Navigation

0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via
2.6.2.1.2.5 N-Alkoxy- and N-Alkylamido Directing Groups

DOI: 10.1055/sos-SD-218-00088

Zhang, H.; Liu, C.; Lei, A.Science of Synthesis: Catalytic Transformations via C—H Activation, (20152162.

A variety of N-methoxybenzamides 41 (R1 = Me) undergo ortho-selective C—H carbonylation to afford phthalimides 42 in the presence of palladium(II) acetate as catalyst and benzo-1,4-quinone as oxidant (Scheme 22).[‌34‌]

Meeeee 88 Meeeeeeee-Meeeeeeee M—M Meeeeeeeeeeee ee M-Meeeeeeeeeeeeeee[‌88‌]

Meeeeeeeeee 88

M8 M8 M8 M8 Meeeee (%) Mee
Me M M M 88 [‌88‌]
Me Me M M 88 [‌88‌]
Me M M Me 88 [‌88‌]
Me M M MM8 88 [‌88‌]
Me M Me Me 88 [‌88‌]
Me M MMe MMe 88 [‌88‌]
Me (MM=MM)8 M 88 [‌88‌]
Me M M M 88 [‌88‌]
Me M Me M 88 (8)e [‌88‌]
Me M MMe M 88 (88)e [‌88‌]

e Meeeeeee eeeeee.

e Meeee eee eee eeeeeeeeeee ee M—M eeeeeeeeeeeee ee M8 ee eeeeeeeeeee.

Meeeeeeeeeee 88 eee eeee ee eeeeeeee eeee M-eeeeeeeeeeeeeee 88 ee e eeeeeee eee eeeeeee eeeeeee(MMM)-eeeeeeeee eeeeeeeee M—M eeeeeeeeeeeee (Meeeee 88).[‌88‌]

Meeeee 88 Meeeeee-Meeeeeeee M—M Meeeeeeeeeeee ee M-Meeeeeeeeeeeeee[‌88‌]

Meeeeeeeeee 88

M8 M8 M8 Meeeee (%) Mee
Me M M 88 [‌88‌]
Me M M 88 [‌88‌]
(MM8)8Me M M 88 [‌88‌]
Me M M 88 [‌88‌]
(MM8)8Me M M 88 [‌88‌]
eMe M M 88 [‌88‌]
Me M MMe 88 [‌88‌]
Me M MMe 88 [‌88‌]
Me M MMe 88 [‌88‌]
Me M Me 88 [‌88‌]
Me M Me 88 [‌88‌]
Me Me M 88 [‌88‌]
Me MMe M 88 [‌88‌]
MM8MM8Me M M 88 [‌88‌]

e Meeeeeee eeeeee.

Meeeeeeeeeee Meeeeeeee

Meeeeeeeeeee 88; Meeeeee Meeeeeeee:[‌88‌]

MMMMMMM: Meeeee eeeeeeee ee eeeeeeeee eeeeeeeee eee eeeee, eee eeeeeeee ee eeeeee eeeeeeeeeeeeee eee eeeeeee eeee ee e eeee.

Me e “eeeeeee eeeeee” Meeeeee eeee eeeee MM eee eeeee MeMM (8.8 eM). MM eee eeee eeeeeee eeeeeee eee eeeeee eee 88 eee. Meeeee eeee eeee eee eeee eee eeeeee ee 88 °M. Meee, ee M-eeeeeeeeeeeeeee 88 (8.8 eeee), eeeee-8,8-eeeeeee (888 ee, 8.8 eeee), eee Me(MMe)8 (8 ee, 8.888 eeee) eeee eeeee. Mee eeeeee eeee eeeeeee ee eeeeeeee, eee eee eeeeee eee eeeeeeeee eee eeeeee eeee MM eeeee eee eeee eeeee e eeeeeee ee MM. Mee eeeeeee eee eeee eeeeee ee 888 °M eee eee eeeeeeee eee eeeeeeeee ee MMM. Meeee 88 e, eee eeeeeee eee eeeeeeeeeeee eee eee eeeeeee eee eeeeeeee ee eeeee eeeeee eeeeeeeeeeeeee.

8-Meeeeeeeeeeeeeee-8,8-eeeee (88, M8 = Me; M8 = M8 = M); Meeeeee Meeeeeeee:[‌88‌]

MMMMMMM: Meeeee eeeeeeee ee eeeeeeeee eeeeeeeee eee eeeee, eee eeeeeeee ee eeeeee eeeeeeeeeeeeee eee eeeeeee eeee ee e eeee.

Mee eeeeeeee eee eeeeeee eee ee e 88 × 888 ee eeee eeee eeeeee eeee e MM eeeeeee eeee eeeeeeee eeeeeeee ee 888 eee ee ee eee eeee. [Me(Me*)(MMMe)8](MeM8)8 (8.8 ee, 8.88 eeee) eeeeeeee ee M-eeeeeeeeeeeeee (88, M8 = Me; M8 = M8 = M; 88.8 ee, 8.8 eeee), Me8MM8 (888.8 ee, 8.88 eeee), MM8MM8 (88.8 ee, 8.88 eeee), eee 8-eeeeeeeeeee-8-ee (8.88 eM) eeee eeeee ee eee eeee eeee. Mee eeeeeee eee eeeeeee eeee MM eee eeee eee eeeeee eeee MM eeeeeeee eee eeeeee ee 888 °M eee 88 e eeeee eeeeeeee eeeeeeee. Meee eeeeeeeeee ee eee eeeeeeee, eee eeeeeee eee eeeeee ee ee eee eeeeeee eeee MeMMe eee eeee eeeeeeee eeeeeee e eeeee eee ee Meeeee. Mee eeeeeeee eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Mee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee (eeeeee eee); eeeee: 88 ee (88%).

References


Cookie-Einstellungen