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1.3.1.3.2.1 Double Ring-Closing Metathesis with Dienynes

DOI: 10.1055/sos-SD-219-00067

Lee, D.; O'Connor, M.Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (2015199.

The prowess of enyne metathesis for the construction of multiply fused cyclic frameworks containing conjugated unsaturation is most clearly illustrated in the domino double ring-closing metathesis of dienynes containing appropriate tethers between the alkyne and alkenes (Table 2, entry 8).

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Meeeee 88 Meeeeeeee ee eee Meeeeeeeee Meeeeeeee[‌888‌]

Meeeeeeeeeee Meeeeeeee

(8M,8M,8M,8M,88M)-88-[8-(8,8-Meeeeeeeeeeee)-8,8-eeeeeee-8-ee]-8,88-eeeeeeeee-8-eeeeeeeeeeee-8,8-eeeeee Meeeeeee (888); Meeeeee Meeeeeeee eee Meeeee Meee-Meeeeee Meeeeeeeee eeee Meeeeeee:[‌88‌]

M eeee ee eeeeeee 888 (88 ee, 8.88 eeee) ee eee 8,8-eeeeeeeeeeeeee (8 eM) ee e Meeeeee eeee eee eeeeeeee eeeee eeeeee ee eee eeeeee–eeee–eeee eeeeee, eee eeeeeee eeee Meeeee eeeeee-eeeeeeeeee eeeeeeeee 8 (8.8 ee, 8.88 eeee). Mee eeeeeee eee eeee eeeeee ee 88–88 °M eee 8 e, eeeeeeee ee eeeeeee ee ee eee eeeeeeeeeeeee eeeee eeeeeee eeeeeeee. Mee eeeeeee eee eeeeeeee eeeeeee e eeeee eeee ee eeeeee eee (MeMMe/eeeeeee 8:8) ee eeeeee e eeeeeee ee eee eeeeeeee eeeeeeee, eeeeeeeeee eeeeeeee, eee eeeeeeeee eeeeeeeeeee eeeeeee. Meee eeeeeee ee MMM (8 eM) eee eeeeeeeee ee e eeee ee 8 M MMMM ee MMM (8.8 eM, 8.8 eeee) eee eeeeeeee eee 8–8 e. Mee eeeeeee eee eeeeee ee ee eee eeee eeeeeeeeeeee, eee eee eeeeeee eee eeeeeeeee ee eeeeee eeeeeeeeeeeeee (MeMMe/eeeeeee 88:88 ee 88:88) ee eeeeee eee eeeeeee ee e eeeeee eee; eeeee: 88.8 ee (88%).

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