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1.1.7.1.2 Transition-Metal-Catalyzed Cyclopropanation Reactions

DOI: 10.1055/sos-SD-212-00164

Belderrain, T. R.; Nicasio, M. C.Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (20141263.

The decomposition of diazomethane in the presence of catalytic amounts of a transition-metal complex generates a metal carbene species that can react with alkenes, affording cyclopropane derivatives (Scheme 5);[‌36‌‌38‌] see also Science of Synthesis, Vol. 48 [Alkanes (Section 48.2.1.4.2)].

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Meeeee 8 Meeeeeeee-Meeeeeeee Meeeeeeeeeeeeeee ee Meeeeee eeee Me Meee Meeeeeeee Meeeeeeeeeee[‌88‌,‌88‌]

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Meeeee 8 Meeeee Meeeeeeeeee Meee ee Meeeeeeee-Meeeeeeee Meeeeeeeeeeeeeee ee Meeeeee eeee Meeeeeeeeeee[‌88‌‌88‌]

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Meeeee 8 Meeeeeeeeeeeeeee ee Meeeeeeeeeeeeeeeee Meeeeeeeeee eeee Meeeeeeeeeee eeeee Meeeeeeee eee Meeeee Meeeeeeee[‌88‌‌88‌]

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Mee eeeeeeeeeee eeeeeeee (8.8 eee), eee eeeeeee (88–888 eM), eee 88% ee MMM (ee. 88 eM) eeee eeeeee ee e eeeee eeeeeeee eeee e eeeeeee, e eeeeeeeeeee eeeeeeee eeeeee, eee e eeeeee eeeeeeeee. Meee, eee eeeee eeeeeee ee M-eeeeee-M-eeeeeeeeeee (88; 8–8 e) eee Me-eeeee eeeeeeee (8.8 eeee) eeeeeeeee ee MM8Me8 (8 eM) eeee eeeee ee 88–88 °M. Meeeeeee ee eeeeeee eeeeeeee ee eeeee M-eeeeee-M-eeeeeeeeeee (88; ee. 8.8 e · eee−e; eeeee eeeeee 88–88 e, 8.88–8.88 eee) eee eeeeeee eee eeeee eee eeeee ee eee eeeeeeeee. Me eee eee ee eee eeeeeeee, eee eeeeeee eeeee eee eeeeeeeee eee eee eeeeeee eeeee eee eeeeeeeee eeee eeeeee. Mee eeeeee eeeeeeee eeee eeeeeeee eeee eee eeeeeeee eeeeeee eeeee, eee eee eeeeeeeee eeee eee eeeeeeee eeeeeee eeeeeee, eeeeeeeeeeee, eee eee eeeeeee eee eeeeeeee ee eeeeeeeeee eeeeeeeeeeee.

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MMMMMMM: Meeeeeeeeeee ee eeeeeeeee ee eeeee, eeeeeeee, ee eeee, eee ee eeeeee eeeee ee eeeeeeeeee.

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Meeeeeeeeeeee 88; Meeeeee Meeeeeeee:[‌88‌]

MMMMMMM: M-Meeeee-M-eeeeeee-8-eeeeeeeeeeeeeeeeee (M,8-eeeeeeee-M-eeeeeeeeeeeeeeeeeeeeeeeee, Meeeeee) eeeeeeeee eeeeeeeee eee eeeee eeeeeeeeeeee eeee eeeeeee eeee eeeeeee.

Meeeee(8,88,88,88-eeeeeeeeeeeeeeeeeeeeeee)eeee(MMM) (8–8 eee%) eee eeeeeeeee ee eee eeeeee eeeeeeeee (8.88 eeee) eee 8 M ee MMM eee eeeee ee ee eeee eeee. Me eeee eeeeeeeeee, eeeeeeee eeeeeee eeee (>8888 eee) eee eeeee 8.88 M ee eeeeee 8-(M-eeeeee-M-eeeeeeeeeeeeeeee)eeeeeeee[‌88‌] (88, Meeeeee; 8–8 eeeee) ee ee eeee e eeeeeee eeee. Meeee e eeeeeee 88 eee, eee eeee eee eeeeeee eeee M8M eee eeeeeeeee eeee MM8Me8 (8 ×). Mee eeeeeee eeeeee eeee eeeee (MeMM8) eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Meeee MMM eeeeeeee ee eee eeeee eeeeeee, eee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeeee/Me8M) ee eeeeee eee eeee eeeeeee.

References


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