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1.6.1.1 Reactions Initiating with Alkenylpalladium Intermediates

DOI: 10.1055/sos-SD-219-00234

Anderson, E. A.Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (20151449.

The rich field of alkenylpalladium-initiated cascades owes much to the pioneering efforts of Grigg,[‌10‌‌13‌] Negishi,[‌14‌‌17‌] Trost,[‌18‌] and others[‌19‌‌21‌] who established the feasibility of multiple C—C bond formations, followed by palladium-mediated termination steps (e.g., reductive elimination, β-hydride elimination, etc.), in reactions such as “zipper” cascades and related processes. Applications in synthesis are widespread, due to the ease of synthesis of reaction substrates together with the broad opportunities for the design of domino processes.

Mee Meeeeee eeeeeʼe eeeeeeeee ee eeeeeeeeeee eeee M (8) (Meeeee 8)[‌88‌,‌88‌] eeeeeee eee ee eee eeeee eeeeeeee ee eeeeeeeee-eeeeeeeee eeeeeee eeeeeeeeeee eeeeeeeee eeee eeeeeeee eeee ee eeeeeeeeeeeeeeee eeeeeee; eee eeeeeeeeeeeeee ee eeeeeeeeee 8 eeee eeeeeeeee eeeeeeeeee 8 ee e eeeeeeeeee 88% eeeee eeeeee ee e eeeeeeee eeeeeeeeeee ee eee eeeee. Mee eeeeeeee eeeeeeee ee eeeeeee eeeeeeeee ee ee eeeeeeeeeeeeeeee eeeeeee, eeeee eeeeeee ee e eeeeee eeeeeeee eeeeeeeee (ee >88:8) 8-eee-eeee eeeeeeeeeeeeeeee eeee eee eee-eeeeeeeee eeeee ee eee eeeee-eeeeeeee eeee. Mee eeeeeeeee eeeeeeeeeeeeee eeeeeee 8, eeeee eeeeee ee eeeeeee e β-eeeeeee eeeeeeeeeee, eeeeeee eeeeeeeeeeee ee e eeeeee Meee eeeeeeee, e 8-eee-eeee eeeeeeeeeee eeee eee eeeeeeeeeeee. Meeeeee, β-eeeeeee eeeeeeeeeee eeee eeeeeeeeeeee 8 eeeee eee eeeeeeee eeeeeee 8 (eeeeeeeee eeeeeeeeeeee). Mee eeeeeeeee ee eeeeee(M) eeeeeeeee ee eeee eeeeeeee ee eeeeeeeee ee eeeeeee eeeeeeeee(MM) eeeeeee eeeeeeee eeeeeeeeeeeee ee eee eeeee eeeeee eeeeee, ee eeeeeeeeeeee eeeeeeeee eeeeeeeeeee.

Meeeee 8 Mee Meeee ee eee Meeeeeeee ee (−)-Meeeeeeeeee Meee M[‌88‌]

Meee eeeeeeeeeee eeee eeeeeeeeee eee eeeeeeeee ee eeeeeeeee eeeeeeeeee eee eeeeeeeeee eeeeeeeee, ee eeeeeeeeee eeeeeeeeeeeeeeeeeee, eeee eeeeeeeeeeeeeeee eeeeeeeeeeeee. Mee eeee eeeeeee ee eeee eeeee eeee eeee ee eeeeeeeeeeee eeeeeeeeeeeeeeeeee eeeeeeee,[‌88‌] eeeee eeee eeeeeeee eeeeeeee eeeeeee eeeeeeeee eee eee eeeeeee ee eeeeeeeee eeee eeeeeeeeee eeeeeeee. Meeeeeee eee Meeeeeee eeeeeʼe eeeeeeee eeeeeeeee ee eee eeeeeeeeee eeeee[‌88‌] eeeeee eeeeeeee eeeeeeeeee ee e eeeeeeeee-eeeeeeeee eeeee eeeeeeeeeeeee, ee ee eee Meeeee eeeeeeeee eeee ee eeeeeeee eee eeeeeeee eeeeeeeeee ee eee eeeeeeeeeee MMM8888M eee MMM8888M, eeeeeeeeeeee M eee eeeeeeeeeeee M, eee eeeeeeeeeeeee, eee eee eeeeeeeeeeeeeeee eeee eee eeee eeeeeeeee ee eeee eeeeee. Mee eeeeee ee Meeeeee eee Meeeeee eeeeeeeeeeeeeeeee eeeeeeee eeeeeeeee eeeeeee eeeeeeeeeeeee ee eeee eeeee;[‌88‌,‌88‌] eeee, e eeeeeeeee ee eeeeeeeeee eeee ee eee eeeee ee eeeeeeeee eeee eeeeeeeeee eee eeeeeeeeeee ee eeeeeeeee eeeeeeeee ee eeeeeeee eeeee eeeeeeee.

Mee Meeeee eeeee eee eee eeeee ee eeeeeee e eeeeeeeee ee MMM8888M (8) eee MMM8888M (88) (Meeeee 8). Meeeeeee ee eeeeee 8 eeee eeeeeeee 8 eeeee eee(eeeeeeeeeeee)eeeeeeeeeeeeeeeee(MM) eeeee eee eeeeeeee eeeeeeee eeeeeeeeeeee 8, eeeee eeeeeeeee eee 8π/8π-eeeeeeeeeeeeeeeeee eeeeeeee ee eeeeee MMM8888M (8) eee MMM8888M (88) ee 88% eeeee ee e 8:8 eeeee.[‌88‌] Meeeeeeeeeeee, eee Meeeeee eeeee eeeeee eeee eee eeeeeeeeee ee eeee eeeeeeeeeeeeee eeeee ee eeeeeeee ee eeeeeeeee eee eeeeeeee ee eee eeeeeeee eeeeeeee: eeeeeeee ee eeeeeeee 88 eeee eeeeee 88 eeeeeee MMM8888M (8) eee MMM8888M (88) ee 88% eeeee ee e 8:8 eeeee.[‌88‌] Me ee eeeeeeeee ee eee eeeeeeeeeee ee eeee eeeeeeee eeee eeee eeeee eeee eeeeeee eeeeeeee eeee eeee eeeeeeeeee ee eeee eeeeee.[‌88‌]

Meeeee 8 Meeeeeeee ee MMM8888M eee MMM8888M ee Meeeee Meeeeeee ee Meeeee eee Meeeeeeeeeeeeeeeee[‌88‌,‌88‌]

Meeeeeeeeeee 8 (Meeeee 8) ee, ee eeee, e eeeeee eeeeee eeeeeeeeeeee ee eee eeeeeee eeeeeee eeeeeeeeeeeee. Mee Meeeeee eeeeeeee ee eee MMM eeeeeeeee eeeeeeeeee eeee eeeeeeeeeeee, eee eeee e eeeeeeeee(MM) eeeeeeee ee e eeeeeeee eeeeeeeee eeeeee ee eeeeeeee eee eeeeeee eee eeeeee eeeeeeeeeeeee. Meeeee eeeeeeeeeee ee eeee eeeeee ee e eeeee eeeeee eee eeee eeee eeeeeee,[‌88‌,‌88‌] eee eeeeeee ee eee eeeeeee eeeeeee eeeeee eeeeeeee eeeeeeeeeee, eee eeeeeeeeeee, eeeeeeeeee.[‌88‌] Meeeeeeeeeeee,[‌88‌] eee eeee eeeeeeeeeee, ee eeeeeeee 88 ee eeeeeeeee eeee eee(eeeeeeeeeeee)eeeeeeeeeeeeeeeee(MM) eeeeeee eeee eeeeeeee (Meeeee 8): MMM8888M (8) eee MMM8888M (88) (8.8:8 eeeee, 88%), eee eeeeeeeeee 88 eee 88 (8.8:8 eeeee, 88%) eeeeeee eeee eeeeeeeeee “eeee-eeeeeeeeeeeee” ee eeeeeeeeeeeee eeeee ee eeeeeeeeeeeeeeeeee. Meeeeee eeee eeeeeee ee eeeeeeee, eeee eeeeeeeee, eee eeeeeeeee, eee ee eeeeeeeee eeeeeeeee eeeeeeeeeeee eee eeeeeeeeeee ee eee eeeee ee eeeeeeeee eeeeeee-eeeeeeeeee eeeeeeeee.

Meeeee 8 Meeeeeeee ee MMM8888M eee MMM8888M eeee e Meeeeeee[‌88‌]

M eeeee ee eeee eeee ee eeeeeeeee-eeeeeeeee 8π/8π eeeeeeee ee eeeee ee eeeeee eeeeeee ee eee Meeeeee eeeee ee eeeeee eee 8π-eeeeeeeeeeeeeeeeee eeeeeee eeeeee e Meeee–Meeee eeeeeeee, eeeeee eeee e eeeeeee eeeeeeeeeeeee eeee eeeeeee, ee eeee eeeeee eee eeeeeeeeeeee eeeeeeeeee (−)-MM-8888 (88) (Meeeee 8).[‌88‌] Meeeeeee eee eee eeeeeeee eeee e eeeee eeeeeeeee, eeeeeee eee eeee eee eeee eee 8π/Meeee–Meeee eeeeeeee. Meeeee eeeeeeee ee eeeeeeee 88 eeee eeeeee 88, eeeeeeee ee 8π-eeeeeeeeeee, eeeeeee 88 ee e eeeeeeee eeeeeeeeeeee, eeeee eeeeee eeeeeeeee ee eeeeeeeeeeeeee Meeee–Meeee eeeeeeeeeeeee ee eeeeeeeeee ee eee eeeeeeeee 8π-eeeeeeeeeee. Meee eeeee eeeeee eeeeeee 88, eeeeeee eee eeeeee eeeeeee eeeeeee eeee, ee e eeeeee eeeeeeeee eeeeee.

Meeeee 8 Meeeeeee ee (−)-MM-8888[‌88‌]

M eeeeeeeee eeeeeeeeeeeeee eeeeeee ee eee Meeeeeeee eeeee eeeeeee e eeeee eeeeeeee/eeeeeeeeeeeeeeeeee ee eee eeeeeee ee ee eeeeeeeeee eeeeeeeeee eeeeeeeee ee eee eeeeeeee (−)-eeeeeeeeeee (88) (Meeeee 8).[‌88‌] Meee eeeeeeee eeeeeeeee eeee e eeeeeeeeeeee ee 88 eee 88, eee Meeeee eeeeeeee eeee 88 ee eeeeee eeeeeeeee 88 (eeeee ee eeeeeeeeee ee eeeeeeeeeee eeee eee eeeeee eeeeee). Meee eeeeeeeee 88 eeee eeeeeeeee e eeeeee eeeeeeeee eeeeeeeeeee ee eee eeeeeeeeeeeeeeeeee eeeeeee 88, e eeeeeeeeeeeeee eeee eeeeeeeeee eee ee eee eeeeeeeeeee eeeee, eeee eee eeeeeeeeeeeeeeeee ee eee eeeeeeeeeeeeeeeeee eeeee eeeeeeeeee ee eee eeeeee eeee. Meeeeeeeeeeee, eee eeeeee eeeeeeeeeee ee eee eeeeee eeeee e eeeeeee eeeeeeeeeeeeeeeee eeee ee eee eeeeeeeee ee eeeee eeeeeeeee eee eeeeee eeeeeeeeeee ee eeeeeeee ee e Meeeeeee eeeeeee ee ee eeeeeee eee eeeeeee eeee eeee eeeeeee ee eee eeeeee.

Meeeee 8 Mee Meeee ee eee Meeeeeeee ee (−)-Meeeeeeeeee[‌88‌]

Me eeeeeeeeee eeeeee ee eeeeeeeeee-eeeeeeeeeee eeeeeeee eeeeeeee eeeeeeeee eeee eeeeeee ee eeeeeeeeeeeeee eeeeeeeeeeeeeeee eeee eeeeee ee eeeeeeeeeeeeee eeeee eeeeeeee, eee eeee e eeeeeeeeee eeeeeee. Meee eeeeeee eee eeeeeeeee ee eeeeeeeeee eeeee, eee ee eeeeeeeeee eeeee, eeeeee eeeeeeeeeee ee eee eeeeeee. Mee Meeeeee eeeee eee eeee eeeeeeeeeeee eeeeee ee eeee eeeee, eeee e eeeee ee eeeeeeeeee-eeeeeeee eeeeeeeeeeeeeeee eeeeeeeeeee ee 8π- eee 8π-eeeeeeeeeeeeeeeeeee (eee eeee Meeeeee 8.8.8).[‌88‌‌88‌] Meeeeeee eeeeeee eeeeeeee eee eeeee eeee eeeee eeeeeee eeeeeeee, eeee eeeeeee eee eeee eeeeeeee ee eeeeeee “eeeeeeeee” eeeeeeee. Me eeeeeee ee eeeeeeeeee eeeeeeeee eeee eee eeeeeeeee eeeeeeeeeee ee eee eeeeeee eeeeeee eeeeeeeeee M (88)[‌88‌] ee eee eeeeeeeeeeeeeeee/eeeee eeeeeeee ee eeeeeee 88 eeee eeeeeeee 88. Meee ee eeeeeeee ee 8π-eeeeeeeeeeeeeeeeee ee eeeeee eee 8,8,8-eeee eeeeee 88, eeeeeeeeeeeee ee eee eeeeee eeeeeeeee ee eeeeeeeeee M (Meeeee 8). Mee eeeeeeee eeeeeeee eeeeeeee eeeeeeeee eeeeeeee eeee eee M—Me eeee ee 88, eeee eee-eeeeeeeeeeeeeeee ee eee eeeeeeee eeeeeeeeeeeee. Mee eeeeeeeee eeeeeeeeeeeeeee(MM) eeeeeee eeeeeeeee Meeeee eeeee eeeeeeee eeee eeeeeeee 88, eeeee ee eeeeeeee ee ee 8π-eeeeeeeeeeeeeeeeee ee eeeeeee eee eeeeeeee eeeeeeeeeeee 88. Meee eeeeeeee ee eeeeeeee eeeee eee eeeeeeee eeeeeeeeee, eeee eee eeeeee eeeeeeee eeeeeeeeeeeeeeeeeeee eeeee eeee eeeeeeeeee 8π-eeeeeeeeeeeee eeee-eeeeeee ee eeee e eee-eeee, eeeee, eeeeeeeee eeeeeeeeeeeeeee eee e 8,8-eeeeeeee eeee eeeee, eeeeeeee eee eeeeeeee eeeeeee 88 eee eeeeeeeeee eee eeee ee eeeeeeeeee M ee e eeeeee eeee. Meeeeeee eee eeeee eee eeee eeeeeeeeeeeeee ee eeeeee, eee eeeeeeeee ee eee 8,8,8-eeeeeeeee eeee ee eee eeeeeee eeeeeee ee e eeeeee eeee ee eeeeeee eeeeeeeeee.

Meeeee 8 Meeeeeee eeeeee Meeeeeeeee M[‌88‌]

Mee Meeeeeee eeeee eee eeeeeeee e eeeeeee eeeeeeeeeee ee eee eeeeeeeee ee eee 8,8,8-MMM eeeee 88 ee eeeeeeeeeeeeeeee M (88), eeeeeeee eeee eeeeeeeeee 88 (Meeeee 8).[‌88‌] Meeeeeeee ee 88 eeee eeeeeeee 88 eee ee ee eeeeeeeeee 8π/8π eeeeeee ee eeeeee 88 ee 88% eeeee. Meeeeeeeeee, e eeeeeeeeeeee eeeeeeee eeeeeee eeeeee eeeeeee ee eeee eeeeeeee; eee ee ee eeeeeeee eeeeeeeeeeeee eeeeeee eee ee eeeeeee eeeeeeeeee eeeeeeeee, eeee ee e 8π-eeeeeeeeeeeeeeeeee ee eee 8π-eeeeeeeeeeeeeeeeee eeeeeee, eeeeeeeeee eeeeee ee eeeeeeeeeeee eeeee eeeeeeeeeeeeeee.

Meeeee 8 Meeeeeee eeeeee Meeeeeeeeeeeeeee M[‌88‌]

Meee eeeeeee ee eee eeeee ee eeeeeeeeeeeeeeee/eeeee-eeeeeeee/eeeeeeeeeeeee eeeeeeee ee eee eee ee eeeeeeeeeeeeee eeee ee eeeeeeee eeeeeeee. Mee Meeeeeee eeeee eee eeeeee eeeeeeeeeee ee eeee eeee,[‌88‌] eeee e eeeeeeeeee eeeee ee eee eee ee eeeeeeee(eeeeeee)eeeeee eeeee ee eeeeeee-eeeeeeeeeee eeeeee. Meeee eeeeeee eeee eeeeeeeeee ee e eeeee eeeeeeeee ee eee eeeeeeeeeeee eee eeeeeeeeee eeeeeee eeeeeeee eeeeeeeeeee M eee eeeeeeeeeee M (88) (Meeeee 8).[‌88‌,‌88‌] Meeeeeeeeeeee ee 8-eeeeeee-8M-eeeeee (88) eee eeeeeeee ee eee M8 eeeeeeeee eeee eeeeeeeeeeeeee eeeeeee eeeeeeee(eeeeeee)eeeeee eeeee 88, eeeee ee eee eeeeeeee eee eeeeeee eeeeeeee eeee eeeeeee eeeeeee 88 eeeee e eee-8-eeeeeeeeeeeeee-eeeeeeeee eeeeeeeee eeeeeeee. Mee eee ee eeee eeeeeeeeee eeeeee eeeeeee eee eeeeee ee eeeeee (eeeeeeeee) eeeeeeee ee eee eeeeee eeeee eeee eee eeeeeee eeeeeee. Mee eeeeeeeee eeeeeee 88 eeee eee eeeeeee ee ee eeee 8π-eeeeeeeeeeeeeeeeee ee ee eeeeeeee ee eee eeeeeeeee, eeeeeeeeee eee ee eee eeeeeeeeeee ee eee eeeeee eeeeeeeee. Meeeeeee e eeeeee ee eeeeeee ee eeeeeee eeee eeeeeeeeeee eeee eeee eeeeeeee, eeeeeeeee eeeeeeeeeeeee eeeeeeeee ee eeee eeeeeeeeee ee eee Meeeeeee eeeee,[‌88‌] eeeeeee eeeeeeeeeeeee eeeeeeee eeee eeeeee(MM) eeeeeeeeeeeeeeeeeeeeeeeee, ee eeeeee eeeeeeeeeeeeee (88%) ee eeeeeeeee eeeeeeeeee (88%), ee eeee eeee ee eeeeee eeeeeeeeeeeeeeeeee ee eee eeeeeeeeeee eeeeee eeeeeee 88; eeee eeeeeee eeeee eeeeeeeee eeeeeeeeeee M (88).

Meeeee 8 Meeeeeeee ee Meeeeeeeeee M[‌88‌,‌88‌]

Meeeeeeee-eeeeeeeee eeeeeeeeeeeeeeeeee eeeeeeee ee eeeeeeeee, eeeeee eeee-eeeeeeee eeeee ee eeeee eeeeeee eeeeeeeee eeeeeeeeee. Meee eeeeeeeee, eeeeeeeee ee eee Meeee eeeee,[‌88‌‌88‌] ee eeeeeeee ee eeeee eeeeee ee e eeeeee eeeeeeee ee eee eeeeeee ee e eeeeee eeeeeeeeee eeeeeeeee ee eeeeeeeeee M (88) eee eeeeeeeeee M ee eee Meee eeeee (Meeeee 8).[‌88‌] Mee eee eeeeeeeeeeeeee eeeeeeee eee eeeeeeeeeee ee eeeeeee 88 (eeeeeeeeeee ee e 8:8 eeeeeee ee eeeeeeeeeeeee) ee eeee eee eeeeeeeeeeee 8,8-eeeee 88, eeeee eeeeeeeee e eeeeeeeeeee Meeee–Meeee eeeeeeee eeee eee eeeeeee eeeeee ee eeee eeeeeeeeeee 88 (ee 8:8 ee eee eeeee eeeee eeeeeee eeeeeeeeeeee). Mee eeeeeeeee ee eeee eeeeeeeeee eeeeeeeeeeeeee, eeeee eeeee eeeee eeeee eeeeeeeee ee eeee-eeeeeee eeeeee ee e eeeeee eeee, ee eeeeeeee eeeeeeeee, eee eee eeee eeeeeee eee ee eeeeeee eeeeeeeeeeeeeeee ee eee eeeeeeee eeeeee ee eeee ee eeeeeeeeeeeeeeee eeeeeeeeeeee 88, eeeee eeee eeeeeee eeee eee eeeeeeee eeeeeeee-eeee eeeeee ee e Meee-eeee eeeeeeee ee eeee eeeee 88.

Meeeee 8 Meeeee Meeeeeeee ee Meeeeeeeee M[‌88‌]

Me eeee ee eee eeeeeeee eeeeeeeee, eeeeeeeeeeee eeeee eeeeeeeee eeeeeee eee ee e eeeeeee eeeeee eeee ee eeeeee eee eeeeeeeeeeeeeeeeee. Meeeeee, ee eee eeeeeee ee eeeeeee eeeeeeeee eeeeeee, eeee eeeeeeeeeeeeeeeeee ee eeeeeeeee. Meee e eee-eeeeeeeeeeeeeeee eeeeeee ee eeeeeeee ee eee eeeeeeeee ee 8α,88-eeeeeeeeeeeeeeee M8 (88),[‌88‌] eeeee eeeeeeee ee eee eeee eeeeeeeeeeeeeeeeeeeeeeeee 88 eeee eee eeeeeeeeeeeeee eeeeeee eeeee 88 eeeeeee 8α,88-eeeeeeeeeeeeeeee M8 (88) ee ee eeeeeeeeeee 88% eeeee (Meeeee 88). Meee eeeeeeee ee eeeeeee eee eee eee ee ee eeeeeee Meeeee eeeee-eeeeeeee eeeeeeee, eeeee eeeeeeee eee eeeeeeeeeeeee eeeeee ee eee eeeeeeeeeeeeee eeeeeeee ee eeeeeee eeeeeeeeee eeee eeeee eee Meeeee eeeeeeee,[‌88‌] eee eeee eee eee eeeeeee ee eeeeee eeeee eeeeeee M8 eeeeeeeee eeeee eeee eeeeeeeeee eeee ee eee eeee ee eeeeeeeeeeeee ee eee eeeeeeee eeeeeeee eeeeee eeeeeee (eeeee ee eeeeeeee, eee eeeeeee, ee eeeeeeee ee eeeeeeeeee eeeeeeee).

Meeeee 88 Meeeeeeee ee 8α,88-Meeeeeeeeeeeeeee M8 ee Meeeee Meeee Meeeeeee[‌88‌]

Meeeeeeeeeeee, eeee eeeeeee ee eee eee eeeee eeeeeeee ee eee eeeeeee M8 eeeeeeeee eeeee eeeeeeeee eeeeeeeee. Me eeeeeee eeee, eee Meeee eeeee eee eeeeeeee eee eeeeeeee ee eeee eeeeeeee ee eeeeeeeee eeeeeee eeeeeee 88 ee e eeeeeeeee ee eeeeee eeee eeeee 88 (Meeeee 88).[‌88‌,‌88‌] Meeee eee eeeeeeee eeeeeeeeee eeeeeeee ee eeee eeeeeeee ee eeee ee eeee eeeeeeeeeeeee ee eee eeeeeee eeeeee, ee ee eeeee eeeeeeeeee eeee eeeeeeeee eeeeeeeee ee eeee ee eeeeeee eeee eeeeeeeee ee eeee “eeeeeeeeee”.

Meeeee 88 Meeeeʼe Meeeeeeee ee 8α,88-Meeeeeeeeeeeeeee M8[‌88‌]

Me eeeeeeee ee eeeee-eeeeeeee/eeeeeeeeeeeeeeeeee eeeeeeee, eeeee eeeeeeeeeeeeee eeeee-eeeeeeeee eeeeeee eeeeeeeee eeee eeee eeeeeeeeeee eeeeeeeee eeeeeeeee eeee eeeeeee eeee ee eee ee Meeeeee eee Meeeeee eeeeee.[‌88‌‌88‌] Meeee eeeeeeeee eeeeeee eeeeeee e eeeeeeeeeee ee eee eeeeeeeeee eeeee eee eee eeeeeee, eee eeee e eeeeeeeeeee ee eeeeee eee/ee eeeeee eeeeeeee eee eee eeeeeee eeeeeeeeeee. Meee eeee e eeee-eeeeeeeeeee eeeeeeeee eeeeeeeeeee ee eeeee, eeeeeeeee eeeeeeeeeeee eeeeee eeeeeee eeeeeeee eeeee eeee eeeeeeeeee. Meeeeeeeeeee, eeee eeeeeeeeeeee eee eeeeeeeeee eeeeee.

Meeeeeee-eeeee eeeeeeeeeeee eeee eeee eeeeeee ee eee eeeeeeeee eeeeeeee. Mee eeeee eeeeeeee eeeeeeeeeeee ee eee eeeeeeeee 8,8,8-eeee ee eee eeeeeeeeeeeeeeeeee eeeeeeeeeeeeeee eeeeeee eeeeeeee, eeeeee eeeeeeee-eeeee 88 ee e eeeeeeee eeeee (Meeeee 88).[‌88‌] Meee eeeeeee ee eeeeeeeeeee ee eeee eee eeeeeeeee ee e eeeee-eeeeeeee eeee ee eeee e eeeeeee ee e eeeeeeeeeeee eeeeeeeeeee eeee eeee, eee ee eeee eee eeeeeee 88 eeeee ee eeeeeeeeeee eeee eee eeee ee eeeeee eeeeeeeeeeeeeeeeee M (e.e., 88) ee eeeeeeeeeeeeeeeeee M ee eee eeeeeee eeeee.

Meeeee 88 Meeeeeee eeeeee Meeeeeeeeeeeeeeeee M[‌88‌]

Meee eeeee eeeeeeeeeeeeee eeeeeee eeeeeeeeeee eee eeee eeeeeeee ee ee eeeeeee eeeeeee, eeee e eeee eeeeee eee eeeeeeeeeee ee eeeeeeeeee- eee eeeeeeeeee-eeee eeeeeeeeee (Meeeee 88).[‌88‌] Meeeee eeeeeeee-eeeee-eeeee 88, eeeeeeee ee eeeeeeee eeeeeeeeeee eeeeeeeeee eeeeeee eee 8,8,8-eeeeeeeeeee 88 ee eeeeeeeee eeeee; eeeeeee eeeeeeeee eeeeeeeeeeeee, eeeeeeeee e Meeeeee–Meeeee eeee-eeeeeeeeeeee eeeeeeeee ee eeeeeeeee eee eeeeeeeeee eeee eeeee, eeeeeeee eeee eeeeeee ee eeeeeeeeeeeeeeeeeeeee (88).

Meeeee 88 Meeeeeeee ee Meeeeeeeeeeeeeeeeeeee[‌88‌]

Mee Meeeeee eeeee eeeeeeee e eeee eeeeeee, eeeeeee eeeeeee ee e eeeeeeee-eee-eee eeeeeeeeeee eeee eeeeeeeeeee eeeeeeee eee eeeeee eeeeeeeee (Meeeee 88).[‌88‌] Me eeee eeeee eeee eeee eeee eeeee, eeee eeeeeeee ee eeeeeee 8-eee-eee eeeeeeeeeee ee eee eeeeeeeeeee eeeeeeeee eeeeee eee eeeeeeee-eee-eee eeeeeeeee 88. Meeeeee 8-eee-eeee eeeeeeeeeee eeee eee eeeeeee eeeeee, eee eeee β-eeeeeee eeeeeeeeeee, eeeeeeee e eeeeee eeee eeeeeeeee 8π-eeeeeeeeeeeeeeeeee ee eeeeeee eeeeeee 88. Meeeeee, eee eeeeeeeeeeeeeee ee eee eeeee eeeeee eeeeeeeeeeeee eeeeeee eeeeeeeee ee eee eeeeee eee eeeeeeeeeeeeeee ee eee eeeeeeeeeee ee eee eeeeee eeeeeeee, eee eeeeeeeee eeeee ee e eeeeee ee eee- (e.e., 88) ee eeeee-eeeeeee ee eee eeeeeee. Meee eee eeee eeee ee 88 eeeeeeeeeee ee ee eeeeeeeee, eeeeeeeeee 8π-eeeeeeeeeeeee eeee eeeeeee ee eee eeeeeeee, eeeee eeeeeee e eeeeeeee eeeeeeeee eeeeeeee ee eeeeee eee eeeeee-eeee eeee 88.

Meeeee 88 Meeeeeee ee eee Meeeee Meeeeeeee[‌88‌]

Meeeeeeeeeeeee eee eeeeeeeeeeeeeeee eeeeeeeee eeeeeee e eeeeee eeeee ee eeeeeeeee eeeeeeeee-eeeeeeeee eeeeeee eeeeeeee. Meee eeeeee eee eeee eeeeeeeeeee eeeeeeee,[‌88‌‌88‌] eee eee eeee eeeeeee ee e eeeeee ee eeeeeeeee eeeeeeee. M eeeeeeeeeeee eeeeeee eeeeeee ee eeee ee e eeeeeeeee ee (+)-eeeeeeeeeeeeeeee M (88) eeeeeeee ee eee Meeee eeeee (Meeeee 88),[‌88‌] eeeee eeeeeeee eee eeeeeeeeeeeeeeeee ee eee eeee-eeeeeee eeeee, eeee eeeeeeeee ee eeeeeeeeeeeeeeee eeeeeeeee. Meee eeeeeeeee eeeeee ee eeeeeeeeee eeeeeeeee: eeeeeeeee eeeeeeeee eeeeeeee ee eee eeeeeee eeeeee, eeeeeeeeeeee ee eee eeeeeeeeeeeeeeee eeeeeee ee eee eeeeee eee eeeeeeee eeee ee eeeeeeeee 88 ee 88 eeeeeee e eee-eeeeeeeeeeeeeeee eeeeeeee (e.e., eee eeeeeeeeeeee 88).[‌88‌] Meeeeeeee eeeeeeeeeee ee eee eeeeeeeee eeeeeeeeeeeeee eeeeeee (eee eeeee) eeeee eee eeeeeeee eeeeeee eeeeeeee 88 eee 88, eeeeeeeeeeee. Meeeeee, eeee eeeeeeeeeee eeeeeeeee eeeeeee eeee eeeeeeeeeee eeeeee ee eeeeeeeeeeeeeeeeeeee.

Meeeee 88 Mee Meeee ee eee Meeeeeeee ee (+)-Meeeeeeeeeeeeeee M[‌88‌]

Me eeeeeeeeeee eeeee ee eeeeeeeeeeeeeeee eeeeeee eee eeeeeeeeeeeeeeeee eeeeeeee eeeeeeeeeeeeee eeeeeeeeeeee eeeeee eeee e eeeeeeeee(MM)-eeeeeeeee eeeeee. Meee eeeeeeeee, eeeeeeeee ee Meeeeeeeee[‌88‌] ee ee eeeeee eeeeeee eee eeeeeeee ee eeeeeee ee Meeeeeee,[‌88‌] ee eee ee eeeeeeeee eee ee eee MeeMeeeee eeeeeʼe eeeeeeeee ee eeeeeeeeeeeeee M (88) (Meeeee 88).[‌88‌] Me ee eeeeeeeee eee eeeeeeeeee-eeeeeeee eeeeeeeeeeeeee, eeeeeeeee ee eeeeeee eeeeeee 88 eeee eee(eeeeeeeeeeee)eeeeeeeeeeeeeeeee(MM) eeeee e eeeeee eeeeeeee eeeeeeeeee eee eeeeeeeee eeeeeeeeee, eeee eeeeeeee ee eeeeeee, eeeeeee eee eeeeeee eeeee 88 ee eeeeeeeee eeeee eee eeeeeeeeeeeeeeeee. Mee eeeeeeee eeeeeeee ee eeeeeee eeeeeeeeeeeeee ee eee eeeeee, eeeeeeee ee eeeeee eeeeeeee eeeeeeeee eee eeeeee eeeee eeeeeeeee. Meeee eee eeeeee eeeeee eeeeeeee eeeeeeeeee, eeee eeee eeeee 88 ee eeee eeeeeeeeee ee eeee e eeeeeee eeeeeee ee eeeee eeeeeeee;[‌88‌] eeeeeee, ee MeeMeeeeeʼe eeee, eeeeeeee ee eeeeeeeee eeee eeeeeee eeee eeee eee eeeeeeeeeeeee eeeeee 88 ee eeeeee.

Meeeee 88 Mee Meeee ee eee Meeeeeeee ee Meeeeeeeeeeeee M[‌88‌]

Meeeeeeeeeeeeeee eee eeee ee eeeeeeee eeeee eee eeee eeeeeeeee ee eeeeeeeee-eeeeeeee eeeeee eeeeeeeeee ee eeee eeeeeeeeeeeeeeee eeeeeeeeeeeee. Me eeeeeeeee eeeeeee ee eeee eeee ee eeeee ee e eeeeee eeeeeeeee ee eeeeeeeeeeeeeeee (88) ee eee eeeee ee Mee eee Me (Meeeee 88),[‌88‌] ee eeeee eeeeeeeeeeeeeeee ee eeeeee 88 eeeee ee eeeeeeeeeeeeeeee eeeeeee 88. Meee eeeeeee eeee eeeeeeeee ee eeeeeeee eeee eee eeeeeeee eeeeeee eeeee, eeeeee eeee ee eeeeeeee 88. Me eeee ee eeeee eeeeeeeee eee eeeeeeeeeee ee eeee e eeee eeeeeee ee eeeeeeeee, eee eeeeeeee eeeeeeee eeeeeee eeeeeeeeeee eeeeeee e eeeeeee eeee eeeee ee eeeeeeee ee eeeeeeeeeeeeeeee ee eeee eeeeeee eeeee.

Meeeee 88 Meeeee Meeeeeeee ee Meeeeeeeeeeeeeee[‌88‌]

Me eee eeeee eeeeeeeee, eeeeee eeeeeeee eeeeeeeee eeee ee eeeeeeeeeeeeeeee eeeeeee eeeeeeeeee ee eeeeeeeeee eeeeeeeeee-eeeeeeee eeeeeee eeee eee eeeeeeee eeeeeee. Meee ee ee eeeeeeeee eee eeeeeeeee eeee-eeeeeeeeeee eeeee ee eeeeeeeeeee eeeeeeeeee eeeee ee eeee eeeeeeeee, eee eee eeee eeee eeee eeee eeeeeeeee eee eeeee ee eeeeeeeee eeeeeee.[‌88‌,‌88‌] M eeeeeeeeeeee eeeeeeeeeee eeeeeee ee eeeee ee eee Meeeeeee eeeeeʼe eeeeeeee ee eee eeeeeeeeeeee, eee eeeeeee eeeeeeeeeee M (88), eeee eeeee ee eee MM-eeeeeeeee (Meeeee 88).[‌88‌] M eeee eeeeeee ee eeeeeeeeee eeee eeeeeeee ee eeee eeeeeeeee, eee eeee eeeeeeee ee eeeee ee eeeeeeeeeee eeee. Mee eeeeeeee eeeeeeee e eeeeeeeeeee ee eeeeeee eeeeeeeeeeeeeeeeeeeeeeeee 88 ee e eeeeeeeeeeeee–eeeeeeeeeeeeeeeee eeeeeee, eeeeeee eee eeeee ee eee eeee. Meeeeee, eee eeeeeeeee eeeeeeeeee eeeeeee 88 ee eee eee eeeee eeeeeee eeee eee eeeeeeee, ee ee eeee eeeeeeeee e [8,8]-eeeeeeeeeee eeeeeeeeeeeee ee eeee 88. Meeeeeee eeee eeeeeeeee eee eee eee eeeeeeee ee e eeeeeeeee eeeee eeeeeeeee, eee eeeeeee ee eeee eeeeeeeeeee eeeeeee ee eeeeeeeeee.

Meeeee 88 Me Meeeeeee eeeeee eee Meeeeeeeeeee[‌88‌]

M eeeee eeee ee eeeeeeeeeeeeeeee-eeeeeeeeee eeeeee eeeeeeeeeeeeee eeee eee eeee eeee ee eeeeee eeeeeeeeeeeeeee ee eeeeeee eeeeeeee ee eee eeeeeeeee ee eeeeeeeeeeee eeee eeeeeeeeeeeee eeeeeeee eeeeeeeee eee eeeeee (ee eeeeee) M—M/M—M eeee eeeeeeeee. Meee eeeeeeeee, eeeeeeeee eeeeeeeeeee ee eee Meeeeee eee Meeeee eeeeee,[‌88‌,‌88‌] ee eeeeeeee ee eee eeeeeeeee eeeee ee Meeeee 88. Me eee eeeee ee eeeee eeeeeeee, eee Meeeee eeeee eeeeee eeee eeeeeeee ee eeeeeeee 88 eeee eeeeeeee eeeee 88 eeeeeeee eeeeeee eeeeee 88.[‌88‌] Meeeeeee eeee eeeeeee- eee eeeeeeeeeeeee eeeeeeeee eee eeeeeeee ee eeee eeeeeee, ee ee eee eeeeee eeee eeeeeeeee eee eeeeeeeeeee, ee eeeeeeeee ee eee eeee eeee eee eeeeeeeeeeeeeee ee eee eeeeeee eeeeee ee eee eeeeeeeee: eeee ee eee ee eee eeeeee eeeeeeeeeeeee ee eee eeeeeee eeeeeeeeeeee 88 eeeeeeeee eee eeeee eeeeeeeee eeeeeee. Meeeee 88 ee ee eeeeeeeeeeee ee eeeee ee eeeeeeeeeeeeeeeeeeeeee M8 (88). Mee eeeeee eeeeeee, eeeeeeee ee eee Meeeeee eeeee, eeeeeee eee eeeeeeeeeee/eeeeeeee ee 8-(eeeeeeeeeeee)eeeeeee 88 eee eeeeeee eeee 88 eeeeeeeee ee eeeeeeeee(MM) eeeeeee eee 8-(eeeeeeeeeeeeeeeeeeeee)-8′,8′-eeeeeeeeeeeeeeeee (MMeee).[‌88‌] Meee eeeeeeee eeeeee eeeeeeee eee eeeeeee eeeeee eeeeeeeee, eeeeeeee ee Meeeee eeeeeeee ee eee eeeeeeeeeeee 8-eeeeeeeeeee 88; eee eeeeeee 88 eee eeeeeeee ee eee Meeee MMM eeeeee eeeeeeeee 88.

Meeeee 88 Meeeeeeee ee Meeeeeeeeeeeeeeeeeeeee M8 eee Meeee MMM Meeeee Meeeeeeee[‌88‌,‌88‌]

Meeeeeeeeeee Meeeeeeee

(8M,8eM,8M,8eM)-8-[8-(8,8-Meeeeeee-8-ee)eeeeee]-8-eeeeee-8,8,8,8,8,8e-eeeeeeeee-8e,8-eeeeeeeeeeee[8]eeeeeee-8-ee (8):[‌88‌]

Me e eeeeeeee eeee ee eeeee eeeeee 8 (888 ee, 8.88 eeee, 8 eeeee) ee MMM (88 eM) eeee eeeee Me8M (888 ee, 8.88 eeee, 88 eee%), Me8MM8 (888 ee, 8.88 eeee, 8.8 eeeee), eee Me(MMe)8 (88 ee, 8.88 eeee, 88 eee%). Mee eeeeeeeee eeeeeeeeee eee eeeeeee ee ee eee 88 eee, eee eeee eeeeee ee 88 °M ee e eeeeee eeee eee 88 e. M eeeee eeeeeeeeee eeeeeeee eeeee 88–88 eee ee 88 °M. Meeee MM eeeeeeee ee e eeeeeeee eeeeeee eeeeee eeee eee eeeeeeee eee eee eeeeeeeee ee eeeeeeeeee, eeeeeeeeee Me8M (888 ee, 8.88 eeee, 88 eee%), Me8MM8 (888 ee, 8.88 eeee, 8.8 eeeee), eee Me(MMe)8 (88 ee, 8.88 eeee, 88 eee%) eeee eeeee, eee eee eeeee eeeeeeeeee eee eeeeeee ee eee eeeeee eeee ee 88 °M eee ee eeeeeeeeee 8 e. Mee eeeeeeeeee eee eeee eeeeee ee ee eee eeeeeeee eeeeeee e eeee ee eeeeee eee (MeMMe), eee eee eeeeeeee eee eeeeeeeeeeee ee eeee eee eeeee Meee eeeeeee ee e eeeeee eee. Meee eeeeee eee eeeeeeeee ee MMM (8 eM), eee 8.8 M MMMM ee MMM (8.8 eM, 8.8 eeeee) eee eeeee. Mee eeeeeeeee eeee eee eeeeeee ee ee eee 88 e, eee eeee eeeeeeee eeee eee. ee MM8Me (88 eM). Mee eeeeeeeee eeeeeee eee eeeeeeeee eeee MM8Me8 (8 × 88 eM), eee eeeeeeee eeeeeee eeeeee eeee eeeee (Me8MM8) eee eeeeeeeeeeee, eee eee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeeee/MeMMe 8:8) ee eeeeeee eee eeeeeee ee e eeee eeeeee eee; eeeee: 888 ee (88%).

MMM8888M (8) eee MMM8888M (88) eeee Meeeeeeee 8 eee Meeeeeee 8:[‌88‌]

Me e eeee ee eeeeeeeee 8 (88.8 ee, 8.888 eeee, 8.8 eeeee) ee eee MMM (8.8 eM) ee ee eeee eeeee eeeeeeeeeeeee 8 (88.8 ee, 8.888 eeee) eee MeMe8(MMMe)8 (8.8 ee, 88.8 µeee, 88 eee%). Mee eeeeeeee eeeee eee eeeeeee ee Me eeee eee eee eeeeeee eee eeeeeee eee 88 e ee ee. Meee, eeeeeeeeee eeeeeeee (8.88 ee, 8.88 µeee, 8 eee%) eee eeeee, eee eee eeeeeee eee eeeeeee eee e eeeeeee 8 e ee ee. Me eeeeee Me8MeM, eee eeeeeee eee eeeeeee eeee MM ee Meeeee (88 ee%) eee 8 e, eee eeee eeeeeeee eeeeeee Meeeee. Mee eeeeeeeee eeee eee eeeeee eeee eee. ee MeMMM8 eee eee eeeeeee eeeee eee eeeeeeeee eeee Me8M. Mee eeeeeeee eeeeeee eeeeee eeee eeeeee eeee M8M eee eeeee, eeeee (MeMM8), eee eeeeeeeeeeee. Mee eeeee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (Me8M/eeeeee 8:8) ee eeee MMM8888M eee MMM8888M ee e eeeeee eeeee; eeeee: 88.8 ee (88%); eeeee (8/88) 8:8 (8M MMM).

MMM8888M (8) eee MMM8888M (88) eeee Meeeeeeee 88 eee Meeeeeee 88:[‌88‌]

Me e eeee ee eeeeeeeee 88 (88 ee, 8.888 eeee, 8.8 eeeee) eee eeeeeeee 88 (88 ee, 8.888 eeee, 8.8 eeeee) ee MMM (8 eM) ee ee eeee eeeee MeM (88 ee, 8.88 eeee, 8.8 eeeee), MeM (8 ee, 8.88 eeee, 88 eee%), eee Me(MMe8)8 (8 ee, 8.888 eeee, 88 eee%). Mee eeeeeee eee eeeeee ee 88 °M eee 8 e, eeee ee eee eeeeee ee ee eee eeeeeee eeee MeMMe (88 eM). Mee eeeeeee eeeee eee eeeeee eeee eee. ee MM8Me (8 × 88 eM), eee eee eeeeeeee eeeeeee eeeeee eeee eeeeeeeee eeee MeMMe (8 × 88 eM). Mee eeeeeeee eeeeeee eeeeee eeee eeeee (MeMM8) eee eeeeeeeeeeee. Meeeeeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeeee/MeMMe 8:8) eeee MMM8888M eee MMM8888M, eeeee eeeee ee eeeeeeeee ee eeeeee MMMM; eeeee: 88 ee (88%); eeeee (8/88) 8:8.

MMM8888M (8) eee MMM8888M (88) eeee Meeeeeee 88:[‌88‌]

Me eeeeeeee 88 (888 ee, 8.88 eeee, 8.8 eeeee) eeee eeeee MeMe8(MMMe)8 (88 ee, 8.888 eeee, 88 eee%) eee eeee eee MMM (88 eM). Mee eeeeeeeee eee-eeeee eeee eee eeeeee ee eee eeee ee 88 °M eee 88 e. Me eee eee ee eee eeeeeeee, e eeeeeeeeeee ee eeeeeeeee eeeee eee eeeeee eee eee eeee eee eeeeee e eeee eeeeeeeee eeeee. Mee eeeeeee eee eeeeee ee ee eee eeee eeeeeeeeeeee; eee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeeeee/MeMMe 8:8) ee eeeeee e eeeeeee ee 8, 88, 88, eee 88 (888 ee). Mee eeeeeee eee eeeeeeeee ee eeeeeeeeeee MMM (eeeeeee/Me8M 8:8, eeeeeeee eeeeeeee) ee eeeeee e eeeeeee ee 88 eee 88 [88 ee (88%); eeeee (88/88) 8.8:8] ee e eeeeeeeee eeeee eeee, eeeeeeee ee e eeeeeee ee 8 eee 88 [88.8 ee (88%); eeeee (8/88) 8.8:8] ee e eeeeeeeee eeeee eeee.

Meeeee (8M,8M,8eM,8M,M)-8-(eeee-Meeeeeeeeeeeeeeeeee)-8,8e,8,8,8,8-eeeeeeeeee-8,8,8e,8,8,8e-eeeeeeeee-8M-8,8-eeeeeeeeeeeeeeeee[8]eeeeeeee-88-eeeeeeeeeee (88):[‌88‌]

Meee: eeee eeeeeeee eee eeeeeeeee ee eee eeeeeee ee eeeee. M eeee ee eeeeeeeeeeeee 88 (8.88 e, 8.88 eeee, 8.8 eeeee) ee eeeeeee (88 eM) (MMMMMMM: eeeeeeeeee) eee eeeee eeeeee 88 (8.88 e, 8.88 eeee, 8.8 eeeee) eeee eeeeeeee eee eeeeeeeeeeee (eeeeeee eeee eeeeeeeeeee eeee eeeee 88 °M) ee eeeeeeeeeeeeee eeeeee eeeeee ee M8M, eee eeee eeeeeeeeeee ee eee MMM (88 eM). Meee eeee eee eeeee ee e eeeeeee ee Me(MMe8)8 (888 ee, 8.88 eeee, 88 eee%) eee eeeeee(M) eeeeeeeee-8-eeeeeeeeeee (888 ee, 8.88 eeee, 8.8 eeeee) ee e eeeee-eeeee Meeeeee eeeee eeeee M8, eeeeeee ee Me eeee ee eeeeee ee eeee eeeee. Mee eeeeeeeee eeeeeee eee eeeeeeeeeee eeeeee ee 88 °M (eeeeeeee eee eeee eeeeeeeeeee) eee eeeeeee eee 8 e. Meeeeeeee eeee eeeeee, eee eeeeeeeeeee eee eeeeeeeee ee 888 °M eee eee eeeeeee eee eeeeeee eee ee eeeeeeeeee 88 e. Mee eeeeeee eee eeeeee ee ee eee eeeeeee eeee eeeeee/Me8M (8:8; 88 eM); eee eeeeeeee eeeeee eee eeeeeeee eeeeeee e eeee ee eeeeee eee [eeeeee/Me8M 8:8 (8 × 888 eM)]. Mee eeeeeee eee eeeeeeeeee, eee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeee/MeMMe 88:8), eee eee eeeeeeeee eeeeeeeeee eee eeeeeee eeeeeee eeee eeeeeeee eee eeeeeeeeeeee. Me eeeeeeeeee eeeeeeeeeeee ee eeeee eeeeeeeeeeeeee eee eeeeeeeee (eeeeee/MeMMe 88:8), eeeee eeeee e eeeee eeeee eee eeeeeeee. Mee eeeee eee eeeeeeeeeeeeee (MeMM) ee eeeee eee eeeeeee ee eeeeeeeee eeeeeee; eeeee: 888 ee (88%).

Meeee (8eM,8M,8eM,88eM)-8-[8-(8,8-Meeeeeee-8-ee)eeeeee]-8-eeeeeeeee-8e,8,8e,88e-eeeeeeeeee-8M,88M-eeeeee[8′,8′:8,8]eeeeeee[8,8-e]eeeeeeee-8-eeeeeeeeeee (88):[‌88‌]

Me e eeeeeeeeee ee 88 (8.88 e, 88.88 eeee, 8.8 eeeee) eee 8-Å eeeeeeeee eeeeee (88.88 e) ee MMM (88 eM) eee eeeee eeeee 88 (8.88 e, 88.88 eeee, 8.8 eeeee), eee eee eeeeeee eee eeeeeee eee 8 e ee ee. Me eeee eeeeeeeeee eeee eeee eeeee MeMe (888 ee, 88.8 eeee, 8.8 eeeee), eee(8-eeeee)eeeeeeeee (888 ee, 8.88 eeee, 88 eee%), eee Me8(eee)8 (888 ee, 8.888 eeee, 8 eee%), eee eee eeeeeee eee eeeeeee eee 8 eee ee ee. M eeee ee eeeeeeee 88 (8.88 e, 88.88 eeee, 8.8 eeeee) ee MMM (88 eM) eee eeee eeeee ee eeee eeeeeeeeee, eee eee eeeeeee eee eeeeee ee 88 °M eee 88 eee. Mee eeeeeee eee eeeeee ee ee, M8M eee eeeee, eee eee eeeeeee eee eeeeeeeee eeee Me8M. Mee eeeeeee eeeeee eeee eeeeeeee, eeeeee eeee eeeee, eeeee (MeMM8), eee eeeeeeeeeeee ee eeee eee eeeee eeeeeee, eeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (MeMMe/eeeeee 8:88 ee 88:88) ee eeee eee eeeeeee ee e eeee eeeeee eee; eeeee: 8.88 e (88%).

Meeeeeee (M,8M,8M)-8-(Meeeeeeeeeeee)-8-eee-8-(eeeeeeeeeeeeee)-8,8,8,8,8e,88-eeeeeeeeeeeeeeeeeeeee[e,e][8]eeeeeeee-8,8(8M)-eeeeeeeeeeeee (88):[‌88‌]

Me e eeee ee eeeeeee 88 (888 ee, 8.88 eeee, 8 eeeee) ee eeeee eeeeeee (88 eM) (MMMMMMM: eeeeeeeeee) eeeee eeeee eeee eeeee eeeeeeeeeeee Me(MMe8)8 (88.8 ee, 8.888 eeee, 88 eee%) eee eeeeeeee 88 (888 ee, 8.88 eeee, 8.8 eeeee). Mee eeeeeee eee eeeeee ee eeeeee eee 88 e, eee eeee ee eee eeeeee ee ee eee eeeeeeeeeeee. Meeeeeeeeeee ee eeeee eeeeeeeeeeeeee (Me8M/eeeeee 8:8) eeeeeeee eee eeeeeee; eeeee: 88.8 ee (88%).

Meeee (8eM,8eM,88M)-88-(Meeeeeeeeeeeee)-8,8,8,8,88,88-eeeeeeeee-8M-eeeeeeeeee[8,8]eeeeeeeee[8,8-e]eeeee-8-eeeeeeeeeee (88):[‌88‌]

Me e eeeeeeee eeee ee eeeeeeeeee 88 (88 ee, 8.8888 eeee, 8 eeeee) ee eeeeeee (8 eM) eeee eeeee MeMe8(MMe8)8 (8 ee, 8.88 µeee, 88 eee%) eee MeM (8.8 ee, 8.88 µeee, 88 eee%). Mee eeeeeee eee eeeeee ee 888 °M, eee e eeeeeeee eeee ee eeeeeeee 88 (88 ee, 8.888 eeee, 8.8 eeeee) ee eeeeeee (8.8 eM) eee eeeee eee eeeeeee eeee eeee 8 e. Mee eeeeeee eee eeeeee eee e eeeeeee 8 e, eee eeee ee eee eeeeee eee eeeeeeeeeeee. Mee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeeeeee eeeee/Me8M 88:8 eeeeeeeeee 8.8% Me8M) ee eeeeee eee eeeeeee ee e eeeee eeeee; eeeee: 88.8 ee (88%).

(M)-8-Meeeee-8-{8-(8-eeeeeee-8M-eeeee-8-ee)-8-[(eeeeeeeeee-8M-eeeee-8-ee)eee]eeeeeeeeee}-8-eeeeeeeee-8,8,8,8-eeeeeeeeeeeeeeeeeee (88):[‌88‌]

Me e eeee ee 8-eeeeeee-8M-eeeeee (88; 8.88 e, 88.8 eeee, 8.8 eeeee) ee MMM (888 eM), ee −88 °M eeeee ee eeeee eeeeeeeeee, eee eeeee 8.8 M MeMe ee eeeeee (8.88 eM, 88.8 eeee, 8.8 eeeee). Mee eeeeeee eee eeeeeee eee 88 eee, eee eeee 8.8 M Me8M ee eeeeee (88.8 eM, 88.8 eeee, 8.8 eeeee) eee eeeee. Mee eeeeeee eee eeeeeee eee 88 eee ee −88 °M, eee eeee ee eee eeeeeeeee eeeeee ee ee eee eeeeeee eee 8 e. Meeee 88 (8.88 e, 8.88 eeee, 8.8 eeeee), (8-Mee)8M (888 ee, 8.88 eeee, 88 eee%), eee Me8(eee)8•MMMe8 (888 ee, 8.888 eeee, 8.8 eee%) eeee eeee eeeee ee eee eeeeeee eee ee eee eeeeeee ee ee eee 88 eee eee eeee eeeeee ee 88 °M eee 88 eee. Mee eeeeeee eee eeee eeeeee ee eee, eee 88% ee MeMM (88 eM) eee 88% ee M8M8 (88 eM) eeee eeeee. Mee eeeeeee eee eeeeeee eee 88 eee, eeee eeeeeee eeee MeMMe (888 eM), eee eeeeee eeee eeeee, eee eee eeeeeee eeeeeee eee eeeee (MeMM8) eee eeeeeeeeeeee. Mee eeeeeee eee eeeeeeeee ee MMMM (eeeeee/MeMMe 8.8:8) ee eeee eee eeeeeee; eeeee: 8.88 e (88%).

Meeeee (8M,8M,8eM,8M)-8-(eeee-Meeeeeeeeeeeeeeeeee)-8,8,8,8,8,8,8,8e-eeeeeeeee-8,8-eeeeeeeeeeeee-8-eeeeeeeeeee (88):[‌88‌]

Me e eeeeeee eeee ee Me(MMe)8 (88 ee, 8.88 eeee, 88 eee%) ee eeeeeee (88 eM) ee ee eee eeeee Me8M (88 ee, 8.88 eeee, 88 eee%). Mee eeeeeeeee eeeeeee eee eeeeeee eee 88 eee eee eeee ee eee eeeee ee e eeee ee eeeee 88 (888 ee, 8.88 eeee, 8.8 eeeee) ee eeeeeee (88 eM). Meee eeeeeee eee eeeeee ee 88 °M eee eeeeeee eee 8 e; ee eee eeee eeeeee ee 888 °M eee eeeeeee eee e eeeeeee 8 e. Mee eeeeeee eee eeee eeeeee ee ee eee eeeeeeeeeeee. Meeee eeeeeeeeeeeeee (eeeeeee/MeMMe 88:8 ee 88:8) eeeeeeee eee eeeeeee ee e eeeeeeeee eee; eeeee: 888 ee (88%); ee. 8:8 eeeeeee ee M88 eeeeeee (8M MMM).

8α,88-Meeeeeeeeeeeeeee M8 (88) eeee Meeeeeee 88 eee Meee Meeeeeeeeeeeeeeeeeeeeeeee 88:[‌88‌]

M 8.8 M ee eeee ee M8MM8 (8.8 eM) eee MeMe8(MMe8)8 (8.8888 e, 8.8888 eeee, 8 eee%) eeee eeeeeeeeeeee eeeee ee e eeee ee eeeeeeee 88 (88 ee, 8.888 eeee, 8.8 eeeee) eee eeee eeeeeeeeeeeeeeeeeeeeeeeee 88 (8.888 e, 8.888 eeee, 8.88 eeeee) ee MMM (8 eM). Mee eeeeeee eee eeeeeee eeeeeeeeee ee ee eee 8 e. Mee eeeeeee eee eeee eeeeeee eeee M8M (8 eM) eee eeeeeeeee eeee Me8M (8 × 88 eM). Mee eeeeeeee eeeeeee eeeeee eeee eeeee eee eeeeeeeeeeee; eee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (Me8M/eeeeeee 8:88) ee eeeeee eee eeeeeeeee eeeeeee, eeeee eee eeeeeeeee ee MMM (8 eM). Meee, 8 M MMMM ee MMM (8.88 eM, 8.88 eeee, 8 eeeee) eee eeeee. Mee eeeeeee eee eeeeeee eee 88 e ee ee eee eeee eeeeeee eeee eee. ee MM8Me (8 eM). Mee eeeeeee eee eeeeeeeee eeee MeMMe (8 × 88 eM). Mee eeeeeeee eeeeeee eeeeee eeee eeeee eee eeeeeeeeeeee, eee eee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (MeMMe/eeeeeee 8:8) ee eeeeee eee eeeeeee ee e eeeee eeeee (eeeeeeeeeeee eeee MMMe8/MeMMe); eeeee: 8.888 e (88%).

8α,88-Meeeeeeeeeeeeeee M8 (88) eeee Meeee 88 eee Meeeeee 88:[‌88‌]

M eeeeeee ee Me8(eee)8•MMMe8 (88 ee, 8.8888 eeee, 8 eee%) eee Me8M (88 ee, 8.888 eeee, 88 eee%) ee eeeeeee (8 eM) eee Me8M (8 eM) eee eeeeeee ee ee eee 88 eee. Meee, e eeee ee eeeeeee 88 (888 ee, 8.888 eeee, 8.8 eeeee) eee eeeee 88 (888 ee, 8.888 eeee, 8.8 eeeee) ee eeeeeee (8 eM) eee eeeee. Mee eeeeeee eee eeeeee ee eeeeee eee 8 e, eee eeee ee eee eeeeee ee ee eee eeeeeee eeee eeeeeee (8 eM). Mee eeeeeee eee eeeeeeee eeeeeee e eee ee eeeeee eee (Me8M). Meeee eeeee eeeeeeeeeeeeee (Me8M/eeeeeee 8:8) eeee e eeeeeee ee eeeeeeee (888 ee), eeeee eee eeeeeee eeee 8.8 M MMMM ee MMM (8 eM, 8.8 eeee). Mee eeeeeee eee eeeeeee ee ee eee 88 e, eee eeee eeeeeeee ee eeeee eeeeeeeeeeeeee (MeMMe) ee eeee eee eeeeeee; eeeee: 888 ee (88%).

8-(Meeeeeeeeeeeeeeeeee)-88-(eeee-eeeeeeeeeeeeeeeeeee)-8,8,8,8,8,8,8,88-eeeeeeeeeeeeeeeeeee[e]eeeeee (88):[‌88‌]

Meeeeeeeeeeee 88 (888 ee, 8.888 eeee, 8.8 eeeee) eee eeeeeeeee ee eee MeMM (8.8 eM), eee eee eeee eee eeeeeeee eeee eeeee eeeeeeee eee 88 eee. Me8M eee eeeeeeeeee eeeeeeee eeee eeeee eeeeeeee eee 88 eee. M eeee eeeeeeee eeee e eeeeeee eee eee eeeeeee eeee Me(MMe8)8 (88.8 ee, 8.8888 eeee, 88 eee%) ee e eeeeeeee, eee eeeeee eeeee eeeee. Mee eeeeeeee eeee ee eeeeeeee eeeeeeee eee eeeee ee eee eeeeeeee ee eeeeeee, eeeeeeee ee eeeeeeee Me8M (8.88 eM, 8.88 eeee, 8.8 eeeee). Mee eeeeeee eee eeeeee ee 88 °M eee 88 e eee eeee ee eee eeeeee ee ee, eee eee eeeeeee eeeeeeeee eee eeeeeee eeeee eeeeeee eeeeeeee. Meeeeeeeeeee ee eee eeeeeee ee eeeee eeeeee eeeeeeeeeeeeee [eeeeeeeee eeeee (ee 88–88 °M)/Me8M 88:8] eeeeeeee eee eeeeeee ee e eeeeeeeee eee; eeeee: 88 ee (88%).

8-Meeee-8-(eeeeeeeeeeeeee)-8,8,8,8,8,8-eeeeeeeeeeeeeeeeeee[e]eeeeee (88):[‌88‌]

Me ee eeee-eeeee eeee, eeeeeeee eeee e eeeeeee eee, eee eeeee Me(MMe8)8 (88.8 ee, 8.888 eeee, 8 eee%) ee e eeeeeeee, eee eee eeee eee eeeeee eeee e eeeeee eeeeee. Me eeee eeee eeeee e eeeeeeee (eeeee eeeeeeee, 88 eee) eeee ee eee eeeeeeeeeeeeee 88 (888 ee, 8.888 eeee, 8.8 eeeee) eee Me8M (8.88 eM, 8.88 eeee, 8.8 eeeee) ee eeeee MeMM (8.8 eM). Mee eeeeee eeeeee eee eeeeeeee eeeeeee eeee e eeeee eee, eee eee eeeeeee eee eeeeee ee 88 °M eeeee eee eeeeeeee eee eeeeeeee (MMM eeeeeeeeee; 88 e). Me eeeeeeeeee, eee eeeeeee eee eeeeee ee ee eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Meeeeeeeeeee ee eeeeee eeeeeeeeeeeeee [eeeeeeeee eeeee (ee 88–88 °M)/Me8M 8:8] eeeeeeee eee eeeeeee ee e eeeeeeeee eeeeeeeeeee eeeee; eeeee: 888 ee (88%).

Meeeee (8eM,8eM,8M,88eM)-88-Meeeeee-8,8-eeeeeeee-8,8,8e,8,8,88,88,88e-eeeeeeeeeeeeeee[8′,8′:8,8,8]eeeeeeeee[8,8-e][8,8]eeeeeee-8-eeeeeeeeeee (88):[‌88‌]

M eeee ee eeeeeeeee 88 (888 ee, 8.888 eeee), Me(MMe8)8 (88.8 ee, 8.888 eeee), eee eMe8MM (888 µM, 8.88 eeee) ee eeeeeee (8 eM) (MMMMMMM: eeeeeeeeee) eee eeeeee ee e 8-eM eeeeeeeeeeeee eeee, eeeee eee eeeeee eee eeeeeeee (eeeee eeeee) eee 8 eee. Mee eeeeeee eee eeee eeeeee ee 888 °M ee e eeeeeeeee (eeeeeeeeee eeeeeee MM eeeeeeeeeee eeeeee eeeeeeeeee) eee eeeeeeeeee ee eeee eeeeeeeeeee eee 88 eee. Mee eeeeeee eee eeeeee, eee eeeeeee eee eeeeeeeeee, eee eee eeeeeee eee eeeeeeee eeeeeeee ee eeeeee eeeeeeeeeeeeee (eeeeee eee, eeeeeee/Me8M 8:8) ee eeeeee eee eeeeeee ee e eeee eeeeee eee; eeeee: 88 ee (88%).

(+)-eeee-Meeee (M,8M,8M)-8-[(8M)-8-(Meeeeeeee)eeeeee]-8-[8-(eeeeeeeeeeeeee)eeeee]eeeeeeeeeee-8-eeeeeeeeeee (88):[‌88‌]

M eeeee-eeeee Meeeeee eeeee eee eeeeee eeeee e eeeeee ee M8 eee eeeeeee eeee Me8(eee)8 (88.8 ee, 8.88 eeee, 8 eee%), eee(8-eeeee)eeeeeeeee (88.8 ee, 8.88 eeee, 8 eee%), eee e-MeMMe (888 ee, 8.88 eeee, 8.8 eeeee). Mee eeeee eee eeeeee eeee M8, eeee e eeee ee 88 (888 ee, 8.88 eeee, 8.8 eeeee) ee eeeeeee (8.8 eM) eee eeeee eee eeeeeee, eee eee eeeeeeeee eeeeeee eee eeeeeee ee ee eee 8 eee. (M)-(8-Meeeeeeeee)eeeeeeeeeeeeeee (888 µM, 8.88 eeee, 8.8 eeeee) eee eeeee, eee eee eeeee eee eeeeee ee 888 °M eee eeeeeee eeeeeeeee. Mee eeeeeee eee eeeeee ee ee, eee eee. ee MM8Me (8 eM) eee MeMMe (8 eM) eeee eeeee. Mee eeeeeee eee eeeeeeee eeeeeee e eeee ee eeeeee eee (MeMMe, 88 eM). Mee eeeeeeee eee eeeeeeeeeee ee e eeeeeeeeee eeeeee, M8M eee eeeee (88 eM), eee eeeeee eeee eeeeeeeee, eee eee eeeeeee eeeee eee eeeeeeeee eeee MeMMe (8 × 88 eM). Mee eeeeeeee eeeeeee eeeeee eeee eeeee (Me8MM8) eee eeeeeeeeeeee. Mee eeeee eeeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee ee eeeeee eee eeeeeee ee e eeee eeeee eee; eeeee: 888 ee (88%); eeeeeee ee eeeeeeee (8M eee 88M MMM).

Meeeee 8-{(8M,8M,8M,8M)-8-Meeeeee-8-eeeeeee-8-[(M)-8-(8-eeeeeeeeeeeeeeee)eeeeee-8-ee]-8-eeeeeeeeeeeeeeee-8M-eeeee-8-ee}eeeeeee (88):[‌88‌]

MMMMMMM: Meeeee eeeeeeee ee eeeeeeeee eeeeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee eee eeeeeee eeee ee e eeee.

M 88-eM eeeee-eeeeeeee eeeee eeeeeeeeee e eeee ee eeeeeee eeee 88 (888 ee, 8.88 eeee, 8.8 eeeee) ee eeeee MeMM (8.88 eM) eee eeeeee eeee MM eee 8 eee, eee eeee eeeeee ee 8 °M eeeee 8 eee MM eeeeeeee. Meeee-8,8-eeeeeee (888 ee, 8.88 eeee, 8.8 eeeee) eee MeMe8(MMMe)8 (88.8 ee, 8.888 eeee, 8 eee%) eeee eeeee, eee eee eeee eee ee-eeeeee eeee MM eee 8 eee eee eeee eeeeeee eee ee eeeeeeeeee 8 e ee 8 °M. MeMM•M8M (88.8 ee, 8.888 eeee, 88 eee%) eee eeeee, eee eee eeee eee eeeeeee eee 88 eee ee 8 °M eee eeee eeeeee ee ee eee 88 eee. Mee eeeeeee eee eeee eeeeeee eeee MeMMe (888 eM) eee eeeeee eeee 8.8 M MeMM (888 eM). Mee eeeeeee eeeee eee eeee-eeeeeeeee eeee MeMMe (8 × 88 eM), eee eee eeeeeeee eeeeeee eeeeee eeee eeeee (Me8MM8) eee eeeeeeeeeeee. Meeeeeeeeeee ee eeeee eeeeeeeeeeeeee (MeMMe/eeeeeee 8:8) eeeeeeee eee eeeeeee ee e eeeee, eeeeeeeee eee; eeeee: 888 ee (88%).

8-(8-Meeee-8-eee-8-eeeee-8,8,8,8-eeeeeeeeee-8M-eeeeeeee-8-ee)eeeeeeee (88):[‌88‌]

Me e eee eeeee eeeeeeeeee Me(MMe)8 (88 ee, 8.888 eeee, 88 eee%), 8,8′-eeeeeeeeee (88 ee, 8.888 eeee, 88 eee%), eeeeee 88 (8.88 e, 8.88 eeee, 8.8 eeeee), eee MeMM•M8M (8.88 e, 8.88 eeee, 8.8 eeeee) eee eeeee 8,8-eeeeeee (88 eM), eee eee eeeeeeeee eeeeeee eee eeeeee ee eeeeee eee 8 e. Mee eeeeeee eee eeeeee eee eeeeeee eeee M8M (88 eM), eee eee eeeeeee eeee eee eeeeeeeee eeee MeMMe (8 × 88 eM). Mee eeeeeeee eeeeeee eeeeee eeee eeeee (Me8MM8) eee eeeeeeeeeeee. Mee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeeeeee eeeee/MeMMe 8:8 ee 8:8) ee eeee eee eeeeeee ee e eeee eeeeee eee; eeeee: 8.88 e (88%).

(8M,8M,8eM,8M,88eM)-8-[8-(eeee-Meeeeeeeeeeeeeeeeee)eeeee]-8-[(M,M)-8-eeeeeeeeee-8-eeee]-88-[(M)-eee-8-eeee]-8-(eeeeeeeeeeeeee)-8,8e,8,8-eeeeeeeeee-8M-8,88e,8-(eeee[8]eee[8,8,8]eeeee)eeeeee[8,8-e]eeeeee-8(8M)-eee (88):[‌88‌]

MMMMMMM: Meeeee eeeeeeee ee eeeeeeeee eeeeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee eee eeeeeee eeee ee e eeee.

Me e eeee ee eeeeeeeeeeeeeeeeeeeeeeeee 88 (88 ee, 8.888 eeee, 8.8 eeeee) ee eeeeeeeeeeee (8 eM) eee eeeee eMe8MMe (88 µM, 8.88 eeee, 8 eeeee). Mee eeeeeeeee eeee eee eeeee ee eeeeeee ee e Meee eeeee 8888 eeeeeeee eeeeee, eeeee ee M8 eeeeeeeeee, eeeeeee eeee Me(MMe8)8 (88 ee, 8.888 eeee, 88 eee%). Mee eeeeeeee eeeee eeeeeeee eee eeee eeeeeeee eee eee eeeeeeeee eee eeeeeee eeee MM (88 eee), eee eeeeee eeeee. Mee eeeeeeeee eee eeee eeeeeeeeeee ee 88 eee MM eee eee eeeeee ee 88 °M (eee eeee) eee 8 e, eee eeee ee 888 °M (eee eeee) eee 8.8 e. Mee eeeeeeee eeeeee eee eeeeee eee eeeeee, eee eee eeeeeee eee eeeeeeeeeeee. Mee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (Me8M/eeeeeee 8:8) ee eeee eee eeeeeee ee ee eee; eeeee: 88 ee (88%).

8-(8-Meeeeeeee-8-ee-8-ee)-8M-eeeeee (88):[‌88‌]

Me eeeeeeeeeeee 88 (888 ee, 8.88 eeee, 8.8 eeeee), Me(MMe)8 (88 ee, 8.88 eeee, 8 eee%), e-Me8M•MMM8 (888 ee, 8.88 eeee, 88 eee%), eee e-MeMMe (888 ee, 88.88 eeee, 8.8 eeeee) ee e eeeeeeee eeeeeeee eeeeee eeeee eeeee eeee eeeee 8-eeeeeeeee-8-ee-8-eeeee (88; 8.88 e, 88.88 eeee, 8 eeeee) eee eeeeeee (8.8 eM). Mee eeeeeeee eeeeee eee eeeeee eee eeeeee ee 888 °M eee 8 e, eeee eee eeeeeee eee eeeeee ee ee eee eeeeeeee eeeeeee e eeee ee Meeeee, eee eee eeeeeeee eee eeeeeeeeeeee. Mee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (Me8M/eeeeeeeee eeeee 8:88) ee eeee eee eeeeeee ee e eeeeee eee; eeeee: 888 ee (88%).

Meeeee 8-(8-Meeeeeeeeeeeeee-8-ee)-8M-eeeeee-8-eeeeeeeeeee (88):[‌88‌]

Me eeeeeeeeeeeee 88 (888 ee, 8.88 eeee), eeeeeee eeee 88 (888 ee, 8.88 eeee, 8.8 eeeee), Me(MMe)8 (8.8 ee, 8.888 eeee, 8 eee%), MMeee (88.8 ee, 8.888 eeee, 8 eee%), eee M8MM8•M8M (8.88 e, 8.88 eeee, 8.8 eeeee) eeeee eeeee eee eeeee eeeeeee (8.8 eM). Mee eeeeeeeee eeeeeee eee eeeeeee ee ee eee 8 eee, eee eeee eeeeee ee 888 °M eee 8.8 e. Mee eeeeeee eee eeeeee eee eeeeeee eeee MeMMe (88 eM) eee M8M, eee eee eeeeeee eeeee eee eeeeeeeee, eeeee (Me8MM8), eee eeeeeeeeeeee. Mee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (MeMMe/eeeeeee 8:8) ee eeeeee eee eeeeeee ee e eeeee eeeee; eeeee: 888 ee (88%).

References