Science of Synthesis

Goldfuss, B., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2014) 1, 375.

Deng and co-workers have investigated a series of chiral phase-transfer catalysts for the regioselective, asymmetric conjugate addition of cyanide to enones and α,β-unsaturated 1-acylpyrroles to give products ‌54‌ and ‌55‌. The best results are achieved using acetone cyanohydrin as the cyanide source and cupreidinium salt ‌52‌ or cupreinium salt ‌53‌, which provide products with S- and R-configurations, respectively (‌Scheme 51‌).[‌89‌]

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References