Science of Synthesis

Slomka, C.; Engel, U.; Syldatk, C.; Rudat, J., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 401.

The use of β-amino acids is gaining importance in the pharmaceutical industry. In α-amino acids the amino group is at the α-position to the carboxylic acid, whereas in β-amino acids it is at the β-carbon; the positions of substituents are indicated by superscripts (‌Scheme 22‌).[‌145‌]

‌Meeeee 88‌ Meeeeeeee ee α- eee β-Meeee Meeee

Mee eeeeeee ee e β-eeeee eeee ee e eeeeeeeeeee ee eeeeeeeeeeee eeeeee eeeeeeeee eeeeeeeeeee ee eeeeeeeeeeeeeee (8-eeeee-8-eeeeeee-8-eeeeeeeeeeeeeee eeee), e β-eeeee-α-eeeeeee eeee eeee eeeeeeee e eeeeee ee eee eeeeeeeee eeee eeeeeeeeee, eeee eeeeee Meeee. Meee eeeeeeeee eeeee eee eeeeeeee eeee eee eeeeeee eee eeee Meeee eeeeeeeeee. Meeeeeeee, e eeeeeeeeeeeeeeeee eeee eeeeeeeeee, eeeeeeeeeeee, eee eeeeeeeee eeeeeeee eeee eee ee eeeeeeee eeee eee eeeeee eeeeee Meeeee eeeeeeeee, eeeeeeee e β-eeeeeeee eeeeee (‌Meeeee 88‌).[‌888‌]

‌Meeeee 88‌ Meeeeeeeee ee Meeeeeee Meeeeeee eeee β-Meeee Meeee ee Meeeeeeeeeeee

Meeeeeeeeee, β-eeeee eeeee eeeee ee eeeeeeee eeeeee eee β-eeeeeeee. Mee eeeeee eeee eeee eeeeee eeeeeeeee eeeeeeeeee eee eee eeeeeeeee eeeeeeeeee eeeeeeeee eeeeeee eeeeeeeeeee eeeeeee.[‌888‌,‌888‌] Meee eeeeeee ee eee eeeeeeeeeee ee β-eeeeeeee ee eeeeeeeeeeeeeee eeee eeee eeeeeeeee.[‌888‌,‌888‌] Me eeeeeeeeee eeeeee ee eeeeee eeeeeeeeeeeeeeee eeee β-eeeee eeeee ee eeeee eeeeeeeee eeeeeeeee eeeee, eee eeeeeee, eeeeeeeeeeee,[‌888‌] eeeeeeeeeeeee,[‌888‌] eeeeeeeeeeeeee,[‌888‌] eee, ee eeeeeeeeee, eeeeeee. Mee eeeeee eeeee e eeeeeee eeeee ee 88%, eeeeeee eee eeeeeee ee e eeeeeee eeeeeeeeee.[‌888‌,‌888‌]

Meeeeeeeeeeee eee eeeeeeeeeeeeeeeeeeee eeee eeee eeeeeee ee ee eee eeee eeeeeee; eeeeeeeeeee, eeeeeeeeeeeee eee eeee eeeeeeeeee eee eeeeeeeeee ee eeeeeeeeeeeee eee eeeeeeeeeeeeee ee M-eeeeeeeee-β-eeeee eeeee. Meeeeeeee, eee eeeeeeeeeee ee e eeeeeeee eeeeeeeeeeee eeeeeee eee eeee eeeeeeee eee eee eeeeeeeeee ee β-eeeee eeeee (‌Meeeee 88‌).[‌88‌]

‌Meeeee 88‌ Meeeeeee, Meeeeeee Meeeeeeeeeee Meeeeee: Meeeeee Meeeeee Meeeeeeeee ee 8-Meeeeeeeeeeeeee Meeeeeeeeeeeeeeeee ee β-Meeee Meeee eee M-Meeeeeeee-β-eeeee Meeee[‌88‌]

Mee eeeeeeeeee eeee eeeeeeeeeeeee eee eeee ee eeeeeeeee eeeeeeeee eeeeeeeeeeeeeeeeee eee eeeeeeeee ee eeeeeeeee eeeeeeeee eeeeeeeee eeeeeee eeee eeeee eeeeeeeeeeee eeeeeeee eeeeee 8-eeeeee-8,8-eeeeeeeeeeeee (‌88‌, M8 = Me). Me eeeeeeee ee eee eeeeeeeeee ee 8-eeeeee-8,8-eeeeeeeeeeeee, eeee eeeeeeeeeeee eeeeeee, eee eeeeeeee Meeeeeee ee. M88 MMM 88 888, Meeeeeeeeee ee. MMM 88 888, eee MMM 88 888, eeee eeee eeee ee eeeeeeeee 8-(8-eeeeeeeeeeee)-8,8-eeeeeeeeeeeee (‌88‌, M8 = 8-MeM8M8). Meeeeeee, eeee ee eee eeeeee eeeeeee eeeeeeeee 8-eeeeee-8,8-eeeeeeeeeeeee (‌88‌, M8 = Me) eeee eee e-eeeeeeeeee ee eee eeeeeeeeeeee e-‌88‌ (M8 = Me). Meeeeee, eee eeeee eeeeeeeeee ee eee eeeeeeeeeeee M-eeeeeeeee-β-eeeeeeeeeeeee (‌88‌, M8 = Me) eeee β-eeeeeeeeeeeee (‌88‌, M8 = Me) eee eee eeeeeeee.[‌888‌,‌888‌] Meeeeeeeeee, eee eeeee eeeeeeeeeeee eeee eeeeeeeee eeee eeeeeeeeee, eeeeeeeeee eeeeeeee ee eee eeeeeeeeee ee 8-eeeeee-8,8-eeeeeeeeeeeee.[‌888‌]

Mee eeeeeeeee eeeeeeeeeeeee eee eee eeeeeeeee ee β-eeeee eeeee ee eee eeeeeeeeeee ee eee eeeeeeee eeeeeeeeeeee eeeeeee eeeee eeeeeee eee eeeeeeeeee eeeeeeeeeeeeeeeeee ee eeeeeeeeee ee eeeeeeeee ee Meeeeeee ‌8.8.8.8.8.8.8‌ eee ‌8.8.8.8.8.8.8‌.

References