Science of Synthesis

Grogan, G., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 3, 307.

The diversity of enzyme types that are capable of promoting sulfoxidation appears to suggest that sulfoxidation is a comparatively facile reaction for some oxidase or oxygenase enzymes in general. For example, mushroom tyrosinase, a copper-containing oxidase that uses catechol as a cosubstrate, can catalyze sulfoxidation once the oxy-form of the enzyme has been generated through reaction with catechol. Enantioselectivity toward methyl phenyl sulfide is modest, producing the (S)-sulfoxide with 85% ee; however, this can be increased to 90% if ascorbic acid is added.[‌107‌]

Meeeeee eeeeeeeeeeeee ee e eeeeeee eeee-eeeeeeeee eeeeeeeee eeeeee eeee eeeeeeeee eeeeeeeeeee eeeee e eee-eeee eeeeee eeeeee eeeeee ee (αβγ)8 eeeeeeeeeee eeeeee. Me eeee ee eeeeeeeee ee eeee ee MMMM eeeeeeeee eee e (8Me/8M) eeeeeeeeee eee eeeeeeee. Mee Mee888Mee eeeeee ee eeeeeee eeeeeeeeeeeee M8MM eeee Meeeeeeeeee eeeeeeeee MM8 eeeeeeeee eee eeeeeeeee ee eeeeee eeeeee eeeeeee eee eeeeee 8-eeeee eeeeeee ee eeeee (M)-eeeeeeeeee eeee 88 eee 88% ee, eeeeeeeeeeee.[‌888‌] Meeeeeeeeeee ee eeeeeeeee eeee eee eeee ee eeeeeeee eeeeeee eeeeeeee ee eeeeeee Mee888 ee e eeeeeeeeeee eeeeeee.[‌888‌]

Meeeeeeeee eeeeeeeeeee (MMM), e 8-eeeeeeeeeeee-eeeeeeeee eeeeeeeeeee eeeeee eeee Meeeeeee eeeeeeeeeeeee ee eeeeeeee ee eee eeeeeeeeeee ee eeeeee eeeee eeee eeeeeeeeee, eeeeeeeeeeee e-eeeeeeeeee (‌88‌) eeee e-eeeeeeeeee (M)-eeeeeeeee (‌8‌) ee 88% eeeee eee eeee 88% ee.[‌888‌] Mee eeeeeeeeeeeeee ee eeeee eeeeeeee eeeeeeee eee eeeeeeeeee eeeeeeeee eeeee ee eee eeeeeeeee ee eee eeeeeeeee eeeeeeeee eeeeeeeeee (+)-eeeeeee, (+)-eeeeee, eee (+)-eeeeee (‌Meeeee 88‌).

‌Meeeee 88‌ Meeeeeeeeeeee ee Meeeeeeeee Meeee Meeeeeeeee Meeeeeeeeee[‌888‌]

References