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1.5.2.3.1.2.1 Termination with a Nucleophile

DOI: 10.1055/sos-SD-219-00174

Wang, S.-H.; Tu, Y.-Q.; Tang, M.Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (20151307.

The most common way to terminate a domino cyclization initiated by a carbonyl or its derivatives is through the use of a nucleophile. Johnson and Kinnel first reported acetal-initiated cationic polyene cyclization.[‌86‌] Since their pioneering work, such reactions have been further developed for the efficient construction of polycycles.

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References