Science of Synthesis

Wang, S.-H.; Tu, Y.-Q.; Tang, M., Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (2015) 1, 305.

In some cases, a domino process initiated by an epoxide ring-opening step can also be terminated by a pericyclic reaction, a process which is arguably the most popular way to form a ring-closure product. One significant advantage of pericyclic reactions over more standard cationic cyclizations is greater functional group tolerance, meaning that this type of domino reaction is highly practical for the synthesis of molecules with complex architectures.

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References