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3.7.2.2 Corticotropin Releasing Factor-1 Receptor Antagonist: Synthesis of (R)-sec-Butylamine and (R)-1-Cyclopropylethylamine by Enzymatic Transamination

DOI: 10.1055/sos-SD-216-00250

Patel, R. N.Science of Synthesis: Biocatalysis in Organic Synthesis, (20153406.

Numerous marketed treatments exist for anxiety and depression, which are psychiatric disorders that constitute a major health concern worldwide. However, there remains a need for agents that have increased effectiveness and/or reduced side-effects.[‌12‌‌14‌] Corticotropin releasing factor-1 (CRF-1) receptor antagonists have been proposed as pharmacological treatments for depression, anxiety, and stress disorders.[‌12‌‌15‌]

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