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1.2.2.5 Hetarene C—H Activation/Carboxylation Reactions

DOI: 10.1055/sos-SD-217-00139

Nakao, Y.Science of Synthesis: Catalytic Transformations via C—H Activation, (20151428.

Carboxylation and alkoxycarbonylation of hetarenes have been developed by transition-metal catalysis. Based on pioneering studies,[‌238‌‌240‌] palladium-catalyzed oxidative alkoxycarbonylation of 1-alkylindoles 354 is achieved under an atmospheric pressure of air and carbon monoxide in the presence of alcohols 355 to give a variety of 1-alkyl-1H-indole-3-carboxylates 356 (Scheme 187).[‌241‌]

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