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DOI: 10.1055/sos-SD-220-00002

West, J. G.; Sorensen, E. J.Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (201522.

A logical division one could imagine making in the presentation of this vast body of literature is whether the Diels–Alder reaction occurs at the beginning of the cascade or not. If the Diels–Alder is not the first step, it follows to consider three cases where it can be invoked: through the in situ generation of the diene or dienophile, or through the union of two pre-existing components promoted by earlier transformations. Each of these strategies presents certain advantages that may prove of high value in a target-oriented campaign.