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1.4.2.1.2.1 By Nitrile Hydratase

DOI: 10.1055/sos-SD-214-00194

Martínková, L.; Veselá, A. B.Science of Synthesis: Biocatalysis in Organic Synthesis, (20151279.

N-Unsubstituted 3-oxo amides 5 can be prepared from the corresponding 3-oxo nitriles 4 by using whole cells with nitrile hydratase activity. The amidase activity is suppressed by adding diethyl phosphoramidate (DEPA) to the growth medium.[‌21‌] The products are mixtures of the keto and enol form, 5 and 6, respectively (Scheme 3).

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