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1.1.8 Addition of Carbon Dioxide to Alkenes and Other Unsaturated Hydrocarbons

DOI: 10.1055/sos-SD-212-00170

Takaya, J.; Iwasawa, N.Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (20141281.

General Introduction

Utilization of carbon dioxide in C—C bond-forming reactions with organic substrates has been employed as an efficient method for the synthesis of carboxylic acid derivatives. The nucleophilic addition of reactive organometallic reagents, such as Grignard reagents and organolithium compounds, to carbon dioxide to give carboxylic acids is a classical, but reliable and versatile, reaction (see Section 2.5.4). However, the organometallic reagents are typically prepared from costly organic halides and there are often compatibility problems with other functional groups due to their high basicity and nucleophilicity. The development of atom-economical carbon dioxide fixation reactions under mild conditions has been a very important issue not only from the standpoint of synthetic methodology but also from that of reusable carbon resources.

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