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2.6.1.1.2.4 Indium-Mediated Synthesis of 2-Amino-4-1-benzopyrans

DOI: 10.1055/sos-SD-211-00177

Xi, C.; Chen, C.Science of Synthesis: Multicomponent Reactions, (20142445.

Indium has been used extensively in organic synthesis in an organic solvent. Reaction of variably substituted salicylaldehydes 19, malononitrile (20), and various allylic bromides 21 in water, in the presence of indium/sodium iodide, results in good yields of 2-amino-4H-1-benzopyrans 22 (Scheme 6).[‌13‌]

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