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1.6.5.1.4 Concise, Enantioselective Total Synthesis of (−)-Alstonerine

DOI: 10.1055/sos-SD-219-00294

Shi, L.; Yang, Z.Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (20151608.

The macroline/sarpagine class of indole alkaloids is a rich source of biologically active natural products, some of which exhibit hypotensive, antiamoebic, and antimalarial activities.[‌71‌‌73‌] For example, alstonerine (35) has recently been reported to exhibit cytotoxic activity against two human lung cancer cell lines.[‌74‌]

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