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Please login or sign up for a free trial to access the full content. Synthesis of Xanthones

DOI: 10.1055/sos-SD-218-00088

Zhang, H.; Liu, C.; Lei, A.Science of Synthesis: Catalytic Transformations via C—H Activation, (20152150.

Xanthones 21 can be directly synthesized by palladium-catalyzed double C—H carbonylation of diaryl ethers 20 in the presence of a simple catalytic system consisting of palladium(II) acetate, potassium persulfate, and trifluoroacetic acid (Scheme 12).[‌24‌] A range of symmetrical and unsymmetrical diaryl ethers are carbonylated to form xanthones in good to high yields. In general, 4,4′-disubstituted substrates bearing either electron-donating or electron-withdrawing substituents work well under the optimized conditions and a variety of functional groups are tolerated. Monosubstituted and nonsubstituted diaryl ethers afford the desired products in relatively low yields.

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