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1.6.5.1.6 Enantioselective Synthesis of (−)-Pentalenene

DOI: 10.1055/sos-SD-219-00294

Shi, L.; Yang, Z.Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (20151610.

Triquinane natural products are considered to be classic targets for total synthesis because of their biological activity and their compact, structurally complex architectures.[‌78‌‌82‌] As the biosynthetic precursor to the pentalenolactone family of antibiotics,[‌83‌] pentalenene (47) has attracted intense and consistent interest from the synthetic community, culminating in numerous total and formal syntheses. However, most of these syntheses have produced racemic pentalenene.[‌84‌‌88‌] Therefore, an enantioselective synthesis is highly desirable.

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