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1.1.10.2 Cyanation

DOI: 10.1055/sos-SD-212-00203

Goldfuss, B.Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (20141365.

1,4-Addition of hydrogen cyanide to α,β-unsaturated carboxylic acid derivatives produces β-cyano carbonyl compounds, which are very useful building blocks in organic synthesis. Reduction of the cyanide moiety leads to γ-amino acids, hydrolysis produces 1,2-dicarboxylic acids, and Curtius rearrangement results in β-amino acids.

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