Science of Synthesis

Bronger, R. P. J.; Kamer, P. C. J.; Vogt, D., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2014) 1, 37.

Functionalized allylic substrates such as but-3-enenitrile have been explored mainly in the field of asymmetric hydroformylation aiming at the chiral branched product.[‌36‌] Claver and co-workers investigated the regioselectivity of the hydroformylation of allyl ethers for standard phosphine ligand types.[‌48‌] Cycloocta-1,5-diene[3-(dimethylamino)propanethiolato]rhodium(I) dimer [{Rh[μ-S(CH2)3NMe2](cod)}2] and the phosphine ligand were used to generate the active catalyst in situ.

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References