eee 8 e, eee eeee 88% MMMM (8 eeee) eee eeeee. Mee eeeeeeeee eeeeeee eee eeee eeeee eeeeeee eeeeeeeeee eee 8 e eee eeee MeMM8 (8 eeee) eee eeeee eeeeeeee, eeeee e eeeeeee 8 e, ee 88% MMMM (8 eeee) eeeeeeee; eee eeeeeee eee eeee eeee ee eeeee eee 8 e. Meeee eeeeeeeeee ee eee eeeeeeee, eee eeeeeee eee eeeeeee eeee M8M eee eeeeeeeee eeee Me8M. Mee Me8M eeeee eee eeeeee eeee eeeee, eee eeeee (MeMM8). Mee eeeeeeeee eeeeeee eee eeee eeeeeeee ee MM eee MM/MM. Meeeeeeee eeee eeeeeee eeeee eeeeeee eeeeeeee eee eee eeeeeee eee eeeeeeee ee MMMM (MM888, eeeeeeeee eeeee/Me8M 88:8); eeeee: 88%.

Meeeeeeeeee 8-Meeeee-8-(eeeeeeeeeeeeeee)-8,8-eeeeeeeeeeeeeee-8,8,8,8-eeeeeeeeeeeeeeee (888, M8 = Me; M8 = M8 = Me; M8 = Me); Meeeeee Meeeeeeee:[‌888‌]

Me e eeeeeee eeee ee MeMM8 (888 ee, 8 eeee) eee MMMM (888 ee, 8 eeee) ee MM8Me8 (88 eM), eee eeeee eeeeeeeeee eeeeeeeeee (888 ee, 8 eeee) ee −8 °M. Mee eeeeeee eee eeeeeee ee eeeee ee. Meeee eeeeeeeeee ee eee eeeeeeee (8–88 e), ee eeeeeeeee ee MMM (MeMMe/eeeeee 8:8), eee eeeeeee eee eeeeeeeeee, eee eee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee [eeeeee eee (888–888 eeee), eeeeee/MeMMe 8:8] ee eeee e eeeeee eeeeee; eeeee: 888 ee (88%).

References


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