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2.2.1.5.1 Three-Component Synthesis of Polysubstituted 1-Pyrroles

DOI: 10.1055/sos-SD-211-00064

Modha, S. G.; Van der Eycken, E. V.Science of Synthesis: Multicomponent Reactions, (20142299.

Polysubstituted 1H-pyrroles 27 can be synthesized via a copper-catalyzed three-component reaction (Scheme 14).[‌26‌] Thus, the reaction of α-diazo ketones 24 with amines 25 and nitroalkenes 26 in the presence of a catalytic amount of copper(I) trifluoromethanesulfonate, under air, gives polysubstituted 1H-pyrroles 27 in good yields.

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