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DOI: 10.1055/sos-SD-219-00001

Snyder, S. A.Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (201511.

There is something inherently satisfying about setting up a number of dominoes in series, pushing one down at the end of the chain, and watching the rest tumble as if in slow motion until all have been knocked over; I remember spending hours doing this as a child, once my father showed me the principle and I had enough dexterity to not knock anything down before the right moment. I felt the same way about playing with a Newtonʼs cradle, where, although the movement does not cease in the same way as a domino chain, the idea of setting something into motion and causing a series of subsequent reactions was certainly pleasing and mesmerizing to watch.

Me eeeee eeeeeeeeee eeee e “eeeeee”, ee “eeeeeee”, eeeeeeee ee eee eeeeeeeee eeeee eeee eeeee ee eee eeeee ee ee eeeeeeee eeeeee ee M. M. Meeeeeeeʼe eeeeeeeeee ee Mee Meeeeee Meeeeeee Meeeeeeee, ee eee eeeeee ee 8888. Mee eeeee M eeeeeee ee eeeeeeee eeeeeeeee ee eee eee eeeeee ee eeeeeee e eeeeeeeeee eeeeeeeee ee eeeeeeeeeeeee (8) (Meeeee 8) eeee eeeeeeeee eeeee ee eee eeeeeee eeeeeee eeeeeeeeeee, e.e. 8. Meeeeeee eeee eeeeeeeeee e eeeeee ee eeeeeeeee ee eeeeeee 8 eeee eeeeee ee eeeeee eeeee eeeeeee ee eee eeeeeeeeeeeeeeee eeeeee eeee eeeeeeee ee eeeeeeeee eeeeeeee eeeeeeeeee, eeeeeeeeeeeee eeeeee eeeeee eeeeeee.[‌8‌] Meee eee, eeeeeee eeeeeeeee eeeeeeee eeee eeeeeeeee eeee eeeeeeeeee eeeeeeeeeee, eee M eeeeeeee ee eeeeeeeeee eeeeeee eee eeeee eeee eeee eeeee eee eee eeeeeeeeeeee, eee eeee eeeeeeee eeeee eeee eeeeeeeeee ee eeeeee ee eee eeee ee eeeeeeeee eeeeeee eeeee ee eee eeeeeeeeee eeee eeeeeee eeee eeee eee eeeeeeee. Meeeeeeeee, ee eeee-eeeeeeeeeee eeeeeee, M. M. Meeee (ee eeeeee eeeeeeeeeeee eeeeeeeeee)[‌8‌] eee eee Meeeeeee eeee[‌8‌] eeeeeeeeee eeee eee eeeee eeeeeee ee eee eeeeeeee ee e eeeeeee eeee eee eee eee ee eee eeeeee eeeeee ee Meeeeee eeeeeeeee eee eeeeeeeeeeeee eeeeee ee eeee eee eeeeee eeeee eeeeeeeee ee 8; eeee eeeeeeee ee eeeeee eee eeeeeeeeee, eeee eeeeee eeee eeeeeeeeee eeeeee eeeeee eeeee ee eeeeeeee.

Meeeee 8 Meeeee Meeeeeeeeeee ee Meeeeeeeeeeee eeeeeee Meeeeeeeee Meeeeee Meeeeeeee eee Meeeeeeeeeeee[‌8‌,‌8‌]

Meeeeeee eeee eeeeeeeeee eee eeeeeeeeeeeeee eee ee ee e eeeeeee. Meeee, ee eeeeeeeeeee eeeeeeeeeee eee eeeeeeee, eeeee, eee eeeeee eeeeee ee e eeeeeeeeee eeeeeeeee eeeeeee ee eeeeeee eeeeeee. Meeeee, eeeeeeee eeeeeeeeee eeeeeeee eeeeeeeeee eeeeeeeee eeee e eeeeeeee eeeeee ee eee eeeeeee, ee ee eeee eeeeeeee eeeee ee eeeee eeeeeeeeee eeeeeee eeee eeeeee eeeeeeeee eeee eee eeeeee eeeee eeeeeeee, eeeeeeeeee eeeeeee eeeeeeeeee eeee eeeee ee eeee eee eeeeee eeeeeee eee eeeeeeee eeeeeeeeeee eeeeee. Meeeee, ee eeeeee ee eeee eeee eee M eeee ee e eeeee eeee ee eee eeeeeeee, eeeeeeeeee eeee M eeeee eeee ee eeeeee e eeeeeeeeeee eeeeeee ee ee eeeeeeee eeeeee eeee eeeeeeee eeeeeeeeee, eeeeeeeee, eee eeeeeee eeee eeeee eeeeeeeee eeeee eeeeeeeee eeeeeeee eee eeeee eeeee eeee eeeeee-eeee eeeeeeeeee eee eeeeeeeee. Meeeeee, ee eeee ee eeeeeee eee eeee M eeeee eeeeee ee eeeee eee eeeeee ee M eee eeee ee eeeee eeee eeee.

Mee eeeeeeeee ee eeeee eee eeeeeee eee eee Meeeeee ee Meeeeeeee Meeeeeeee Meeeeee ee ee eeeeeeeeeee eeee eeee eeeee ee eeeeeeee eeeeeeee ee eee eeeee, eeeeeeee, eee eeeeeeeee ee eeeeee eeeeeeeee, eeeeeeeeeeee eee eeeeeee eeeee ee eee eee ee eeeeeeee eee eeeeee eee eeeeeeeee eee eeeee eeeeee eee eeeeeee, eeeee eeee eeeeeeeeeee eeeeeeeee eee eeeeee eeeeeeeeeeee. Meee eee eeeeeee ee e eeeeeeeeeee eeeee ee eeeee-eeeee eeeeeee eee eeee eeeeeeeeeee eeeee eeee eee eeeeee ee eeee eeee, M ee eeeeeeeee eeee eeee eeee eee eeee eeeeeeee. Meeeee eeeee eeeeeeeee eeeeeee eee eeeeeeeeee eeee eeeee ee eee eeeeeee (eee eeeee eee eeee, eee eeeee ee eeeeeee ee eeeeeeeeeee eeee ee eeee eeee; eee eeeeeee eee eeeeeeeeeee eeeee eee eeeee ee eee eeeeeeeeee eeeeeeeeee eeeeeeee), e eeeeeeeee eeeeeeeeeeee eeeeeeeee eee eeeeee eeeeeeeee eee eeee eeeeee eee eeeee eeeeeee eeeee ee eee eeeeeeee eeee eeee eeeeeeeee eee eeeeeeee. Me eeee eeeee, eeee ee e eeeeeeee eeeeeee eeee ee eee Meeee–Meeee eeeeeeee, eeeee ee eeeee eeeeeeee ee ee e eeeeeeee eeeeeee eeeeeeeeeeee, eee eeeeeee eeeeeeee eeeeeeeee eeeeeeeee ee eeee. Meee eee eeeeeeee ee ee eeeeeeeee eee ee eeeeeee eee eeeeeeee eeeeeeeeee. Me eeeeeeee, eeeeeee eee eeeeeeeeeeee eeee eeeeeeee eeee eee eeee eeeeeeeeeeeeee eeeeeeee eeeee eeee eeeeeeeeeeee eeeeeeeeee eee eeeeeeeee eeee eeee eeee eeeeeeeeee, eeeeee eeee eeeeeee ee ee eeeeeeeeeeeee, eee eeeeeee eee ee eeeeeeee eeeeeeeeeee eee eeeeeeeeee eeee eeee eeeeeeee eeeeeeeeee.

Mee eeeee eeeeee eeeee eeee eeeeeee eeeeeeeeeeee, e eeeeeee eeeeee eeeeeeee eeeeee eeee eeee eeee e eeeeeee ee eee eeeeeeeeee eeeee eeeeeeee ee eee Meeee–Meeeeeeeeee eeeeeeeeee, eeeee eeee eeee eeeeeeee eee-eeee ee eee eeeeeee eeeeeee. Me e eeeeeee eeeeeeeeeeee ee Meeeee eee Mee (Meeeeee 8.8), eee eeee ee e eeeee eeeee ee eee eeeeeee ee eee eeeeeeee eeeeeeee eeee eeeeeee eeeeeee eeeeeeeeeeeeeee, eee eee eeeeeeee ee eeeeeeee ee eeee eeeee ee eeee eeeeeee ee eee eeeeeeeee ee eeeee eeeeeeee, eeee ee eee Meeee eeeeeʼe eee ee eeeeee(MMM) eeeeeee ee eeeeeeee eeeeeeee eeeeeee eee eeeeee eeeeeeeee eeeeee eeee eeeeeeeeeeeee, ee eeeee ee eee eeeeeeeeee ee 8 eeee 8 (Meeeee 8).[‌8‌]

Meeeee 8 Meeeee(MMM) Meeeeee Meeeeeeee Meeeeee Meeeeeeeeee Meeeeeeee ee Meeeee[‌8‌]

Me eee eeee eeee eeeeeee, ee eeeeeeeee eeeeeeeeeeee ee Meeeeee, Meeeeee, Meeeee, Meeeeeee, eee Meeeeeee (Meeeeee 8.8) eeeee eee eeeee eeeee eeeeeeee eee eeeeeeeee eeee eeeeeeeeeeee, eeeeeeeeeee eeeeeeeeee eee eeeeee eeeeeeeee eeeeeee eeeeeeee eeeee eee eeeee ee eee eeeeeeee Meeeeeeee eeeeeeeeee eee eee eeeeeeeee ee eeeeeeeeeee eee eeeeeee eeeeeee. Mee eeeeeee ee eeee e eeeeeeee eeeeeeee ee eeeee ee Meeeee 8.[‌8‌] Meeeeeee eeeeeeee eeeeeeeeee, eeeeeee eeeeeeeee eeeeee, eee eeeeeeeee ee eee eeeeeeee eeeeeee eeeeeeeeee eeeee eeeeeeeee ee eee eeeeeeeeee eeeeeeee eeee eeee eeee eeeeeeee ee eeee, ee eeee eeeeeee eeeeeeeeeee eeeeeeeeeee.

Meeeee 8 Me Meeeeee-Meeeeee Meeeee Meeeeeee Me Meee ee Meeeeee[‌8‌]

Meee, eeeeeeeeeeeeeee eeeeeeeee ee eeeeeeeeee eeeeee eee eeeeeeeee, eeee ee eeeeeeeee eeeeeee ee Mee eee M'Meeeee eeeeeeeeeeee eeeeeee eeee eeee eeeeeee eee eeeeeee eee ee eeeeeeeeeee ee eeeee e eeeeeee ee eeeeeee eeeeeeeee, eeeeeeeeeeee eeeeeee eeeeeeee (Meeeeee 8.8.8). Meeee eeeeeeee eeeeeeee eeeeeeee eeeeeeeeeee eeeeeeee ee eeeeeee eeeeeeee, eeeeeeeeeee eeee eeeeeee eeeeeeeee eee eeeee eeeee eeeeeee eeeeeee eee eeeeee ee eeeeeee eeee eeeeee eeeeeeeee. Me eee eeeeeeeee eeeeeeeeeeee ee Meeee eee Meeeee (Meeeeee 8.8.8), eee eeeeeeeee ee eeeeeeeeee eeeeeeeee ee eeeeeeee eeeeeeeeee eeeeeeeeee eeee eeeeeeeeee eeeeeeeeee eee eee eeeeeeeeeee ee eeeeee eeeeeeeee. Mee eeeeeeeeeeee eeeeeeeeeee eee eeeeeee eeeeeee eeeee eee Meeee eeeeeee ee eeeeeeeeeee ee Meeeee 8.[‌8‌] Meee, eeee-eeeeeee eeeeeeeeee ee e eeeeeeee eeeeee eeeeee eeeeeee 8 eeee eee eeeee eee eeeeeeeeeee eeee e eeeeeeeeeee eeeeeeee eeee eeeeeee e eeeeee eeeeeeee, eeee-eeeeeeee eeee ee eeeee ee eeeeeeeeee.

Meeeee 8 M Meeeee Meee-Meeeeee Meeeeeeeee/Meeeeeee Meeeeeeeeee Meeeeeee[‌8‌]

Me eeee eeee ee ee eeeeee eeeeee eeee eeeee eeee e eeeeeee eeeeeeee. Me eeeeeeeeee eeeeeee eeee Meeeeee eee Me (Meeeeee 8.8.8) eeeee eeee eeeeeee ee eee eeeeee ee eeeeeeee ee eeeeeeee-eeeeeeeee eeeeeeeee ee eeeeeeeeeeeeee eeeeeeeee. Meeee eeeee eeeeee eeeeeee eeeeeeeee ee eeeeeeee eeeeeeee (Meeeee 8) eeeeeee e eee eeee eeee eeeeeeee eee eeee eeeeeeeee eeeeeeeee ee eeeeeeeee (e.e., eeee 8 ee 8),[‌8‌] eeee eee eeee ee eeeeeee ee eeeeeeeee eeeee ee eee eeeee ee eee eee ee eeee eeeeeeeee eeee.

Meeeee 8 Meeeee Meeeeeeeeeeeeeeee Meeeeeeee Meeeeeeee ee Meeeeeeee[‌8‌]

Mee eeeeeeee ee eeee eeeeeeeeeee eeeeeee eeeeeeeee (eeeeeeeeeeee eeeeeeeee eeeeee-eeeeeeee eeeeeeee) eeeeee, eeee eee eeeee eeee Meeeeeeeee, Meeeee, eee Meeeeee (Meeeeee 8.8.8) eee eee eeeeee eeee Meeeee (Meeeeee 8.8.8). Meeee eeeeeeeeeeeee eeeeeeeeeeee eeeee eeeeeeeeee eeeee ee eeee ee eeee eeeeee eeeeeeeeeeee eeee ee eeeeeeeeee-eeeee eeeeeee eeeeeeeee. Meee eeee eeeee eee eeee eeeee ee eeeeeeeeee eee eeeeeeeee eeeeeee eee eeeee eeee ee eeeeeeee eee eeee eeeee- eee eeeeeeeeeeeeee eeeeeeee ee eeeeeee-eeeee eeeeee eeeeeeeee, eeeeeee eee eeee ee eeeeeeeeeeee, eeeeeeeeeeeeee, eee/ee eeeeeeeeeeeeee.

Meeeee 8 eeee eeeeeeeee eeee eee eeeeeeeeeeee ee eeee eeeee, eee-eeeeeee-eeeee, eeeeee eeeeeeeeeeeeeee, eeeeeeee eeee eeeeeeee eeeeeeeeeeeeee. Meee eeeeeeeee eeeeeeee e eeeeeee ee eeeeeeee eeeeeeeee, ee eeee eee eeeeee ee eeee eeeeeeeeeeee, eeee eeeeeeeeee, eeee eeeeeeee, ee eeeeeeeeeeeeee, eeeeee eeee eee ee eeeee eee, ee eeeeee, ee eeeeeeee ee eeee eeeeeeeee eeeeeeee. Meee, Meeeeee eee Mee-Meeeeeeee eeeeeeeeeee eeee eee eeeeeeeeeee ee eeee eeee ee eeeeee eeeeeeeee ee eeeeeeee ee eeeeee eeeeeeeee ee eeeeee eeeee eee eeeee (Meeeeee 8.8.8). Mee eeeeeeeee eeeeeee ee Me, Meee, eee Meee (Meeeeee 8.8.8) eeee eeeeeeee eeeeeeeee eeee Meeee eeeee eee eeeee eee eeeeeee eeeeeeeeeeeee eee/ee eeeeee eeeeeeeeeeeee eee eeeeeee eeeeeeeee. Mee eeeee ee eeeeeeeee eeeeeee ee eeeee eee eeeeeeee ee eeeee eeeeeeeeee, eee eee eeeeeeeeee eeeee eeeeee eeeeee eeeeeeeee eeeeeee e eeeeee ee eeeeee eeeeeee, ee ee ee eee eeee ee eeeeeeeeeeeeeee eeee ee eeeeeeeeeee eeeeeeeeeeeeee ee Meeeeeeee eeeeeeeee, ee eee eeeeee eeeee eeeeeeeee eeee eee eeeeeee eeee eee eeeee eeeee ee eeeeeeeee. M eeeee eee eeeeeeeeeeeee eeeeeeeeeeee eeee Meeeeeeeee, Meeee, eee Meeeeee (Meeeeee 8.8.8) eeee eeeeeee e eeeee ee eee eeeee ee eeeeeee ee eeeeee eeee eeeeeeeee, eeeeeeeeeeee eeeee Meeee-eeeeeeeeeeeee-eeee eeeeeeeee. Mee eeeeeee eeee eeeee eeeeeee, eeee ee eee Meeee eeeee eeeeeeeee ee eeeeeeeee M,[‌8‌] ee eeeee ee Meeeee 8. Meee, eeeeeeeee eeeeeeeeeeee 8,8-Meeee eeeeeeeeeeeeee (e.e., eeeee eeeee eeeeeeeee) eeeee eeeeeee, ee eeeee eeeee, ee eeeeeee eee eee eeeeee eeeeeee ee eeeeeeeee 8 eeee eeeeeeeeeee eee eeeee eeee ee eee eeeeee eeeeeeee.

Meeeee 8 8,8-Meeee Meeeeeeeeeeeee ee e Meeee Meeeeeeee ee Meeeeeeee M[‌8‌]

Meeeee 8 eeee eeeeeeeee eeee eeee eeeeeeee eeeeeee ee eeeee-eeeeeeee eeeeee eeeeeeeee (eeeeeeeee eeeee eeeee eeeee eee eeeeee eee eeeeeeee eeeeee ee Meeee eeeee, ee eeeee eeeee eee eeeeeee eeeeeee ee eee eeeeee, ee eeeeeee eeeeeeeee). Meee, eee eeeeee ee eeeeeee ee e eeeee-eeeee eeeeee ee eeeeeeeeeeeee eeee eeeeeee eeeeeeeeeeeee. Me eeee eeee eeeeeeeee-eeeeeeeee eeeeeeeee, eeeee Meeeeeee eee eeeeeeee ee eeeeeeeee eeeeeeeeee ee eeeeee eeeeeeeee eeee eee eeeeeeee eeee eee eeeee eeeee eee eeeeeeee eeeeeeee eeeeeeeeee (Meeeeee 8.8.8). Mee eeeeeee eeeee ee eee eeeeeee ee eeeee ee Meeeee 8;[‌8‌] eeee eeee, eeee eee Meeeee eeeee, eeeeeeeeee eeeeeeeeeee eee eeeee ee eeeee, eeeee, eee eeeeeeeee eeee eee eeeeeeeeee eeee eeeeeeeeee ee eeeeeeeee eee ee ee ee eeeeeeeeeeee eeee eeeeeee eeeeeeeeee.

Meeeee 8 Meeeeeeee-Meeeeeeee Meeeee Meeeeeee Me Meeee ee MM-88[‌8‌]

Meee ee e eeeeeee ee Meeee, Meeeee, eee Me ee eeeeeee-eeeeeeee eeeeee eeeeeeeee (Meeeeee 8.8.8). M eeeeeeeeeeeeee eeee eee ee eeeee eee eeeeeee ee eeeeeeeee eeee ee Meeeee 8,[‌88‌] eeeee eeeeeeeeee, ee eeeeeeeeee, eee eeeee ee eeeeeee ee eeeeeee eeeeeeee eeeeeeee eeee eee eeeeee e eeeee ee eeeeeeeee, ee eeee eeee eee eeeeeeeee ee eeeee eeeeeeeeeee eeeee 8. Meee-eeeeeee, eeeeeeee, eee eeeeeeeeeee eeeeeeee eeee eeeeee ee eeee eeeeeeeee (Meeeee, Meeeee, eee Meeeeeee; Meeeeee 8.8.8), eeee eeeee eeeee eeeeeeeee (Meeeeee; Meeeeee 8.8.8), eee eeeeee eeeeeeeee (Meee eee Mee; Meeeeee 8.8.8). Meeee eeeeeeeeeeeee eeeeeeeeeeee eeeeeeeee eee eeeeeee eee eeeeeeeee eeeeeeeee eeee ee Meeee-eee eeeeeeeee eee Meeeee–Meeee eeeeeeeee eee ee eeeeeeeeeee eeeeeeeeeeee ee eeee eeeeeeeee eeeeee ee eeeeeee eeeee eeeeeeeee eeeeeeeeee ee eeeeee eeeeeeeeeee eeeeeeee.

Meeeee 8 Meeeeee-Meeeeeeee Meeeee Meeeeeee Meeeeeeee Meeeeee/Meeeee Meeeeeeeee eee Meeeeeee Meeee Meeeeeeee[‌88‌]

Meeeee 8 eeeeee eeee eeeeeeee ee eeeeee eeeeeeeee eeee eee eeeeeee ee eeeeeeeeee eeeeeeeee. Me eee eeeeeeee eeee ee eeeeeee eeeeee eeeeeeeee, eeeeeeeeee eeeeeeeee ee eee eeeee eeeee, ee ee Meeee–Meeee eeeeeeeee, Meee eeeeeeeeeeeeee, eeeeeeeeeeeeeeeeeee, eee eeeeeeeee, eee., eeee eeeeeee eeeeeeee eeee ee eee eeee eeeeeee eeeeee eee eeeeeeee eeeeeeeeee ee eeeeeee eeeee eeeeeeeee eeeeeeeeee; eeeee eeeee eeeeee eeeeeeeee eee eeee ee eeeeeeeeee eeee eeeeeeeeeeeee. Mee eeee eeeeeeee ee eeee eeeeeee eee, eeee eeeee ee Meeeee 8, eeeeeeee eeeee ee eee eeeeeeeeee eeeee, eeee eee eeeeeee eeeeeeeeeeee ee Meeeeeee eee Meee (Meeeeee 8.8.8) eeeeeeeeee eeeeee eeeeee eeee eeeeeeee eeee eee Meeee–Meeee eeeeeeee. Mee eeeeeee eeee eeeee eeeeeeeee eeeeeeeeeeee ee eeeee eeeee ee Meeeee 8,[‌88‌] eeeeeeeeeeee eee e eeeeee Meeee–Meeee eeeeeeee/eeeee-Meeee–Meeee eeeeeeee eeeeeeeee ee eeeeee eeeeeeeeee eee e eeeeee eeeee ee eee eeee ee 88 eeeee eeee ee eee “eeee” eeeeeeee eeee eeeeee ee eeeeeeee e eeeee eeeeeeeee ee eeeeeeeee M.

Meeeee 8 Meeee–Meeee/Meeee-Meeee–Meeee Meeeee Meeeeeee eee Meeeeeeee M[‌88‌]

Mee eeeeeeeeee eeeeeee eeee Meeeeee eee Meeeee (Meeeeee 8.8.8) eeeeeeeeeee eeeeeeeeeee eee eeeee ee eeeeee eeeeeeeeeeeee eeeeeee eeeeeee [8 + 8], [8 + 8], eee [8 + 8] eeeeeeeeeeeeee, eee eeeee eeeeeee eeeeeeeee eeee eee eee ee e Meeee–Meeee-eeee. Me eeee eeee eeee eeeeeeeeeeeee eeee eeeeeeeeeeeee eee eeee eeeeeeee ee e eeee-eeeeeee-eee eeeeeee eeee Meeeeee, Meeee, Meeee, eee Meeeeee (Meeeeee 8.8.8). Mee eeeeeee eeeeeeeee eeeee, e eeeeee 8π-eeeeeeeeeeeeeeeeee/Meeee–Meeee eeeeeeee eeee eeeeeee e Meeeee eeeeeeee eeeeeee 88 eee 88, ee eeeee ee Meeeee 88;[‌88‌] eeee eeeee eeeeeeee eee eeeee-eeee eeeeee ee 88 eee e eeeeeee eeee eeeee ee eeeeeee ee Meeeeeʼe eeeeeeeeeeee ee eee eeeeee MM-8888; ee ee eeeeeee eeee eeee e eeeeee eeeeeeeeeeee eeeeeee eeee eeee eeeeeeeeee eeeeee eeeeeeee. Meee eeeeeee eeeee eeeeee eeee eeee eee eeee eee eeeeeeeee eeeeeee, eee eee eeeeeeeeee ee eee eeeeeeeeeeeeeeeeee eeeeeee ee eeeee ee eeeee eeeeeeee ee eee eeeeeee eeeeeeeee eeee ee eee eeee eeeeeeee eeee e eeeeeeee eeeeeeeeeee. Meeeeee, eeee-eeeeee eee eeeeeeeeee eeeeeeeee eeeeeeee eeee Meeeeeee eee Meeeeee ee eeeeeeeeeee eeeeee eee eee eeeeeeeee (Meeeeee 8.8.8), eee eeee Meeeeeee ee [8,8]-eeeeeeeeeeeeee (e.e., Meee eee Meeeeee eeeeeeeee; Meeeeee 8.8.8) eeeee eee eeee eeeeeeeeee eeeeeeeeee ee eeeeee eeeeeeeee eeeeeeee.

Meeeee 88 Meeeee Meeeeeee/Meeeeeeeeeeeeeeeee/Meeee–Meeee Meeeee Meeeeeee eeeeee (−)-MM-8888[‌88‌]

Mee eeee eeeeeee eeeee eeee Meeee eee Meeee (Meeeeee 8.8) eee eeeeee eeeeeeee ee eee eeeeeeeeeeeeeee eeeeee ee eeee ee eeeeee eeeeeeeee, ee eeee ee eeeee eee eeee eeeeeeʼe eeeee eee eeee eeee eeeeeee. Me eeeeeee ee eeeee eeee ee eeeee ee Meeeee 88, eeee e eeeeee ee eeeeeeeeee eeeeeeeee eeeeeeeee eeeeeeeeee eeeeeeeeeeeeeeee eeeeeee ee e eeeeeeeeeeeeee eeee eeeeeeeee (88) ee eeeee eeeee ee eee eeeee eeeeeeeeee eee eeee. Meeeeeee eeeeee ee eeee eeeeeee eeee eee eeeeee eeeeeeee eeeeeee eeeeeeeeee eee eeee eeeeeee eeeeeeeeeeeeee.

Meeeee 88 Meeeeeeeee Meeeeeeeeeeeeee eee e Meeeee Meeeeeee[‌88‌]

Meeeeee, eee eeeeee eeeeee eee eeee eeeeee eeeeeeeee eeee eeeeeeee eeee eeeeeee eeeeeeee eeeeeeeee. Meeee eee Me eeeee eeeee eeeeeeeeeeeee eeee eeeeeeeee ee eeeeeeeeeeee eeeeeee (Meeeeee 8.8.8), eeeeeeee eeeeeeeeeeeeeee, eeeeeeeeeeeeeeeeeeee, eeeeeeeeeeeeeeeeeee, eee eeeeeeeeeeeeeeee ee eeeeeeeeee, eeeeeee ee eeee eeeee ee eeeee eee eeeeeeeee eee eeeeeeeeeee ee eee eeee. Mee eeeeeeeee eeeeeee, ee Meeee, Meeeeeeee, Meeee, eee Meeeee (Meeeeee 8.8.8), eeeeeee ee eeeeeeeee ee eeeeeeeee eeeeee eeeee, eeee ee Meeeeee eeeeeeeee, eeeeeee eeeeeeeee, eee eee eeeeeeeee ee eeee eeeeee ee eeeeeee eeeeee eeeeeeeeeeeeeee. Meee ee eee eeeeeeeeee eeee eeeeeee ee eee eee ee eeeeeee eeeeeeeee ee eeeeee eeee eeeeeeeee, eeee e eeeeeeeeeeee eeeeeeeeeee eee eeeeee eeeeeeeeee ee eee eeeee-eeeee eeeeeeeeee eeeeeeeee ee eeeeeeeee eeee ee 88M eee/ee 88M (Meeeee 88), eeeee eee eeeeeeeeeeee ee eeeeeeeee eeee eeeeee eeeee eeeeeee.[‌88‌‌88‌] Meeee eeee-eeeee eeeeeee eeeeeeeee ee eeee eeeeee eeeeeee eeeeee eeeeeeeeee eeeeeee (−)-eeeeeeeeeee (Meeeeee).

Meeeee 88 M Meeeeee/Meeee Meeeee Meeeeeee[‌88‌]

Mee eeee eeeeeee, ee Meee eee Meee, ee eeeeeeeee ee eeeeeeeee (Meeeeee 8.8.8) eeeeeeee eeeeeeeee eeeeeeeeee ee eee eeeeeeeeee ee eeeee eeeeeeee eeeeeee eeeeeeeee, eee eeeeeee ee eeeeeee eeeee eeeeeeeee, eeeee eeeee eeeee ee eeeeeeeee eeee ee Meeeeeee eeeeeeeee. Mee eeeee eeeeeee, eeee Möeeeee, Meeeeeee Meeeeeeee, Meeeeeeeeee, eee Meeee (Meeeeee 8.8.8), eeeee ee ee eeeeeeeee ee eeeeee–eeeeeeee eeeee ee eee eeee ee eeeeee, eeeeeeee, eee eeeeeee eeeeeeeeee eeeeee. Meeee eeeee eee eeeeeeee eeeeeeeee eeeeeeeee eeee eeeee eee eeee eeeeeee eeeeeee eeee eee ee eeee eeeeeee eeeeeeeeeee eeeeeeeee eeeeee eeeeeee eeee eeeeeeeeeee eeeeeeeeee eee eeee eeeeeeeeeeee eeeeee.

Me eeeeeeeeee, M eeee eee eeee eeee eeeee eeeeeee ee ee ee eeeeeeeeeee eee eeeeeeeeeee ee M eeee eeeee eeeeeee eeeee eeeee. Meee eeeeeeeeee eeeeeee e eeee-eee eeee eee eeeeeeeee eeeeee eeeeee eeeeeeeee ee eee eeee eeeeee ee eeeeeeeeee eeeeeeeeee eee eeeeeeee eeeeeeeee eeeeeeeeee, eee M eeee eee eeee eeee eeeeeeeeeee eeeeee eeeee eeeee, eeeeeee eeee eeee ee eee eeeeeeeee eeeeeeeeeee, eeeeee eeeeeeeeeeee, ee eee eeeeeeeeeee ee eeeeeeeeeeee eeeeee eeeeee ee eeee-eeeee eeeeeeeee. Mee eeee ee eeeeeee eee eeeeeeeee eee ee eeeeeee eeeeeeee ee eeeee; ee ee eee eee, eee eeeeee, ee eee ee eeee (eeeeeee ee eee eeeee ee eee eeee ee eee eeeee) eee/ee eeeeeeeee eeee ee eeee eeee eeee eeeeeeeee eeeeeee eee eeeeeeeeee eeeeeeeeeeee.