Navigation

0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login or sign up for a free trial to access the full content.
2.6.2.1.1.1 Synthesis of Xanthones

DOI: 10.1055/sos-SD-218-00088

Zhang, H.; Liu, C.; Lei, A.Science of Synthesis: Catalytic Transformations via C—H Activation, (20152150.

Xanthones 21 can be directly synthesized by palladium-catalyzed double C—H carbonylation of diaryl ethers 20 in the presence of a simple catalytic system consisting of palladium(II) acetate, potassium persulfate, and trifluoroacetic acid (Scheme 12).[‌24‌] A range of symmetrical and unsymmetrical diaryl ethers are carbonylated to form xanthones in good to high yields. In general, 4,4′-disubstituted substrates bearing either electron-donating or electron-withdrawing substituents work well under the optimized conditions and a variety of functional groups are tolerated. Monosubstituted and nonsubstituted diaryl ethers afford the desired products in relatively low yields.

Meeeee 88 Meeeeeeee-Meeeeeeee M—M Meeeeeeeeeeee ee Meeeee Meeeee[‌88‌]

Meeeeeeeeee 88

M8 M8 M8 M8 M8 M8 M8 Meeeee (%) Mee
Me M M M Me M M 88 [‌88‌]
e-Me M M M e-Me M M 88 [‌88‌]
MMe M M M MMe M M 88 [‌88‌]
Me M M M Me M M 88 [‌88‌]
M (MM=MM)8 M M (MM=MM)8 88 [‌88‌]
Me M M M e-Me M M 88 [‌88‌]
Me M M M MMe M M 88 [‌88‌]
Me M M M MM8 M M 88 [‌88‌]
Me M M M MM8Me M M 88 [‌88‌]
Me M M M Me M M 88 [‌88‌]
Me M M M M M M 88 [‌88‌]
Me M M M Me M M 88 [‌88‌]
Me M M M Me M M 88 [‌88‌]
Me M M (MM=MM)8 M M 88 [‌88‌]
Me M M M Me M Me 88 [‌88‌]
Me M M Me Me M Me 88 [‌88‌]
M M M M Me M M 88 [‌88‌]
M M M M MMe M M 88 [‌88‌]
M M M M M M M 88 [‌88‌]
M M M M M M M 88 [‌88‌]

e Meeeeeee eeeeee.

Meeeeeeeeeee Meeeeeeee

Meeeeeeee 88; Meeeeee Meeeeeeee:[‌88‌]

MMMMMMM: Meeeee eeeeeeee ee eeeeeeeee eeeeeeeee eee eeeee, eee eeeeeeee ee eeeeee eeeeeeeeeeeeee eee eeeeeee eeee ee e eeee.

Me(MMe)8 (8.8 eee%), M8M8M8 (8 eeeee), eee e eeeeee eeeee 88 (8.8 eeee) eeee eeeeeeee ee ee eeee-eeeee Meeeeee eeee eeeeeeee eeee e eeeeeee eee. M eeeeeee eeeeee eeee MM eee eeeeeeeee ee eee Meeeeee eeee ee eee eeee eeee eee eee eeeeeeeee eee eeeeee eeeee eeeee. MMM (8.8 eM) eee eeeee ee eee eeee ee eeeeeee. Mee Meeeeee eeee eee eeeeee ee 88 °M eee 8–8 e (eee eeeeeeee eee eeeeeeeee ee MMM) eee eeee eeeeee ee ee. Mee eee eeee eee eeeeeee eee eeeeeeeee eeeeeeee, eee eeeeeeee eee eeeeeeee eeee M8M, eee eee eeeeeee eee eeeeeeeee eeee MM8Me8 (8 ×). Mee eeeeeeee eeeeeee eeeeee eeee eeeee (Me8MM8) eee eee eeeeeee eee eeeeeeeeee eeeee eeeeeee eeeeeeee. Mee eeeeeee eeeeeeee eeee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeee eee, eeeeeeeee eeeee/MeMMe).

References


Cookie-Einstellungen