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1.4.5.4.1.3.1 Synthesis of l-β-Phenylalanine

DOI: 10.1055/sos-SD-214-00283

Slomka, C.; Engel, U.; Syldatk, C.; Rudat, J.Science of Synthesis: Biocatalysis in Organic Synthesis, (20151403.

Until 2011, the enantioselective hydrolysis of 6-substituted 5,6-dihydrouracils to their corresponding N-carbamoyl derivatives had not been well studied. However, an investigation of the substrate spectrum of the hydantoinase from Vigna vulgaris showed that it could be utilized for the synthesis of optically pure β-amino acids. d,l-6-Phenyl-5,6-dihydrouracil (d,l-31) is prepared by chemical synthesis as a substrate for the synthesis of l-β-phenylalanine (l-33) (Scheme 25).[‌159‌,‌160‌]

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References


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