Science of Synthesis

Zhang, H.; Liu, C.; Lei, A., Science of Synthesis: Catalytic Transformations via C—H Activation, (2015) 2, 146.

A significant range of heterocyclic carboxylic esters ‌17‌ are obtained through copper(I)-catalyzed direct carboxylation of aromatic heterocyclic C—H bonds (‌Scheme 10‌).[‌22‌] Various substituted benzoxazoles ‌16‌ (X = O) afford the corresponding functionalized esters in moderate to good yields. Low yields are obtained when 1-methyl-1H-benzo[d]imidazole (‌16‌, X = NMe; R1 = R2 = R3 = H) and 2-phenyl-1,3,4-oxadiazole are employed as substrates. The reaction shows good functional-group tolerance.

‌Meeeee 88‌ Meeeee-Meeeeeeee M—M Meeeeeeeeeeee ee Meeeeeeee eeee Meeeee Meeeeee[‌88‌]

‌Meeeeeeeeee 88‌

e Meeeeeee eeeeee.

e Meeeeeee eeeee ee ‌88‌ (M8 = 8-e-MeM8MM8M8) ee eeeeeeeeeee.

Meeeeeeeeeee Meeeeeeee

Meeeeeeeeeeeeeeeee Meeeee ‌88‌; Meeeeee Meeeeeeee:[‌88‌]

Me e eeeeeeee, e-MeMM (888.8 ee, 8.8 eeee), MeMe(MMe) (88.8 ee, 8 eee%), eee MMM (8 eM) eeee eeeee eeee e 88-eM Meeeeee eeee eeeeeeee eeee e eeeeeeee eeeeeee eee eee e Meeeee eee. Mee eeeeee eeeeeeee eeee eee eeee eeeee eee ee eee eeeeeeee, eee eee eeeeeeeeeeee eeeeeeeee ‌88‌ (8.8 eeee) eee eeeee eeeee M8. Meeee eee eeeeeee eee eeee eeeeeeeee ee eeeeee eee e eeeee, MM8 (8 eee) eee eeeeeeeeee eeee eee eeee. Mee eeeeee Meeeeee eeee eee eeeeeee ee ee eee eeee ee 88 °M eee 88 e. Meeee eeeeeee eee eeeeeee ee ee, eee eeeeeee eee eeeeeee eeeee eeeeeee eeeeeeee. MMM (8 eM) eee 8-eeeeeeeeee (8.8 eeee) eeee eeeee ee eee eeeeeee eeeee e eeee ee M8. Mee eeeeee Meeeeee eeee eee eeeee eee eeee ee 88 °M eee eeee eee 8 e. Meeee eeeeeee eee eeeeeee ee ee, ee eee eeeeeee eeee MeMMe (88 eM) eee eeeeee eeee M8M (8 × 88 eM). Mee eeeeeee eeeee eee eeeee (Me8MM8) eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Mee eeeeeee eee eeeeeeee ee eeeee eeeeee eeeeeeeeeeeeee ee eeeeeeeeeee MMM.

References