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1.1.2 Arylation Using a Palladium(II)/Palladium(IV) Catalyst System

DOI: 10.1055/sos-SD-217-00025

Gandeepan, P.; Cheng, C.-H.Science of Synthesis: Catalytic Transformations via C—H Activation, (2015169.

General Introduction

Aryl—aryl bonds are important structural motifs that are found in numerous natural products, agrochemicals, pharmaceuticals, and functional materials. Thus, new methods for the construction of aryl—aryl bonds have attracted great attention over the past few decades.[‌1‌] Classical methods for the synthesis of aryl—aryl bonds involve the transition-metal-catalyzed reactions of haloarenes or pseudohaloarenes with organometallic reagents (Suzuki–Miyaura, Stille, Hiyama, Kumada, and Negishi reactions).[‌2‌‌5‌] Despite the prominent development of these methods, some drawbacks still exist, including the prefunctionalization of the starting materials, the production of stoichiometric amounts of metal waste byproducts, and the high cost of the organometallic reagents. Therefore, the development of an environmentally friendly, cost-effective, and new synthetic strategy for the construction of aryl—aryl bonds through C—H activation is highly attractive.

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