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2.2.1.4.3 Methylation of Other Systems

DOI: 10.1055/sos-SD-213-00015

Molander, G. A.; Ryu, D.Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2014259.

In addition to iron, cobalt has also been employed as a catalyst in coupling reactions. In particular, tris(acetylacetonato)cobalt(III) has proven effective in a nitrogen-directed C—H insertion reaction employing methylmagnesium bromide (Scheme 32).[‌36‌] A drawback of this process is that 2,3-dichlorobutane must be employed as a stoichiometric oxidant, and 4 equivalents of the Grignard reagent is required, severely impacting both the atom economy and the functional group tolerance of the transformation.

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